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Background and ObjectiveExperimental studies suggest that the balance between short and long β-amyloid (Aβ) species might modulate the toxic effects of Aβ in Alzheimer disease (AD), but clinical evidence is lacking. We studied whether Aβ38 levels in CSF relate to risk of AD dementia and cognitive decline.MethodsCSF Aβ38 levels were measured in 656 individuals across 2 clinical cohorts: the Swedish
The process to elaborate a legally binding instrument on Business and Human Rights started in 2014. The stated ambition animating UN process is to deliver a broad-spectrum treaty that significantly increases remediation for victims. However the treaty has polarized opinion from the very beginning. To come closer to genuine points of disagreement and possible paths forward, this chapter explains an
Cerebellar dysfunction after traumatic brain injury (TBI) is commonly suspected based on clinical symptoms, although cerebellar pathology has rarely been investigated. To address the hypothesis that the cerebellar axon-myelin unit is altered by diffuse TBI, we used the central fluid percussion injury (cFPI) model in adult mice to create widespread axonal injury by delivering the impact to the fore
The compendium is an aid for lecturers to prepare classes and seminars on business and human rights in Cambodia. Teachers from several academic disciplines – law, management, political science, social science, and media – will find carefully selected materials and numerous aspects on which to build a rewarding classroom experience. The compendium has three parts. Part I covers the policy framework
Proteomics Data Collection (ProDaC) is an EU-funded Coordination Action within the 6th framework programme. It aims to simplify the publication, dissemination and utilization of proteomics data by establishing standards that will support broad data collection from the research community. As a part of ProDaC, regular workshops are organized on a half-yearly basis to enable communication and discuss
A simulation study of a new Cherenkov detector for the NA44 experiment is presented. Different positions and configurations of the counter are evaluated. The best particle identification is achieved with a CaF2 window and with the chamber placed in front of hodoscope 3 (H3).
A recent theoretical model by Andersson et al. proposes that soft gluons order themselves in the form of a helix at the end of the QCD cascades. The Authors of the model present a measure of the rapidity-azimuthal angle correlation, which they call screwiness. We searched for such a signal in DELPHI data, and found no evidence for screwiness.
Classification of expression profiles to predict disease characteristics of for example cancer is a common application in high-throughput gene and protein expression research. Cross-validation is often used to optimize design of classifiers, with the aim to construct an optimal single classifier. In this work, we explore if classification performance can be improved by aggregating classifiers into
SPECLUST is a web tool for hierarchical clustering of peptide mass spectra obtained from protease-digested proteins. Mass spectra are clustered according to the peptide masses they contain, such that mass spectra containing similar masses are clustered together. Hierarchical clustering of mass spectra with SPECLUST can in particular be useful for MS-screening of large proteomic data sets derived f
A novel approach for structure alignment is presented, where the key ingredients are: (1) An error function formulation of the problem simultaneously in terms of binary (Potts) assignment variables and real-valued atomic coordinates. (2) Minimization of the error function by an iterative method, where in each iteration a mean field method is employed for the assignment variables and exact rotation
This thesis deals with the dynamical processes in atoms and small molecules initiated by the absorption of ultrashort, coherent light pulses. The studied phenomena takeplace on the femtosecond (1 fs = 10−15 s) and attosecond (1 as = 10−18 s) timescales and critically depend on the properties of the light fields that drive them. Wework with infrared (IR) femtosecond laser pulses, which we manipulat
Background Several pressing issues face municipal planners including increased land use and climate change. Managing these issues requires a balance between different actions to accommodate citizen’s demands of ecosystem services (ES) and development projects. The implementation of ES as a new tool for assessments needs to be contrasted by research considering existing tools such as Environmental
The local lattice strain evolution during electrochemical hydrogen charging and mechanical loading in 25Cr-7Ni super duplex stainless steel were measured in-situ using synchrotron high-energy x-ray diffraction. Post-mortem electron backscattered diffraction analysis showed that the austenite phase underwent plastic deformation in the near-surface due to hydrogen-enhanced localized plasticity, wher
Climate warming has changed vegetation phenology, and the phenology-associated impacts on terrestrial water fluxes remain largely unquantified. The impacts are linked to plant adjustments and responses to climate change and can be different in different hydroclimatic regions. Based on remote sensing data and observed river runoff of hydrological station from six river basins across a hydroclimatic
Semantic segmentation is a fundamental problem in visual perception with a wide range of applications ranging from robotics to autonomous vehicles, and recent approaches based on deep learning have achieved excellent performance. However, to train such systems there is in general a need for very large datasets of annotated images. In this thesis we investigate and propose methods and setups for wh
A replacement name Obscuroplaca for the illegitimate genus Phaeoplaca is introduced. The three known species are transferred as Obscuroplaca camptidia, O. ochrolechioides, and O. tortuca.
Temporally resolved assessment of residential exposure to radon is essential for investigating radon's acute health effects. Recent studies have used large numbers of short-term radon measurements to model the spatiotemporal variations in radon concentrations. However, most short-term radon measurements in the northeastern and midwestern United States were conducted in the basements, which were le
