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A role for hormone-sensitive lipase in the selective mobilization of adipose tissue fatty acids

The mobilization of fatty acids from rat and human fat cells is selective according to molecular structure, and notably carbon atom chain length. This study aimed at examining whether the release of individual fatty acids from triacylglycerols (TAG) by hormone-sensitive lipase (HSL) plays a role in the selectivity of fatty acid mobilization. Recombinant rat and human HSL were incubated with a lipi

Cyclic syllabification in Mongolian

Mongolian is a language with a rich suffix-based morphology. Underlying forms can contain long consonant strings into which schwa vowels must be epenthesized in order to create well-formed syllables. Syllabification (including epenthesis) is governed by universal principles (the sonority law, maximality, and directionality) and a few language specific rules. Syllabification is cyclic in relation t

Final results from DELPHI on the searches for SM and MSSM neutral Higgs bosons

These final results from DELPHI searches for the Standard Model (SM) Higgs boson, together with benchmark scans of the Minimal Supersymmetric Standard Model (MSSM) neutral Higgs bosons, used data taken at centre-of-mass energies between 200 and 209 GeV with a total integrated luminosity of 224 pb(-1). The data from 192 to 202 GeV are reanalysed with improved b-tagging for MSSM final states decayin

Association of the Collagen Type 1 (COL1A 1) Sp1 Binding Site Polymorphism to Femoral Neck Bone Mineral Density and Wrist Fracture in 1044 Elderly Swedish Women.

Identification of risk factors for osteoporosis has been essential for understanding the development of osteoporosis and related fragility fractures. A polymorphism of the binding site for the transcription factor Sp1 of the collagen I alpha 1 gene (COLIA1) has shown an association to bone mass and fracture, but the findings have not been consistent, which may be related to population differences.

A CBT module with integrated simulation component for software project management education and training

Due to increasing demand for software project managers in industry, efforts are needed to develop the management-related knowledge and skills of the current and future software workforce. In particular, university education needs to provide to their computer science and software engineering (SE) students not only technology-related skills but, in addition, a basic understanding of typical phenomen

Diastolisk hjärtsvikt ­ symtom och etiologi

Symtomen vid diastolisk hjärtsvikt skiljer sig inte från dem vid systolisk funktionsnedsättning. Nya rön har framkommit om förekomsten och betydelsen av symtom och hur de bedöms av patienter och sjukvårdspersonal. Bakomliggande mekanismer till diastolisk rubbning presenteras här utifrån cellulära mekanismer och bakomliggande sjukdomar såsom hypertoni, diabetes och övervikt.

Constructing a Swedish conflict prevention policy based on a powerful idea and successful practice

The story of how conflict prevention became an integral and legitimate part of Swedish foreign policy illustrates the relationship between successful practices and powerful ideas. This article suggests that the demonstration of an idea in practice empowers the idea and contributes not only to its selection, but also to its framing and institutionalization within foreign policy. Hence, the article

Variational Problems and Level Set Methods in Computer Vision - Theory and Applications

Current state of the art suggests the use of variational formulations for solving a variety of computer vision problems. This thesis deals with such variational problems which often include the optimization of curves and surfaces. The level set method is used throughout the work, both as a tool in the theoretical analysis and for constructing practical algorithms. One frequently occurring example

The expression of hormone-sensitive lipase in clonal beta-cells and rat islets is induced by long-term exposure to high glucose

Hormone-sensitive lipase (HSL) is expressed and enzymatically active in beta-cells and has been proposed to be involved in the generation of the lipid-derived signal that seems to be necessary for glucose-stimulated insulin secretion. In this study, we investigated whether the expression of HSL in INS-1 cells and in rat islets is affected by exposure to high glucose concentrations. Incubation of I

Reduced level of serum thiols in patients with a diagnosis of active disease

Oxidative stress, or the production of oxygen-centered free radicals, has been hypothesized as the major source of DNA damage that in turn can lead to altered genetic expression, disease, and aging of humans. Serum protein thiol levels in blood are a direct measure of the in vivo reduction/oxidation (redox) status in humans, because thiols react readily with oxygen-containing free radicals to form

Physiological development of a mixed metabolic and respiratory umbilical cord blood acidemia with advancing gestational age.

Objective: To investigate respiratory and metabolic components of gestational age-dependent umbilical cord blood gas changes. Study design: Cord blood gases were determined in 1336 vigorous singletons with uncomplicated cephatic vaginal delivery at 37-43 weeks. Linear regression analysis and non-parametric statistics were used with a P < 0.05 being significant. Results: Gestational age correlated

Chemical and physical characterization of emissions from birch wood combustion in a wood stove

The purpose of this study was to characterize the emissions of a large number of chemical compounds emitted from birch wood combustion in a wood stove. Birch wood is widely used as fuel in Swedish household appliances. The fuel load was held constant during six experiments. Particles < 2.5 mum diameter were collected and the size distribution of the particles was measured. The results were compare

Parameters influencing volume and activity quantitation in SPECT

Several factors influence the accuracy to which information on the in vivo activity concentration can be obtained from SPECT images. The accuracy in image contrast and the quantitation of volume and activity has here been examined for a SPECT system aimed for absorbed dose determinations in systemic radiation therapy. The influence of source dimensions, object contrast, noise level, energy window

Cholecystokinin-A and cholecystokinin-B/gastrin receptor mRNA expression in the gastrointestinal tract and pancreas of the rat and man. A polymerase chain reaction study

BACKGROUND: Gastrin and cholecystokinin (CCK) are thought to exert trophic effects on the gastrointestinal tract and pancreas. Two types of receptors have been cloned, CCK-A and CCK-B/ gastrin. We have examined the occurrence of CCK-A and CCK-B receptor mRNA in the brain, digestive tract, pancreas, and kidney of the rat and man by Northern blot and reverse transcribed polymerase chain reaction (RT

Olfactory discrimination conditioning in the moth Spodoptera littoralis.

We used a proboscis extension reflex (PER) to study the olfactory discrimination capability in the moth Spodoptera littoralis. Already after a single experience, moths were capable to discriminate a rewarded from an unrewarded odor. In the first experiment, when rewarded and unrewarded odors were substituted for each other, moths were able to undergo reversal conditioning already after two experie