Search results

Immune responses against oxidized forms of LDL play a critical role in activation and regulation of the inflammatory process that characterizes all stages of atherosclerosis. In humans oxidized LDL is targeted by both IgM and IgG autoantibodies. Immunization of hypercholesterolemic animals with oxidized LDL has been shown to inhibit atherosclerosis demonstrating that at least some of these immune

In this Letter we consider the evolution of a planetary system around a star inside a wide binary. We simulate numerically the evolution of the planetary orbits for both coplanar and highly inclined systems. We find that the Kozai mechanism operates in the latter case. This produces a highly eccentric outer planet the orbit of which crosses those of some of the inner planets. Strong planet-planet

The visual content of out-of-body experiences (OBEs) has received little attention but a number of theories of OBEs include implicit predictions regarding the determinants of this phenomenological feature. Hypnagogic imagery and unusual sleep experiences, weak synaesthesia and preference for employing object and spatial visual imagic cognitive styles were psychometrically measured along with the i

Background: Legislation was passed in Sweden to stimulate the development of different housing solutions for persons suffering from severe mental illness. Among these solutions are small congregate residences built in the community to provide suitable housing and support for those not able or willing to live independently. Aims: The general aim of the present study was to compare the psychosocial

It has been argued that waterfowl and fish may threaten growth of submerged macrophytes, especially in spring during the early growth phase when plant biomass is low. A small reduction of biomass at that time might delay growth or decrease subsequent productivity. We investigated the impact of waterfowl and large fish on the spring growth of fennel pondweed (Potamogeton pectinatus L.) by employing

Antibody-based microarray is a novel technology with great promise within high-throughput proteomics. The tremendous complexity of all proteomes will, however, pose major technological challenges, especially when targeting low-abundant analytes that remains to be resolved. In this paper, we have shown that antibody microarrays readily could be used for screening of low-abundant low molecular weigh

Lumican and fibromodulin compete for collagen type I binding in vitro and fibromodulin-deficient mice have four-fold more lumican in tendons. These observations indicate that homologous sequences in lumican and fibromodulin bind to collagen type I. Here, we demonstrate that lumican binding to collagen type I is mediated mainly by Asp-213 in LRR 7. The mutation D213N in lumican impairs interaction

Individuals are often restricted to indirect cues when assessing the mate value of a potential partner. Females of some species have been shown to copy each other’s choice; in other words, the probability of a female choosing a particular male increases if he has already been chosen by other females. Recently it has been suggested that mate-choice copying could be an important aspect of human mate

Phospholipase C-gamma (PLC-gamma) isoforms are thought to be activated by both tyrosine phosphorylation and phosphatidylinositol 3,4,5 trisphosphate (PtdIns 3,4,5 P(3)), the product of phosphatidylinositol 3-kinase (PtdIns 3-kinase). In this study, we show that stimulation of mouse macrophages with either zymosan beads or bacteria (Prevotella intermedia) induced tyrosine phosphorylation of PLC-gam

The optimal definition of the size, shape and location of gross tumour volume is one of the most important steps in the planning of radiation therapy, and necessitates a proper understanding of the procedure from both the oncologic radiologist and the radiation oncologist. This overview reports on the different terms and concepts that have been recommended in the ICRU Reports for this purpose; the

Here, the problem of the classical chaos effect on dissipation in nuclear many-body systems is addressed. To investigate this problem, the energy response on parametric driving of external confinement of the simplest interacting many-body system is studied: two identical like-charged particles moving on the plane in the field of a deformed harmonic oscillator, which shows a rich structure of the c

This study evaluated the structural reliability, construct-related validity, and cultural validity generalization of the Hare Psychopathy Checklist: Screening Version (PCL:SV) in a sample of more than 560 male and female Swedish forensic psychiatric treatment patients, forensic evaluation patients, and criminal offenders. Structural reliability was excellent for most indices. PCL:SV scores were hi

Motivating people is an importnt issue for physiotherapists working with health promotion aiming at maintaining and strengthening resources for health.The aim of this literature review is to describe the theoretical foundations for how to improve work motivation and from that suggest strategies that can be used by physiotherapists in health promotion. The databases Medline and Psychlit were search

One way to assess the uncertainty in fatigue damage analysis is to use a so-called safety index. In the computation of such an index the coefficient of variation for the accumulated damage is needed. Employing the rainflow cycle count method for fatigue damage leads to, in most cases, complicated calculations. Here we present a new and simplified method to estimate the coefficient of variation for

The free energy of binding between avidin and seven biotin analogues has been calculated with the molecular mechanics Poisson- Boltzmann surface area (MM/PBSA) method. We have studied how the force field and the method to generate geometries affect the calculated binding free energies. Four different force fields were compared, but we saw no significant difference in the results. However, mixing t

During oxygen evolution, the Mn cluster in Photosystem II cycles through five oxidation states, S0-S4. S0 and S2 are paramagnetic, and can be monitored by electron paramagnetic resonance (EPR). Recently a new EPR signal from the S0 state was discovered [Åhrling et al. (1997) Biochemistry 36, 13148-13152, Messinger et al. (1997) J. Am. Chem. Soc. 119, 11349-11350]. Here, we present a well-resolved

Degradation of bovine nasal cartilage induced by interleukin-1 (IL-1) was used to study catabolic events in the tissue over 16 days. Culture medium was fractionated by two-dimensional electrophoresis (isoelectric focusing and SDS-PAGE). Identification of components by peptide mass fingerprinting revealed released fragments representing the NC4 domain of the type IX collagen {alpha}1 chain at days

The synthesis of a C-2-symmetric cleft molecule 2 based on the fused framework between bicyclo-[3.3. 1] nonane and 4-oxo-5-azaindole, incorporating a self-complementary hydrogen-bonding motif, in both racemic and enantiomerically pure forms is reported. This cleft molecule is reminiscent of analogues of Troger's base though with different cleft dimensions and tilt angles. The framework of 2 provid

The airway resistance, compliance of the respiratory system, transfer factor, and alveolar volume of 33 healthy rabbits were studied before and after exposure to diluted diesel exhaust generated in an experimental motor. Three diesel fuels and two particle traps were tested. Subsequent to the post-exposure lung function measurements, the animals were sacrificed and the lungs were processed for mor

The apparent permeability index is widely used as part of a general screening process to study drug absorption, and is routinely obtained from in vitro or ex vivo experiments. A classical example, widely used in the pharmaceutical industry, is the in vitro Caco-2 cell culture model. The index is defined as the initial flux of compound through the membrane (normalized by membrane surface area and d