In addition to memory deficits and other cognitive disturbances, patients with Alzheimer's disease (AD) experience neuropsychiatric symptoms, notably apathy, which is a state of impaired motivation observed by deficits in goal directed behavior. Apathy is a multifaceted neuropsychiatric condition and appears to be a prognostic indicator, correlating with the progression of AD. Strikingly, recent s

In the context of the massive refugee influx from Ukraine to its European neighbouring states over the last months, this update reflects on the experiences of two international exchanges led by HOUSE-IN: a JPI Urban Europe-funded project that deals with challenges at the housing-integration nexus. The exchanges revealed the impacts of this forced migration at the intersection of housing and integr

Even though membrane technology is used in numerous industrial applications, membrane fouling is still a major challenge. Valuable information on the formation kinetics and structure of the fouling layer can be obtained by in situ real-time monitoring. Quartz crystal microbalance with dissipation monitoring (QCM-D) enables the study of adsorptive fouling in situ on a model membrane. However, so fa

Passivation behavior of a N- and V-containing martensite stainless steel was studied by synchrotron-based near ambient-pressure X-ray photoelectron spectroscopy, electrochemical analyses, and thermodynamic calculation. The passive film consists of Cr3+, Fe(2, 3)+, and V(2, 3, 4)+ oxides as inner layer, and Cr3+ and Fe3+ hydroxides as outer layer. Austenitization at 1080 oC (rather than 1010 oC) an

Growing preclinical and clinical evidence highlights neurosteroid pathway imbalances in Parkinson's Disease (PD) and L-DOPA-induced dyskinesias (LIDs). We recently reported that 5α-reductase (5AR) inhibitors dampen dyskinesias in parkinsonian rats; however, unraveling which specific neurosteroid mediates this effect is critical to optimize a targeted therapy. Among the 5AR-related neurosteroids, s

Pseudozyma hubeiensis is a basidiomycete yeast that has the highly desirable traits for lignocellulose valorisation of being equally efficient at utilization of glucose and xylose, and capable of their co-utilization. The species has previously mainly been studied for its capacity to produce secreted biosurfactants in the form of mannosylerythritol lipids, but it is also an oleaginous species capa

We provide a brief overview of the educational history of Denmark and document archival and printed sources covering the development of primary, secondary, and tertiary education. In particular, we focus on student grade lists, which are available for individuals at all levels of education from the early Nineteenth century until well into the Twentieth century. We suggest that these can be used to

Most creative professionals develop and refine their talents by learning from others. In most empirical settings, estimating how this learning process fosters quality is challenging. This paper explores the transmission of quality among music composers over more than seven centuries. How does a composer’s quality influence the quality of the composers they teach? Using a unique dataset of 17,433 c

Agencies that regulate electricity providers often apply nonparametric data envelopment analysis (DEA) to assess the relative efficiency of each firm. The reliability and validity of DEA are contingent upon selecting relevant input variables. In the era of big (wide) data, the assumptions of traditional variable selection techniques are often violated due to challenges related to high-dimensional

The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases. They are downstream effectors of the Ras/ERK/MAPK signaling cascade. ERK1/2 activation directly results in the phosphorylation of RSKs, which further, through interaction with a variety of different downstream substrates, activate various signaling events. In this context, they have been shown t

Purpose: To assess the risk of recurrent venous thromboembolism (VTE) and death in patients with unreported cancer-associated incidental pulmonary embolism (iPE). Materials and methods: Matched cohort study on cancer patients with a CT study including the chest between 2014-01-01 and 2019-06-30. Studies were reviewed for unreported iPE, and cases were matched with controls without iPE. Cases and c

Many Arctic-breeding animals are at risk from local extirpation associated with habitat constriction and alterations in phenology in their Arctic environment as a result of rapid global warming.1 Migratory species face additional increasing anthropogenic pressures along their migratory routes such as habitat destruction, droughts, creation of barriers, and overexploitation.2,3 Such species can onl

Identification of protein structural neighbors to a query is fundamental in structure and function prediction. Here we present BS-align, a systematic method to retrieve backbone string neighbors from primary sequences as templates for protein modeling. The backbone conformation of a protein is represented by the backbone string, as defined in Ramachandran space. The backbone string of a query can

The β-turn is a secondary protein structure type that plays an important role in protein configuration and function. Development of accurate prediction methods to identify β-turns in protein sequences is valuable. Several methods for β-turn prediction have been developed; however, the prediction quality is still a challenge and there is infstantial room for improvement. Innovations of the proposed

Previous studies have shown that the C57 and 129 strains of mice display marked differences in behavioural performance, neuroanatomy, neurochemistry and synaptic plasticity. However, few metabolomic studies of their biofluids have been performed. As part of a series of metabolic phenotyping, the effects of gender and strain upon serum metabolite composition and variation are examined in this study

A modern diesel engine is a reliable and efficient mean of producing power. A way to reduce harmful exhaust and greenhouse gas (GHG) emissions and secure the sources of energy is to develop technology for an efficient diesel engine operation independent of fossil fuels. Renewable diesel fuels are compatible with diesel engines without any major modifications. Rapeseed oil methyl esters (RME) and o

In recent years, global technology-based competition has not only intensified, but become increasingly linked to a more comprehensive type of competition between different political and value systems. The globalist assumptions of the post-Cold War era that reliable mutually beneficial agreements could be reached with all nations, regardless of ideology, have been shattered. A previously less visib

What are the views of the Italian secondary school students about the future of education, and what conception of Europe are they developing? This report presents the results of the survey “Futures for education and europeanity”, which in 2021, in the midst of the pandemic, collected the opinions of the Italian Provincial Student Councils, representative bodies spread throughout the country, about