In 2006 a genetic signal within the gene encoding transcription factor 7-like 2 (TCF7L2) was first reported to be associated with type 2 diabetes. Since then multiple genome-wide association studies have revealed this signal to be among the most strongest associations reported with this disease to date. Furthermore, multiple studies around the world have revealed the global relevance of this locus

Objective: To analyze if pre-hospital rescue times were associated with mortality in a trauma cohort arriving by ambulance to hospital in a Scandinavian urban setting. Methods: Between 2011 and 2013, individuals and pre-hospital rescue times were identified in Emergency Medical Dispatcher Centre, hospital, and forensic records in red alarm trauma. Major trauma was defined as a New InjurySeverity S

This thesis contributes to the economic literature on prosocial behavior. It includes three papers, all of which relate to the issue of policy-driven spillovers across prosocial alternatives. For example, the common fundraising practice of donation matching could affect contributions through other channels; similarly, recycling policy could affect household efforts on other environmental activitie

Energy-intensive processing industries (EPIs) such as iron and steel, aluminum, chemicals, cement, glass, and paper and pulp are responsible for a large share of global greenhouse gas emissions. To meet 2050 emission targets, a transition to low carbon, often radical innovations is required, but this process is going slow. Insights from sociotechnical and innovation systems perspectives are therefEnergy-intensive processing industries (EPIs) such as iron and steel, aluminum, chemicals, cement, glass, and paper and pulp are responsible for a large share of global greenhouse gas emissions. To meet 2050 emission targets, a transition to low carbon, often radical innovations is required, but this process is going slow. Insights from sociotechnical and innovation systems perspectives are theref

This paper presents a tool for computing thermal resistance of single U-tube ground heat exchangers placed in vertical boreholes. The tool is complete in the sense that it can compute both local and effective thermal resistances for either grouted or groundwater-filled boreholes. For grouted boreholes, it utilizes the highly accurate multipole method. For groundwater-filled boreholes, it utilizes

Purpose The purpose is to develop a framework for measuring the S&OP process performance. Design/methodology/approach The method used is a multiple case study of five companies from different industries based on data from twelve structured interviews. Findings The main result is a framework to measure the S&OP process. It includes concrete suggestions for organizations when developing me

The purpose of this study is to identify and structure challenges of measuring performance of the Sales and Operations Planning (S&OP) process. A multiple case study methodology was applied. Qualitative data was collected via 22 structured interviews with managers from six case companies in various industries. A process oriented framework was proposed by structuring the challenges based on two

Objectives. We investigated whether comorbidity burden of comatose survivors of out-of-hospital cardiac arrest (OHCA) affects outcome and if comorbidity modifies the effect of target temperature management (TTM) on final outcome. Design. The TTM trial randomized 939 patients to 24 h of TTM at either 33 or 36 °C with no difference regarding mortality and neurological outcome. This post-hoc study of

The purpose of this study was to perform an initial investigation of the possibility to determine breast cancer growth rate with 14C bomb-pulse dating. Tissues from 11 breast cancers, diagnosed in 1983, were retrieved from a regional biobank. The estimated average age of the majority of the samples overlapped the year of collection (1983) within 3σ. Thus, this first study of tumour tissue has not

Background: Previous research has revealed a clear relationship between weight gain of persons and their metabolic diseases developing later. These studies have covered only short periods lasting 4–8 years. Our goal was to collect decades’ old and often life-long anthropometric data and correlate the figures with the presence of hypertension and diabetes or both. Methods: A retrospective internat

In this paper we present a study of the interaction of Pb with a clean single-crystal Bi2CaSr2Cu2O8 superconductor surface based on photoemission and low-energy electron diffraction (LEED). Deposition of Pb on a Bi2CaSr2Cu2O8 crystal kept at room temperature gives rise to the formation of metallic Bi and oxidized Pb at the interface. This behavior could not be observed when the crystal was kept at

The formation of the Cu-Bi2CaSr2Cu2O8 interface has been studied by photoelectron spectroscopy using synchrotron radiation. Photon energies in the range 20-1000 eV were utilized in order to probe both the valence band and to monitor chemical changes upon Cu deposition, as revealed by the core-level shifts. A strong chemical reaction between Bi2CaSr2Cu2O8 and Cu is manifested by the formation of me