In this work we discuss a gradient plasticity formulation which relies on the introduction of higher-order gradient contributions as additional arguments of the free energy function. These gradients can be interpreted in terms of the local geometrically necessary dislocation density. This gives rise to physically well-motivated kinematic-type hardening models in contrast to purely phenomenological

The reactions between [VO(acac)2] (acac– = acetylacetonate) and the tripodal amino bisphenols 6,6′-(((2-morpholinoethyl)azanediyl)bis(methylene))bis(2,4-di-tert-butylphenol) (H2L1) and 6,6′-(((thiophen-2-ylmethyl)azanediyl)bis(methylene))bis(2,4-di-tert-butylphenol) (H2L2) as well as the tetradentate amino phenol 2,2′-((3,5-di-tert-butyl-2-hydroxybenzyl)azanediyl)bis(ethan-1-ol) (H3L3) afford the

Combining neo-institutionalism, actor network theory, and Gabriel Tarde's sociology, Czarniawska considers the key driver of organizational change to be imitation but an imitation that rests on translation. Organizations emulate one another by translating fashionable ideas according to their understanding, traditions, needs, and means. As translation in this tradition always entails a transformati

Purpose: To describe a new time-saving threshold visual field–testing strategy—Swedish Interactive Thresholding Algorithm (SITA) Faster, which is intended to replace SITA Fast—and to report on a clinical evaluation of this new strategy. Design: Description and validity analysis for modifications applied to SITA Fast. Methods: Five centers tested 1 eye of each of 126 glaucoma and glaucoma suspect p

In this work, 3-point bending tests and micro-hardness measurements were performed on pure tungsten irradiated with high-energy protons and spallation neutrons in a target of the Swiss Spallation Neutron Source (SINQ). The specimens were irradiated to doses in the range of 1.3–3.5 dpa, with 37–140 appm He, at temperatures between 75 and 110 °C. During 3-point bending tests performed at temperature

In this chapter, we discuss the open challenges in building self-aware computing systems that are still being faced by the research and development community. The challenges can be theoretical, technical, computational, or even sociological. First, we highlight the challenges associated with each of the earlier parts of the book and summarize on respective future research directions. We then offer

Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) has been clinically validated as a target for antimalarial drug discovery, as a triazolopyrimidine class inhibitor (DSM265) is currently undergoing clinical development. Here, we have identified new hydroxyazole scaffold-based PfDHODH inhibitors belonging to two different chemical series. The first series was designed by a scaffold hoppi

Cationic 1,3,5‑triaza‑phosphaadamantane (PTA) quinoline ruthenium(II) and iridium(III) complexes were successfully synthesized and characterized using standard spectroscopic and analytical techniques. The complexes were evaluated for their in vitro antiplasmodial activities against the chloroquine-sensitive (CQS) NF54 and chloroquine-resistant (CQR) K1 strains of the Plasmodium falciparum species

Devices based on molecular motor-driven cytoskeletal filaments, e.g., actin filaments, have been developed both for biosensing and biocomputational applications. Commonly, these devices require nanoscaled tracks for guidance of the actin filaments which has limited the patterning technique to electron beam lithography. Thus, large scale systems become intractable to fabricate at a high throughput

In a population-based group of women, consecutively diagnosed, with premenopausal breast cancer there was a significant correlation between tumour size and plasma prolactin (r=0.30;P

Previous studies on metabolic factors and bladder cancer (BC) risk have shown inconsistent results and have commonly not investigated associations separately by sex, smoking, and tumor invasiveness. Among 811,633 participants in six European cohorts, we investigated sex-specific associations between body mass index (BMI), mid-blood pressure (BP, [systolic + diastolic]/2), plasma glucose, triglycer

Background: The aims of this study were to establish the diagnostic accuracy of the European Cross-Cultural Neuropsychological Test Battery (CNTB) for dementia in different ethnic populations in Western Europe, to examine its ability to differentiate cognitive impairment profiles for dementia subtypes, and to assess the impact of demographic variables on diagnostic properties. Methods: The study w

Cytogenetic analysis using Giemsa banding technique was successful in 30 of the 49 adult patients with nonHodgkin lymphomas investigated. The results are correlated with previous findings in 48 non‐Hodgkin lymphoma patients studied by means of fine needle aspiration in our laboratory. As 8 patients were included in both series, the total number successfully investigated was 70. The success rate wi

Chromosome studies of a solitary plasmocytoma in the femoral bone revealed a near-haploid chromosome number of 31-32 with a loss of one homolog of each chromosome pair except #1, #7, #9, #15, #19-21, and the sex chromosomes (XY). The cytogenetic findings have been compared with 16 cases of near-haploid neoplasms from the literature studied using banding techniques. A common feature present in 13 o

Recent years have proven the benefits of electrifying the road bound vehicle fleet. With new components entering, the general understanding as well as the components as such needs to be improved. Focus in the thesis is on the design of an electric machine based on specifications of requirements for a commercial heavy vehicle such as a truck or a bus. One strict requirement is that the machine has Recent years have proven the benefits of electrifying the road bound vehicle fleet. With new components entering, the general understanding as well as the components as such needs to be improved. Focus in the thesis is on the design of an electric machine based on specifications of requirements for a commercial heavy vehicle such as a truck or a bus. One strict requirement is that the machine has

This thesis deals with ultrafast dynamics of electronic processes in rare gas atoms. The processes we explore include photoemission, where we time the emission of electrons moving away from the atomic core following ionization by a photon; and auto-ionization, where the atom spontaneously releases an electron wave-packet following photo-excitation. These processes occur on an attosecond and femtos