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Identification of nine new susceptibility loci for endometrial cancer

Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel

Effects of APOE ε4 on neuroimaging, cerebrospinal fluid biomarkers, and cognition in prodromal Alzheimer's disease

Apolipoprotein (APOE) ε4 is a major genetic risk factor for Alzheimer's disease (AD), but its importance for the clinical and biological heterogeneity in AD is unclear, particularly at the prodromal stage. We analyzed 151 prodromal AD patients (44 APOE ε4-negative and 107 APOE ε4-positive) from the BioFINDER study. We tested cognition, 18F-flutemetamol β-amyloid (Aβ) positron emission tomography,

Factors influencing adherence to continuous positive airway pressure treatment in obstructive sleep apnea and mortality associated with treatment failure – a national registry-based cohort study

Objectives: Adherence to continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea (OSA) is crucial. Our aim was to identify protective and risk factors against the discontinuation of CPAP treatment in patients with OSA and to estimate the mortality risk in those who were non-adherent to CPAP therapy. Methods: This was a registry-based cohort study from 37 centers across

Data on saponins, xylan and cellulose yield obtained from quinoa stalks after pressurized hot water extraction

The data we present below are linked to our research paper “Integrated process for sequential extraction of saponins, xylan and cellulose from quinoa stalks (Chenopodium quinoa Willd.)” (Gil-Ramírez et al., 2018) [1]. The objective is to provide supplementary information in order to facilitate the comprehension of the central composite experimental design (rotatable 22) used in the integrated proc

Effects of acute stress provocation on cortisol levels, zonulin and inflammatory markers in low- and high-stressed men

The virtual version of the Trier Social Stress Test (V-TSST) is an effective and standardized tool for social stress induction. This study aimed to examine gut permeability and physiological and inflammatory markers of reactivity to acute psychosocial stress. Forty young men were classified as high-stressed (HIGHS) or low-stressed (LOWS) according to the Shirom-Melamed Burnout Questionnaire. Cardi

Quantum Transport in Superconductor-Semiconductor Nanowire Hybrid Devices

In this thesis, we study quantum transport properties of superconductor-semiconductor nanowire hybrid devices. We mainly focus on the quantum transport in InSb nanowire Josephson quantum dot devices, i.e. quantum dots coupled to two pieces of superconductors. In such a structure, many-body interacting phenomena occur, such as Kondo correlation, multiple Andreev reflection, and the formation of And

Effects of a pocket cavity on heat transfer and flow characteristics of the endwall with a bluff body in a gas turbine engine

A pocket cavity is generated at the connection of two parts, namely the transition part between the Low Pressure Turbine (LPT) and Outlet Guide Vane (OGV) in a gas turbine engine. This kind of pocket cavities, due to the high Reynolds number and the specific shapes, are hardly investigated in previous researches. In the present work, the effect of the pocket on the heat transfer of the endwall wit

CEST, ASL, and magnetization transfer contrast : How similar pulse sequences detect different phenomena

Chemical exchange saturation transfer (CEST), arterial spin labeling (ASL), and magnetization transfer contrast (MTC) methods generate different contrasts for MRI. However, they share many similarities in terms of pulse sequences and mechanistic principles. They all use RF pulse preparation schemes to label the longitudinal magnetization of certain proton pools and follow the delivery and transfer

Applicability of a processes-based model and artificial neural networks to estimate the concentration of major ions in rivers

Modelling is an alternative solution to reduce the cost of water quality monitoring. Commonly, concentration of pollutants is estimated based on limited sampling information. Concentration of ions in rivers can be estimated using modelling strategies that involve statistics and artificial intelligence as well as the understanding of physical processes. Therefore, the performance of feedforward neu

Comparison between patients included in randomized controlled trials of ischemic heart disease and real-world data. A nationwide study

Background: The objective was to compare patients with ischemic heart disease (IHD) undergoing percutaneous coronary intervention (PCI) who were included in randomized controlled trials (RCTs) (trial participants) with patients who were not included (nonparticipants) on a trial-by-trial basis and according to indication for PCI. Methods: In this cohort study, we compared patients with IHD who were

Glacial geomorphological mapping : A review of approaches and frameworks for best practice

Geomorphological mapping is a well-established method for examining earth surface processes and landscape evolution in a range of environmental contexts. In glacial research, it provides crucial data for a wide range of process-oriented studies and palaeoglaciological reconstructions; in the latter case providing an essential geomorphological framework for establishing glacial chronologies. In rec

The ‘Survivorship Passport’ for childhood cancer survivors

Background: Currently, there are between 300,000 and 500,000 childhood cancer survivors (CCSs) in Europe. A significant proportion is at high risk, and at least 60% of them develop adverse health-related outcomes that can appear several years after treatment completion. Many survivors are unaware of their personal risk, and there seems to be a general lack of information among healthcare providers

Capability assessments - How to make them useful for decision-making

Capability assessments are becoming increasingly common as part of risk management activities worldwide. Despite this, there is no consensus concerning how these assessments are best conducted and presented. Recent studies suggest that two factors may influence the usefulness of capability assessments for decision-making: namely, whether the assessment includes descriptions of the resources availa