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Development and In Vitro Characterization of a Gemcitabine-loaded MUC4-targeted Immunoliposome Against Pancreatic Ductal Adenocarcinoma

CONCLUSION: Successful development and characterization of a MUC4-targeted immunoliposome shows promising results for a targeted treatment and improved retention of gemcitabine for treatment of PDAC.RESULTS: Development of a MUC4-targeted immunoliposome was confirmed and characterized by immunoblots and size characterization. The MUC4-targeted immunoliposome showed a significantly higher targeting

Cancer risks and survival in patients with multiple primary melanomas : Association with family history of melanoma and germline CDKN2A mutation status

Background Worse outcomes have been noted in patients with multiple primary melanomas (MPMs) than in patients with single primary melanomas. Objective We investigated how family history of melanoma and germline CDKN2A mutation status of MPM patients affects risks of developing subsequent melanomas and other cancers and survival outcomes. Methods Comprehensive data on cancer diagnoses and deaths of

Barbara Fish and a Short History of the Neurodevelopmental Hypothesis of Schizophrenia

The neurodevelopmental hypothesis of schizophrenia has become a paradigm broadly accepted in today's research in schizophrenia and its spectrum. This article traces the historical development of the neurodevelopmental hypothesis of schizophrenia up until the time of its explicit formulation in 1987, by Weinberger and by Murray and Lewis, with a main focus on the seminal contribution of Barbara Fis

Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with polycystic ovary syndrome

Objective: Women with a prior history of polycystic ovary syndrome (PCOS) have an increased risk of endometrial cancer (EC). Aim: To investigate whether the endometrium of women with PCOS possesses gene expression changes similar to those found in EC. Design and Methods: Patients with EC, PCOS and control women unaffected by either PCOS or EC were recruited into a cross-sectional study at the Nott

A prospective study of dietary and supplemental zinc intake and risk of type 2 diabetes depending on genetic variation in SLC30A8

Background: The solute carrier family 30 member 8 gene (SLC30A8) encodes a zinc transporter in the pancreatic beta cells and the major C-allele of a missense variant (rs13266634; C/T; R325W) in SLC30A8 is associated with an increased risk of type 2 diabetes (T2D). We hypothesized that the association between zinc intake and T2D may be modified by the SLC30A8 genotype. Results: We carried out a pro

Germline mutations in BRCA1 and BRCA2 incidentally revealed in a biobank research study : experiences from re-contacting mutation carriers and relatives

Once an incidental finding (IF) is discovered in the course of genomic research, the researchers are faced with the question of whether or not that finding should be reported back to the study participant. A large number of hypothetical studies and policy documents on this issue have been published, but there are very few empirical studies to inform the bioethics debate. Within a biobank research

Enabling the return-to-work process among people with affective disorders : a multiple-case study

Background: The Individual Enabling and Support (IES) model is an adapted, supported employment program developed to meet motivational, cognitive and time-use needs of people with affective disorders. Vocational programs for this target group have been developed but more knowledge is needed about the important characteristics and perceived usefulness of the programs. The aim of this study was to i

TP53 mutations identify younger mantle cell lymphoma patients who do not benefit from intensive chemoimmunotherapy

Despite recent advances in lymphoma treatment, mantle cell lymphoma (MCL) remains incurable, and we are still unable to identify patients who will not benefit from the current standard of care. Here, we explore the prognostic value of recurrent genetic aberrations in diagnostic bone marrow (BM) specimens from 183 younger patients with MCL from the Nordic MCL2 and MCL3 trials, which represent curre

Evidence-based scientific exercise guidelines for adults with spinal cord injury : an update and a new guideline

Objectives: To describe the process and outcomes of using a new evidence base to develop scientific guidelines that specify the type and minimum dose of exercise necessary to improve fitness and cardiometabolic health in adults with spinal cord injury (SCI). Setting: International. Methods: Using Appraisal of Guidelines, Research and Evaluation (AGREE) II reporting criteria, steps included (a) det

GDPR - En utmaning eller affärsmöjlighet?

De nya reglerna ersätter personuppgiftslagen (PUL) och syftar till att ge ett starkt enhetligt skydd för enskildas personuppgifter, men också garantera en fri rörlighet för personuppgifter inom unionen. Jonas Ledendal och Stefan Larsson utvecklar hur det stärkta skyddet inte enbart bör ses som en belastning utan även en affärsmöjlighet som kan ge upphov till innovation som stärker den personliga i

Macroscopic Domains within an Oriented TQ1 Film Visualized Using 2D Polarization Imaging

Large-area self-assembly of functional conjugated polymers holds a great potential for practical applications of organic electronic devices. We obtained well-aligned films of poly[2,3-bis(3-octyloxyphenyl)quinoxaline-5,8-diyl-alt-thiophene-2,5-diyl] (TQ1) using the floating film transfer method. Thereby, a droplet of the TQ1 solution was injected on top of the surface of an immiscible liquid subst

Risk management for maintenance of district heating networks

Underground infrastructure such as buried district heating pipes are difficult to inspect. The methods available to assess the status of the district heating pipes are often both expensive and do not provide enough evidence to determine the condition of the pipelines. This paper discusses how utilities systematically can work with risk assessments and risk classification to plan the maintenance an

Bottlenecks in district heating systems and how to address them

Problems with bottlenecks in district heating networks occur when the pipes have too small dimensions to sufficiently meet customer needs. This may result in insufficient differential pressure in DH areas attached to these pipes. Bottlenecks are especially common in expanding DH networks, as previously sufficient pipe diameters may become too small when more DH consumers are connected to the DH ne

Quantification of mitochondrial DNA copy number in suspected cancer patients by a well optimized ddPCR method

Changes in mitochondrial DNA (mtDNA) content is a useful clinical biomarker for various diseases, however results are controversial as several analytical factors can affect measurement of mtDNA. MtDNA is often quantified by taking ratio between a target mitochondrial gene and a reference nuclear gene (mtDNA/nDNA) using quantitative real time PCR often on two separate experiments. It measures relat

The expression of mental states in a humanoid robot

We explore to what degree movement together with facial features in a humanoid robot, such as eyes and mouth, can be used to convey mental states. Several animation variants were iteratively tested in a series of experiments to reach a set of five expressive states that can be reliably expressed by the robot. These expressions combine biologically motivated cues such as eye movements and pupil dil