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Uncertainty propagation for SPECT/CT-based renal dosimetry in (177)Lu peptide receptor radionuclide therapy.

A computer model of a patient-specific clinical (177)Lu-DOTATATE therapy dosimetry system is constructed and used for investigating the variability of renal absorbed dose and biologically effective dose (BED) estimates. As patient models, three anthropomorphic computer phantoms coupled to a pharmacokinetic model of (177)Lu-DOTATATE are used. Aspects included in the dosimetry-process model are the

Near Field Effects and Estimation of Poisson's Ratio in Impact-Echo Thickness Testing

Based on the polarization and shape of the first symmetric Lamb mode at the zero-group velocity point (S1-ZGV), a novel approach for Impact-Echo thickness testing is proposed. In this new approach all three plate parameters (thickness, velocity and Poisson's ratio) are estimated from the same wave mode (S1-ZGV). A traditional approach based on a measurement of the longitudinal-and Rayleigh wave ve

Pyridine Adsorption on Single-Layer Iron Phthalocyanine on Au(111)

The adsorption of pyridine on monolayers of well-ordered, flat-lying iron phthalocyanine molecules on Au(111) is investigated by X-ray photoelectron spectroscopy, X-ray absorption spectroscopy, and density functional theory. It is found that pyridine both coordinates to the iron site of iron phthalocyanine and binds weakly to other sites. The iron coordination causes significant changes in the ele

Integrated protein array screening and high throughput validation of 70 novel neural calmodulin binding proteins

Calmodulin is an essential regulator of intracellular processes in response to extracellular stimuli mediated by a rise in Ca(2+) ion concentration. To profile protein-protein interactions of calmodulin in human brain, we probed a high content human protein array with fluorophore-labelled calmodulin in the presence of Ca(2+). This protein array contains 37,200 redundant proteins, incorporating ove

Accidental falls, health-related quality of life and life satisfaction: A prospective study of the general elderly population.

As the physical consequences of accidental falls in the elderly are well-researched, the long-term associations between falls and quality of life and related concepts are less known. The aim of this study was to prospectively examine the long-term relations between falls and health-related quality of life (HRQoL) and life satisfaction (LS) over six years in the general elderly population. One thou

Association of lower muscle strength with self-reported knee instability in osteoarthritis of the knee: Results from the Amsterdam Osteoarthritis Cohort

Objective To determine whether muscle strength, proprioceptive accuracy, and laxity are associated with self-reported knee instability in a large cohort of knee osteoarthritis (OA) patients, and to investigate whether muscle strength may compensate for impairment in proprioceptive accuracy or laxity, in order to maintain knee stability. Methods. Data from 283 knee OA patients from the Amsterdam Os

Rotational properties of dipolar Bose-Einstein condensates confined in anisotropic harmonic potentials

We study the rotational properties of a dipolar Bose-Einstein condensate confined in a quasi-two-dimensional anisotropic trap for an arbitrary orientation of the dipoles with respect to their plane of motion. Within the mean-field approximation, we find that the lowest-energy state of the system depends strongly on the relative strength between the dipolar and the contact interactions, as well as

User-related assessment of a driver assistance system for continuous support - a field trial

A Driver Assistance System for Continuous Support continuously evaluates the status of the host vehicle as well as the surrounding traffic based on information from on-board sensors. When the system detects a hazard, it issues a warning to the driver, depending on the degree of the hazard. The effects of this system on driver behaviour and acceptance were evaluated in a field trial carried out in

The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study.

Patients treated with clopidogrel who have higher body size exhibit greater platelet reactivity than patients with lower body size. In a retrospective analysis of the FEATHER trial, we examined the relationship between platelet response to thienopyridines clopidogrel 75mg (Clop-75), prasugrel 5mg (Pras-5), and prasugrel 10mg (Pras-10) using 3 body size indices: body weight (BW), body mass index (B

Environmental modelling of visceral leishmaniasis by susceptibility-mapping using neural networks : a case study in north-western Iran

Visceral leishmaniasis (VL) is a potentially fatal vector-borne zoonotic disease, which has become an increasing public health problem in the north-western part of Iran. This work presents an environmental health modelling approach to map the potential of VL outbreaks in this part of the country. Radial basis functional link networks is used as a data-driven method for predictive mapping of VL in

Targeting of nucleotide-binding proteins by HAMLET-a conserved tumor cell death mechanism.

HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) kills tumor cells broadly suggesting that conserved survival pathways are perturbed. We now identify nucleotide-binding proteins as HAMLET binding partners, accounting for about 35% of all HAMLET targets in a protein microarray comprising 8000 human proteins. Target kinases were present in all branches of the Kinome tree, including 26 tyr

Levodopa--carbidopa intestinal gel for treatment of advanced Parkinson''s disease

Levodopa is the mainstay of Parkinson''s disease (PD) treatment, but is often eventually associated with disabling motor complications in patients with advanced PD. The inability of perorally administered levodopa to provide more physiologic continuous dopaminergic stimulation (CDS) is a leading hypothesis to explain these complications. To investigate the cumulative efficacy and safety, and re-ev

Bacterial Imprinting at Pickering Emulsion Interfaces.

The tendency of bacteria to assemble at oil-water interfaces can be utilized to create microbial recognition sites on the surface of polymer beads. In this work, two different groups of bacteria were first treated with acryloyl-functionalized chitosan and then used to stabilize an oil-in-water emulsion composed of cross-linking monomers that were dispersed in aqueous buffer. Polymerization of the

Outcomes after ABO-incompatible heart transplantation in adults: A registry study.

In the past, ABO incompatibility was considered an absolute contraindication to heart transplantation (HT) in adults. Advances in ABO-incompatible HT in pediatric patients and ABO-incompatible abdominal transplantation in adult patients have led to clinical exploration of intentional ABO-incompatible HT in adults. However, it is not well known how outcomes in ABO-incompatible adult heart transplan