Background: The free PSA fraction in serum of patients with various prostatic disorders is essentially unreactive with the anti-proteases in blood. Recently reported data show that it is likely to consist of a mixture of proPSA, internally cleaved PSA forms, and possibly other uncharacterized forms. Currently there are no specific methods available to measure the different free PSA subfractions an

Detta examensarbete tar avstamp och inspiration från boken Stilövningar (originaltitel Exercices de style) från 1947, av den franske författaren och poeten Raymond Queneau, i vilken han återberättar en och samma historia på 99 olika sätt. Det är vare sig den, i boken, banala grundberättelsen eller den enskilda återberättelsen som är intressant, utan det är i upprepningen och relationen dem emellanThe starting point for this thesis project and the source of inspiration is the novel ’Exercises in Style’ (original title Exercises de style) written in 1947 by French poet and author Raymond Queneau, in which he retells one and the same story, carried out in 99 different literary styles. It is not in the banal template story or the single retelling of it but rather in the repetition and the rela

Background: The favorable properties of lanthanide chelates compared with conventional fluorescent probes have attracted considerable interest. A Eu3+ chelator, 4,7-bis(chlorosulfophenyl)-1,10-phenanthroline-2,9-dicarboxylic acid (BCPDA), has been synthesized previously. Methods: We here describe immunoassay, immunohistochemistry, and microarray applications of a new streptavidin-based universal p

Public involvement in health and social care research is increasingly prioritized by policy-makers and research funders. Often, the impact of the involvement is described in terms of how it has contributed to the research outcomes and how it has affected the involved members of the public. There is a dearth of studies reporting from the perspective of researchers themselves of having involved memb

Receptors, transporters, and ion channels are important targets for therapy development in neurological diseases, but their mechanistic role in pathogenesis is often poorly understood. Gene editing and in vivo imaging approaches will help to identify the molecular and functional role of these targets and the consequence of their regional dysfunction on the whole-brain level. We combine CRISPR-Cas9

Cooperative breeding allows the costs of parental care to be shared, but as groups become larger, such benefits often decline as competition increases and group cohesion breaks down. The counteracting forces of cooperation and competition are predicted to select for an optimal group size, but variation in groups is ubiquitous across cooperative breeding animals. Here, we experimentally test if gro

We describe a novel assay for detection of point mutations. The method combines the specificity and sensitivity of the polymerase chain reaction (PCR) and allele-specific oligonucleotides (ASO) with highly sensitive time- resolved fluorometry. ASO probes differing by a single base substitution and labeled with europium (Eu) chelates were hybridized in solution simultaneously with a biotinylated ol

Correlations between mean transverse momentum [pT] and anisotropic flow coefficients v2 or v3 are measured as a function of centrality in Pb–Pb and Xe–Xe collisions at sNN=5.02 TeV and 5.44 TeV, respectively, with ALICE. In addition, the recently proposed higher-order correlation between [pT], v2, and v3 is measured for the first time, which shows an anticorrelation for the presented centrality ra

This article analyses the ideas and potential contribution of dematerialisation and eco-efficiency, and an innovation framework to promote Sustainability and increasing business competitiveness. From a strategic point of view and productivity approach, initiatives to reducing the resource intensity in producing products and providing services include: dematerialisation of the economy, extending pr

In this article we define a new concept that has not previously been theorized: non-Muslim Islam. We argue that theories and methodologies within Islamic studies produce a hierarchy between Muslim and non-Muslim productions of Islam, prioritizing the first. However, this article highlights that Islam may be produced for other purposes than belief in a deity; Islam may for example be important in p

Astrophysical neutrinos are excellent probes of astroparticle physics and high-energy physics. With energies far beyond solar, supernovae, atmospheric, and accelerator neutrinos, high-energy and ultra-high-energy neutrinos probe fundamental physics from the TeV scale to the EeV scale and beyond. They are sensitive to physics both within and beyond the Standard Model through their production mechan

The brain systems of episodic memory and oculomotor control are tightly linked, suggesting a crucial role of eye movements in memory. But little is known about the neural mechanisms of memory formation across eye movements in unrestricted viewing behavior. Here, we leverage simultaneous eye tracking and EEG recording to examine episodic memory formation in free viewing. Participants memorized mult

Research on what makes people walk/cycle for tourism is significantly understudied in relation to smart app use among Asians. To bridge this gap, this work proposes and verifies an integrated research framework that includes environment and health factors, along with heavy versus non-heavy users of smart apps based on PLS-SEM and fsQCA. Public health has a positively significant impact on behavior

Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), le

This chapter is an attempt to rectify one of the main shortfalls of the constitutive approach of communication (CCO): the absence of neoliberal capitalism in its conception of both communication and organizations. Any theory of the social must at least consider the current social order at hand, which we refer to as neoliberal capitalism. Building on the theoretical premise that communication is a

Speaker localization using microphone arrays depends on accurate time delay estimation techniques. For decades, methods based on the generalized cross correlation with phase transform (GCC-PHAT) have been widely adopted for this purpose. Recently, the GCC-PHAT has also been used to provide input features to neural networks in order to remove the effects of noise and reverberation, but at the cost