We performed a genome-wide association study of total hip replacements, based on variants identified through whole-genome sequencing, which included 4,657 Icelandic patients and 207,514 population controls. We discovered two rare signals that strongly associate with osteoarthritis total hip replacement: a missense variant, c.1141G>C (p.Asp369His), in the COMP gene (allelic frequency = 0.026%, P =

The groundwater contamination risk in future climates was investigated at three locations in Sweden. Solute transport penetration depths were simulated using the HYDRUS-1D model using historical data and an ensemble of climate projections including two global climate models (GCMs), three emission scenarios and one regional climate model. Most projections indicated increasing precipitation and evap

Det är hög tid att ifrågasätta flygnormen och skapa nya förutsättningar och vanor kring resande som blir bestående, skriver Sara Ullström och Kimberly Nicholas vid LUCSUS, Lunds universitets centrum för studier av uthållig samhällsutveckling.

Your body is not a point particle. The nature and direction of the forces counteracting gravity influence your experience of uniform rectilinear motion- A s does your own orientation in relation to the force of gravity. Sensors in smartphones or other devices can capture these forces, and help establish a connection between the personal experience of motion and the textbook description of forces a

Fibrosis is the result of dysregulated inflammation and tissue repair, and is characterized by the excessive accumulation of extra cellular matrix (ECM) proteins. It causes detrimental effects to the afflicted tissue and can subsequently lead to organ failure. Sterile liver inflammation and hepatic fibrosis are associated with many liver disorders of different etiologies. Both type 1 and type 2 in

Starting from the assumption that citizenship is valuable private property that would be evenmore valuable if it were transferable, the paper explores the idea of commodification of citizenship.The paper provides arguments in favor of commodification of citizenship and recommendations tohow the market for citizenship should be designed. A market for citizenships could result in animproved matching

Research on figurative meaning in Autism Spectrum Disorder (ASD) would benefit from considering a greater variety of data types and using more diverse methods. Previous studies have predominantly applied experimental methods to investigate processing of figurative language (mostly metaphor) and have for the most part concluded that individuals with ASD have deficits in figurative language comprehe

Malignant melanoma accounts for the highest number of deaths among all skin cancer types, and its incidence has increased dramatically over the past decades. Despite the tremendous therapeutic advances, treatment resistant cells emerge in the vast heterogeneity of melanoma, driving tumor relapse and poor patient outcome. The aims of the studies conducted in this thesis were to contribute to the kn

Cutaneous malignant melanoma (CMM) is one of the most aggressive skin malignancies with poor prognosisfor the patients with metastatic disease. Earlier studies have highlighted the existing molecular diversityamongst CMM tumors. Such diversity does not result from the malignant cells alone but a product of multitudeof complex interactions among the melanoma and non-melanoma cells in the tumor micr

Abstract Background: Dyspnea is a common manifestation of a range of conditions and diseases, sometimes with multiple contributing factors. A subgroup of these patients present with acute hypecapnic respiratory failure (AHRF) and are treated with non-invasive positive pressure ventilation (NPPV). Despite the biomarkers and clinical signs available to predict outcome in patients with respiratory fa

Personal data is often the target of people who are not responsible for being misused. Theft is done to benefit from people who have the data. In addition to the theft of work files, theft is also carried out on video files. Theft of this file aims to find out what the contents of the video. Someone has a private recorded video that cannot be known by others. Misuse of video files will be fatal fo