The main objectives of this study were to outline the inter-and intraindividual and overall pharmacokinetic variability of S-citalopram, S-desmethylcitalopram, and S-didesmethylcitalopram in serum by means of therapeutic drug monitoring; and to investigate potential correlations between the serum concentration and simultaneously collected clinical data. The study was conducted on outpatients in Sw

Bulgarian apico-alveolar stops and Swedish dorsovelar stops are palatalized when adjacent to front vowels. An X-ray motion film study of these assimilations (part of an ongoing investigation of the temporal organisation of coarticulation and assimilation) is presented. Two issues are examined, extrinsic vs intrinsic production of assimilation and feature spreading vs. coproduction. The articulator

This paper treats propagation of transient waves in nonstationary media, which has many applications in, for example, electromagnetics and acoustics. The underlying hyperbolic equation is a general, homogeneous, linear, first-order 2×2 system of equations. The coefficients in this system depend on one spatial coordinate and time. Furthermore, memory effects are modeled by integral kernels, which,

Background: A polymorphism in the activating component of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex, neutrophil cytosolic factor 1 (NCFI), has previously been identified as a regulator of arthritis severity in mice and rats. This discovery resulted in a search for NADPH oxidase- activating substances as a potential new approach to treat autoimmune disorders such as rh

This dissertation is based on three questions:What is orality, how has orality developed during the last 200 years in Swedish non-fiction, and what is the cause of this development? Orality is treated here as the linguistic consequence of a certain communicative function. The basis is the different conditions of speech and writing and the different styles and features that are determined by these

Popular Abstract in Swedish Artros i knäleden är en av de tio vanligaste orsakerna till smärta och funktionshinder hos vuxna. Ett av problemen med artros är att det är svårt att diagnosticera vid ett tidigt stadium. Det kan synas som förändringar på röntgen, men ofta inte förrän flera år efter att det utvecklats. Mina studier visar att det finns ett samband mellan muskelfunktion i benen och riskenThe overall purpose of this thesis was to explore the impact of exercise and functional performance on development and treatment of knee osteoarthritis in the middle aged. In this thesis, I have studied a population based cohort of middle-aged subjects (35-54 years, 42 % women) with chronic knee pain at baseline, to evaluate the longitudinal effect of muscle weakness on knee osteoarthritis develo

The present study concerns 73 patients with known unilateral breast carcinoma. Thirty of the patients had a primary invasive carcinoma removed and at a later operation contralateral subcutaneous mastectomy with implantation of a prosthesis. This was performed with or without ipsilateral breast reconstruction. Forty-three of the cases had an in situ carcinoma found by local excision, whereafter bil

The paper presents a study of the influence of the conditions applied during differential scanning calorimetry (DSC) Measurements (concentration and heating rate) oil the possible detection of the differences between gelatinization occuring in both non-irradiated and irradiated potato starch with a dose of 20kGy. Differences in gelatinization of irradiated and non-irradiated potato starch during D

Background: An increasing number of industrial robots are being programmed using CAR (Computer Aided Robotics). Sensor guidance offers a means of coping with frequent product changes in manufacturing systems. However, sensors increase the uncertainty and to preserve system robustness, a tool is needed that makes it possible to understand a sensor guided robot system before and during its actual op

The c(5 root 2 x root 2)R45 degrees-Pb/Cu(100) surface phase is investigated by means of angle resolved ultraviolet photoemission and low energy electron diffraction in the temperature range between 300 and 550 K. We identify and characterize a temperature-induced surface phase transition at 440 K from the room temperature e(5 root 2 x root 2) R45 degrees phase to a (root 2 x root 2)R45 degrees st

Well-organised PLB gives rise to a X-ray diffraction pattern overlaid by a scattering pattern arising from individual tubules within less wellorganised regions of the lattice. TEM and SAXS measurements were used to characterise the structural changes in PLB subjected to perturbation by freeze-thaw, exposure to pH 6.5, or resuspension in high-salt media. Comparison of SAXS patterns measured, before

The purpose of this study is to analyze some aspects of the relationship between R&D and economic growth. In Chapter 2 we analyze how costly imitation may be incorporated into an R&D-driven endogenous growth model. In the model, optimizing firms allocate resources to innovation or imitation. Thus, the extent of technology diffusion through imitation is endogenously determined. Costs of im

Objective. We sought to measure the bone mineral density (BMD) of various regions in the maxilla before implant treatment and to investigate correlations between these values and the BMDs of the spine and hip. Study design. Eighteen patients were examined by means of quantitative computed tomography, and the BMD of the maxillary alveolar ridge was calculated. The same patients also underwent dual-

Softwood is an interesting raw material for the production of fuel ethanol as a result of its high content of hexoses, and it has attracted attention especially in the Northern hemisphere. However, the enzymatic hydrolysis of softwood is not sufficiently efficient for the complete conversion of cellulose to glucose. Since an improvement in the glucose yield is of great importance for the overall e

Reactive oxygen intermediates are important mediators of inflammation. We investigated if hydrogen peroxide (H2O2) induces tumour necrosis factor alpha (TNFalpha) expression in cultured human cells from umbilical vein endothelium (HUVEC), aortic smooth muscle cells (SMC), peripheral blood mononuclear cells (PBMC), or the cell line Mono Mac 6. Cultures were stimulated with 200 micromol/L H2O2 for 1

The optical efficiency of concentrating solar thermal and photovoltaic systems with cylindrical geometries is asymmetrical about the optical axis. Biaxial models, based on projected incidence angles, are often used to estimate the annual performance of asymmetric concentrators. However, the use of projected angles tends to underestimate optical losses in the cover glass. In this work, a biaxial mo

This study presents practical implications for particle separation in Dissolved Air Flotation (DAF). The objectives were to localise where particles are separated from the water phase and to determine what particles, in terms of size, are removed by the DAF-process. Both pilot- and full-scale plants were investigated. Particle sizes were analysed with a light-blocking particle counter and an optic