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Monoglyceride lipase (MGL) hydrolyzes monoacylglycerols (MG) to glycerol and one fatty acid. Among the various MG species, MGL also degrades 2-arachidonoylglycerol, the most abundant endocannabinoid and potent activator of the cannabinoid receptors 1 and 2. We investigated the consequences of MGL deficiency on platelet function using systemic (Mgl-/-) and platelet-specific Mgl-deficient (platMgl-/
Much has been written about the risks posed by artificial intelligence (AI). This article is interested not only in what is known about these risks, but what remains unknown and how that unknowing is and should be approached. By reviewing and expanding on the scientific literature, it explores how social knowledge contributes to the understanding of AI and its regulatory challenges. The analysis i
In recent years, the global environmental science-policy interface has come to include a greater variety of knowledge. Social scientists have joined natural scientists at the policy table, and Indigenous and local knowledge is being taken ever more seriously. But this pluralisation raises political, normative, and epistemic challenges for environmental expert organisations, including with respect
Emerging evidence suggests differential effects of therapeutic antibiotics on infant T cell responses to pathogens. In this study, we explored the impact of the treatment of mouse infants with amoxicillin and the human milk-derived antimicrobial HAMLET (human alpha-lactalbumin made lethal to tumor cells) on T cell responses to Streptococcus pneumoniae. Lung cells and splenocytes were isolated fro
The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for the pancreas, but also for the brain. In the latter, IAPP is often found in vessels, where it is highly toxic for pericytes, mural cells that have contractile properties and regulate capillary
The value-belief-norm (VBN) theory has been widely used to describe pro-sustainability behavior. Despite being used to examine issues of sustainable and public transport behavior, research using the VBN has largely overlooked the pro-environmental behavior of cyclists and walkers, which is extremely significant given the role of active transport in environmental and human health. Therefore, this s
The perception of breathlessness is mechanistically linked to the awareness of increased inspiratory neural drive (IND). Stimulation of upper airway cold receptors on the trigeminal nerve (TGN) with TGN agonists such as menthol or cool air to the face/nose has been hypothesized to reduce breathlessness by decreasing IND. The aim of this systematic scoping review was to identify and summarize the r
A prerequisite for the design and evaluation of wireless systems is the understanding of propagation channels. While abundant propagation knowledge exists for bands below 6 GHz, the same is not true for millimeter-wave frequencies. In this paper, we present the design, implementation and measurement-based verification of a re-configurable 27.5-29.5 GHz channel sounder. Based on the switched array
Nonintrusive temperature measurement is crucial in combustion research. Here, we propose a thermometric technique based on femtosecond two-photon laser-induced fluorescence of carbon monoxide (CO-fs-TPLIF). A femtosecond laser with a wavelength of 230 nm was used as an excitation source. Owing to its intrinsic broad bandwidth, dual vibrational bands of the B1Σ+ ← X1Σ+ transition of CO can be simul
This short response does two things. First, it argues that urban benchmarks have specific and structural limits not identified in the principal essay in this intervention, which curtail the kinds of constructive and critical work such benchmarks might be expected to perform. ISO 37120 is discussed as an example. Second, it proposes a pluralistic approach to engagement and offers six suggestions fo
In this work, we study the formal connections between the non-linear Fokker-Planck Equation associated with the non-additive entropy and the Boltzmann Equation with the non-additive correlation functional. The collisional term following the q-algebra is adopted. In the derivation of the non-additive Fokker-Planck Equation, two constraints are imposed on the final result: i) that the entropic index
What role should social science play in the work for transforming society towards sustainability? The background for this question is that despite massive investments in environmental research and the accumulation of data on the human impact on the environment, action remains insufficient. The severity of the current situation has led to the conclusion that moderate change is not enough; there is
Organic colloids are an important part of dissolved organic matter (DOM) yet many of their properties remain elusive. The main aims of this study were to assess how the colloidal properties of DOM extracted with water from an organic boreal soil horizon varied with the extraction protocol, and thereby provide insight into the nature of the DOM colloids and develop a mechanistic understanding of ho
Stakeholder involvement in wildlife management is important and requires knowledge about factors motivating such participation. With several goose populations increasing in Europe and goose management incorporating multiple objectives, involvement of stakeholder groups with diverse interests is needed. In this study, we examined how evaluations of geese (attitude and acceptance capacity), but also
We analyze the determinants of firm-based inventors’ collaborations with universities abroad, comparing them with collaborations with national universities. We propose a micro-founded theoretical framework that introduces the role of personal linkages and global organizational pipelines as drivers of international academic collaborations, and we empirically investigate collaborations with national
Acer campestre L. is a rarely silviculturally managed and poorly investigated European tree species which forms seminatural populations and can thus be considered as a model tree for studying post glacial colonisation and phylogeography. Herein, we studied the genetic structure of Acer campestre L. in order to investigate population and genetic diversity clines over the distribution range and for
Aims: To develop and validate sex-specific risk prediction models based on easily obtainable clinical data for predicting 5-year risk of type 2 diabetes (T2D) among individuals with impaired fasting glucose (IFG), and generate practical tools for public use. Methods: The data used for model training and internal validation came from a large prospective cohort (N = 18,384). Two independent cohorts
