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α-Synuclein (αSyn) is a neuronal protein predominantly found in the brain, whose native function seems to be associated with vesicle trafficking. While intrinsically disordered in solution, the first ca. 100 residues adopt an amphipathic α-helical structure when the protein adsorbs onto membranes. Additionally, the aggregation of αSyn into highly ordered β-sheet rich amyloid fibrils is associated
Artificially cultivated meat may have environmental benefits and harm-reductive capabilities, making it crucial to establishing ethical food production practices. However, we argue that salient factors make producing and consuming artificially cultivated meat morally problematic. We detail some of these factors and highlight their roots in different ethical traditions. These factors present seriou
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder, and ITP presents as either primary or, during the course of the disease, secondary, where approximately 20% of the cases are secondary to other diseases such as systemic autoimmune disease. The management goal of ITP is to treat or prevent severe bleeding, not to normalize the platelet count. ITP is thought to be an autoimmune syndr
In this Letter, we aim to address a knowledge gap in the intersection, and boundaries, between law(s) and circular policies, business models, and practices. By exploring the existing literature and real-life examples across the world, this work provokes further research towards a deeper understanding of the necessary changes in the legal paradigm to enable circular innovation and achieve more circ
Plate tectonics is a unique feature of Earth, but its proposed time of initiation is still controversial, with published estimates ranging from ca. 4.2 to 0.7 Ga. Paleomagnetic data can provide a robust argument for one essential aspect of plate tectonics: large-scale relative lateral motions of distinct, rigid crustal blocks. Previously, the oldest relative horizontal motion between two or more b
A new model for the estimation of the QT-RR adaptation time lag using exercise ECG stress testing has been proposed, assuming a linear heart rate trend during the test. In this work, simulated ECGs have been generated based on heart rate patterns with oscillations at different frequencies to demonstrate that the assumption can be relaxed so that the QTRR adaptation time lag can be adequately estim
Risk assessment constitutes a valuable tool for organizations responsible for critical societal functions in their effort of reducing the likelihood and mitigating the consequences of potentially harmful events. In a previous project, the researchers have contributed to the development and implementation of a method for risk assessment in the municipality of Malmö, Sweden. Shortly after the full-s
Organizations responsible for maintaining critical societal functions must be able to handle both events that can be foreseen and events that come more or less as surprises. Therefore, proactive risk management strategies that build on capacity to adapt to new and unforeseen circumstances must complement strategies that build on the ability to plan for events that can be anticipated on beforehand.
We theoretically investigate elementary excitations of dipolar quantum gases across the superfluid to supersolid phase transition in a toroidal trap. We show how decoupled first sound, second sound, and Higgs modes emerge by following their origin from superfluid modes across the transition. The structure of these excitations reveals the interplay between crystal and superfluid oscillations. Our r
SIGNIFICANCE: The irregular response to PARPi in HRD-positive and -negative tumors highlights the need for identifying additional biomarkers. This study explores the mutational landscape beyond HRD status in AOC, ultimately advancing precision oncology in future clinical practice.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) and cardiac sarcoidosis (CS) can show significant overlap in their clinical presentation. Differentiation between both is crucial for optimal patient management. Aim of this study is to develop an ECG-based machine learning model to distinguish between ARCV and CS patients. The study population included 100 patients (50 with ARCV and 50 with C
Anette Svensson och Jenny Malmqvist, författarna till ”Berätta utanför ramarna: Känslor och transmedialt berättande som litteraturdidaktisk resurs”, gör en närläsning av specialnumret Bamse: Nina i knipa som är en del i Pressbyråns lässtimulerande samarbetsprojekt. Numret består bland annat av John Ajvide Lindqvists novell ”Nina i knipa” (2018), som är en omarbetning av serien med samma namn från
I maj 2021 infördes en ny straffbestämmelse som kriminaliserar uppmaning till självmord. Bestämmelsen är brett utformad, för fällande dom krävs varken att uppmaningen lett till faktiska konsekvenser eller en konkret risk för självmord, det räcker att uppmaningen typiskt sett kunnat medföra en sådan risk. Brottet har också en oaktsamhetsvariant, som möjliggör lagföring av den som uppmanat till själ
Advances the method of isnād-cum-matn analysis for unravelling complex aspects of early Islamic history • Establishes the earliest dating of the Qurʾanic codex based on the study of hadith • Contributes to the textual history of the Qur’an • Examines the claims regarding the integrity of the text of the Qur’an • Uses case studies of the verses on stoning and breastfeeding, making it relevant to co
Increased global vegetation gross primary productivity (GPP) over the past decades has led to an enhanced terrestrial carbon sink, an important factor in mitigating global warming. However, the global spatiotemporal evolution of GPP trends is still under debate, largely limiting our understanding of the sustainability in terrestrial carbon sink. Here in this study, based on a dozen of long-term gl
