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Realizing that a changing society is in constant need of redefinition, the rural-urban distinction is especially important to look systematically into. One reason is that although the outdatedness of the rural-urban dichotomy is widely acknowledged, it is still largely sustained, not least in ‘rural’ and ‘urban’ development endeavors, which are often conducted separately. Such practice may seem qu
This paper aims to reflect upon the future direction of development in post-PGR (State Agricultural Farms) estates in Poland. Using the estate Chotel (gmina Izbica Kujawska, Kujawsko-Pomorskie voivodship) as a case study, we analyze the current human resources as represented by the local youth. Our point of departure is the assumption that youths, as a social category, will in the nearest future i
Seeing human geography as a nexus of temporally oscillating concepts, this paper investigates the dissemination of scientific ideas with a focus on extra-scientific factors. While scientific progress is usually evaluated in terms of intellectual achievement of the individual researcher, geographers tend to forget about the external factors that tacitly yet critically contribute to knowledge produc
This paper deals with the ways of categorising landscapes as ‘urban’ and ‘rural’ using a physicalist approach, where these terms have special meaning. The aim of this paper is to elaborate on the question whether such a division is still meaningful with regard to anthropogenic landscapes, not least in spatial planning. The concerns raised in this paper depart from the increasingly complicated stru
This paper deals with the issue of former border railway stations (FBRSs) in Poland in the context of their problematic heritage. Since the creation of those borders coincided with the development of the railway network in the 19th century, the FBRSs, now deprived of their past function, remain scattered throughout the landscape as confusing components of a troubled history in an even more confusi
Lymphocyte lineage specification and commitment requires the activation of lineage-specific genes and repression of alternative lineage genes, respectively. The mechanisms governing alternative lineage gene repression and commitment in lymphocytes are largely unknown. In this study, we demonstrate that Ezh2, which represses gene expression through methylation of histone 3 lysine 27, was essential
CONTEXT: It is important to identify patients at highest risk of fractures. OBJECTIVE: To compare the separate and combined performances of bone-related genetic risk scores (GRSs) for prediction of forearm, hip and vertebral fractures separately, as well as of trabecular and cortical bone microstructure parameters separately. DESIGN, SETTING, AND PARTICIPANTS: Using 1103 single nucleotide polymorp
I dagens samhälle med klimatförändringar och miljöproblem ses cykeln som ett allt viktigare transportmedel för att minska bilanvändning. Trafikverket konstaterade att ökad cykling medför stora vinster för samhället, inte minst för miljön. Således borde cykel prioriteras allt mer i planeringen, vilket inte alltid görs. Hur man planerar cykelinfrastruktur och vad som klassas som bra eller dålig cyke
OBJECTIVE: Reparixin is an inhibitor of CXCR1/2 chemokine receptor shown to be an effective anti-inflammatory adjuvant in a pilot clinical trial in allotransplant recipients. RESEARCH DESIGN AND METHODS: A phase 3, multicenter, randomized, double-blind, parallel-assignment study (NCT01817959) was conducted in recipients of islet allotransplants randomized (2:1) to reparixin or placebo in addition
Enterococcus faecalis cells are known to have ferric reductase activity and the ability to transfer electrons generated in metabolism to the external environment. We have isolated mutants defective in ferric reductase activity and studied their electron transfer properties to electrodes mediated by ferric ions and an osmium complex modified redox polymer (OsRP), respectively. Electron transfer med
Osteoporosis-related fractures are undertreated, due in part to misinformation about recommended approaches to patient care and discrepancies among treatment guidelines. To help bridge this gap and improve patient outcomes, the American Society for Bone and Mineral Research assembled a multistakeholder coalition to develop clinical recommendations for the optimal prevention of secondary fractuream
The outermost layer of the skin is the stratum corneum (SC), which is mainly comprised of solid proteins and lipids. Minor amounts of mobile proteins and lipids are crucial for the macroscopic properties of the SC, including softness, elasticity and barrier function. Still this minor number of mobile components are not well characterized in terms of structure or amount. Conventional quantitative d
BACKGROUND: As research in treatments for neurocognitive diseases progresses, there is an increasing need to identify cognitive decline in the earliest stages of disease for initiation of treatment in addition to determining the efficacy of treatment. For early identification, accurate cognitive tests cutoff values for cognitive impairment are essential. METHODS: We conducted a study on 297 cognit
Stimuli-responsive microgels have attracted much interest for their use as vehicles for drug delivery or as the building blocks of adaptive materials. Ionic microgel particles, including popular poly(NIPAM-co-acrylic acid), show strong mechanical responsiveness to many external stimuli, including changes in ionic strength or acidity. In this work, we demonstrate that combining multiple ionic stimu
