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15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells

Prostaglandin (PG) E(2) (PGE(2)) plays a predominant role in promoting colorectal carcinogenesis. The biosynthesis of PGE(2) is accomplished by conversion of the cyclooxygenase (COX) product PGH(2) by several terminal prostaglandin E synthases (PGES). Among the known PGES isoforms, microsomal PGES type 1 (mPGES-1) and type 2 (mPGES-2) were found to be overexpressed in colorectal cancer (CRC); howe

Energy-efficient terrace houses in Sweden - Simulations and measurements

Reducing energy use in buildings is essential to decrease the environmental impact. Outside Gothenburg in Sweden, 20 terrace houses were built according to the passive house standard and completed in 2001. The goal was to show that it is possible to build passive houses in a Scandinavian climate with very low energy use and to normal costs. The houses are the result of a project including research

Dose-response associations between musculoskeletal disorders and physical and psychosocial factors among construction workers

Background As musculoskeletal disorders are common in general populations and they therefore constitute a heavy burden to society, the identification of their determinants is important. The aim of this study was to identify dose-response associations for location-specific prevalences of musculoskeletal disorders with various physical exposures and psychosocial factors in a large group of workers.

Neutrophil-derived heparin binding protein-A mediator of increased vascular permeability after burns?

Increased vascular permeability and oedema formation constitute a major clinical challenge following burns. Several clinical studies show that leukocytes are systemically activated following burns. Neutrophils have the capability to increase vascular permeability via mechanisms thought to involve the release of heparin binding protein (HBP). We hypothesised that HBP is elevated in plasma after maj

A prospective study of different types of hormone replacement therapy use and the risk of subsequent breast cancer: the women's health in the Lund area (WHILA) study (Sweden)

Objectives: Reports suggest that combined estrogen plus progestin hormone replacement therapy (HRT) confers a higher breast cancer risk than estrogen alone. We aimed to establish whether breast cancer risk depends on the type of HRT formula. Methods: The cohort consisted of 6586 women, aged 50 - 64 years, from the Lund area, Sweden, with no reported breast cancer upon inclusion. We obtained inform

Isobaric Tagging-Based Quantification for Proteomic Analysis: A Comparative Study of Spared and Affected Muscles from mdx Mice at the Early Phase of Dystrophy

Duchenne muscular dystrophy (DMD) is the most common childhood myopathy, characterized by muscle loss and cardiorespiratory failure. While the genetic basis of DMD is well established, secondary mechanisms associated with dystrophic pathophysiology are not fully clarified yet. In order to obtain new insights into the molecular mechanisms of muscle dystrophy during earlier stages of the disease, we

Mechanisms underlying lipotoxicity and glucotoxicity in pancreatic islets

Although it has been known for many years that long-term exposure of pancreatic islets to a high level of free fatty acids (FFA) or glucose negatively modulates islet hormone release, the identities of signals mediating these effects are not yet fully clarified. The overall objective of this study was to investigate signal transduction pathways involved in FFA- and glucose-exerted effects on beta-

Energi, säkerhet och konflikt i ett framtidsperspektiv

Energifrågan berör många politikområden, inte minst säkerhetspolitiken. Föreställningar om framtida energisäkerhet, eller energi och säkerhet, baseras oundvikligen på underliggande antaganden och subjektiva perspektiv som gärna färgas av dagsaktuella problem. Detta kan innebära problem för dem som ägnar sig åt beslutsfattande i ett långsiktigt perspektiv. Denna rapport har ett säkerhetspolitiskt

Charge pumping in InAs nanowires by surface acoustic waves

We investigate the interaction between surface acoustic waves on a piezoelectric LiNbO3 substrate and charge carriers in InAs nanowire transistors. Interdigital transducers are used to excite electromechanical waves on the chip surface and their influence on the transport in the nanowire devices is studied at room temperature. Charge pumping is studied in different biasing conditions and in pulsed

Welfare Mix as a Contested Terrain: Political Positions on Government-Non-profit relations at national and local levels in a Social democratic Welfare State

As welfare states are increasingly challenged and replaced by welfare mix models, new ideas about the functions of non-profit and voluntary organisations NPVOs) provoke political conflicts that should be reflected in research. This paper explores the significance of political and ideological dimensions to present Changes in the Swedish welfare state regarding NPVOs as welfare services providers. I

Cardiomyocyte Cell Cycle, Renewal and Isolation

Popular Abstract in Swedish Hjärtsjukdom som orsakas av skador på hjärtmuskelceller är en av de vanligaste dödsorsakerna världen över. En framtida önskvärd behandling vore att kunna stimulera kroppens egna förmåga att återskapa hjärtmuskelceller, eller att isolera hjärtmuskelceller framställda i cellkultur. Arbete I är fokusera på studier rörande tillväxtmönstret hos hjärtmuskelceller under normaHeart disease results from the loss of cardiomyocytes following myocardial damage and is a leading cause of death worldwide. Stimulating the endogenous regeneration of cardiomyocytes or isolating them from in vitro culture is an attractive therapeutic strategy. In paper I, the focus is on the cellular growth patterns of murine cardiomyocytes under steady-state conditions. The turnover of cardiomyo

Plants as resource islands and storage units - adopting the mycocentric view of arbuscular mycorrhizal networks

The majority of herbaceous plants are connected by arbuscular mycorrhizal (AM) fungi in complex networks, but how this affects carbon (C) and phosphorus (P) allocation among symbionts is poorly understood. We utilized a monoxenic AM system where hyphae from donor roots colonized two younger receiver roots of varying C status. AM fungal C allocation from donor to receiver compartments was followed

Accelerated gradient methods and dual decomposition in distributed model predictive control

We propose a distributed optimization algorithm for mixed L_1/L_2-norm optimization based on accelerated gradient methods using dual decomposition. The algorithm achieves convergence rate O(1/k^2), where k is the iteration number, which significantly improves the convergence rates of existing duality-based distributed optimization algorithms that achieve O(1/k). The performance of the developed al