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Accelerating atomic-level protein simulations by flat-histogram techniques.

Flat-histogram techniques provide a powerful approach to the simulation of first-order-like phase transitions and are potentially very useful for protein studies. Here, we test this approach by implicit solvent all-atom Monte Carlo (MC) simulations of peptide aggregation, for a 7-residue fragment (GIIFNEQ) of the Cu/Zn superoxide dismutase 1 protein (SOD1). In simulations with 8 chains, we observe

Heat storage in forest biomass improves energy balance closure

Temperature measurements in trunks and branches in a mature ca. 100 years-old mixed pine and spruce forest in central Sweden were used to estimate the heat storage in the tree biomass. The estimated heat flux in the sample trees and data on biomass distributions were used to scale up to stand level biomass heat fluxes. The rate of change of sensible and latent heat storage in the air layer below t

Determination of diffusion coefficients in bovine bone by means of conductivity measurement

Measuring the diffusivity of various substances in cortical bone is in general difficult. For instance, making use of micro computed tomography requires agents that can be separated from bone, blood and other substances that exist in cortical bone. Here a more easily accessible method is presented. A series of cortical bovine bone samples were put in a saturated solution of potassium chloride for

Right-wing authoritarianism is a risk factor of torture-like abuse, but so is social dominance orientation

Right-wingauthoritarianism (RWA) is regularly implicated as a potential risk factor of abusive behavior, whereas social dominance orientation (SDO) is not. We compared RWA and the two subscales of SDO, SDO-Dominance and SDO-Egalitarianism, as factors behind legitimization and hypothetical self-involvement in the use of torture-like abusive behavior (a scenario from Abu-Ghraib military prison). Int

A taxonomy of planning and scheduling methods to support their more efficient use in construction project management

Purpose The implementation and control processes of project planning and scheduling involve a wide range of methods and tools. Despite the development and modification and integration of the project management theory with newer scheduling approaches in particular, practitioners’ views on the efficiency and effectiveness of these methods and tools differ. This situation can be attributed in part to

New seeds, gender norms and labor dynamics in Hoima District, Uganda

NERICA, a new group of high-yielding and stress-tolerant upland rice varieties developed by the Africa Rice Center, is changing production strategies of many Ugandan households. This article contributes a better understanding of processes leading to NERICA-related household outcomes in Hoima District, Uganda, by examining patterns of intrahousehold production relations and their consequences for h

Constrained Multilinear Detection and Generalized Graph Motifs

We introduce a new algebraic sieving technique to detect constrained multilinear monomials in multivariate polynomial generating functions given by an evaluation oracle. The polynomials are assumed to have coefficients from a field of characteristic two. As applications of the technique, we show an O^∗(2^k)-time polynomial space algorithm for the k-sized Graph Motif problem. We also introduce a ne

Acceleration Feedback Control for Nonlinear Teleoperation Systems with Time Delays

A procedure for acceleration feedback control of the delayed nonlinear teleoperation system is proposed. The acceleration feedback is applied to the master controller, while in the slave side the position error plus nonlinear damping controller is used to guarantee the input-to-state stability (ISS) of the controlled system. The Lyapunov-Krasovskii methodology is applied to analyse the ISS of the

Testing the Feasibility of Using the ForSAFE-VEG Model to Map the Critical Load of Nitrogen to Protect Plant Biodiversity in the Rocky Mountains Region, USA

The ForSAFE-VEG model was used to estimate atmospheric nitrogen deposition and climate effects on soil chemistry and ground vegetation in alpine and subalpine zones of the northern and central Rocky Mountains region in the USA from 1750 to 2500. Model simulations for a generalized site illustrated how the critical load of atmospheric nitrogen deposition could be estimated to protect plant biodiver

Improved glucose regulation in type 2 diabetic patients with DPP-4 inhibitors: focus on alpha and beta cell function and lipid metabolism.

Inhibition of dipeptidyl peptidase-4 (DPP-4) is an established glucose-lowering strategy for the management of type 2 diabetes mellitus. DPP-4 inhibitors reduce both fasting and postprandial plasma glucose levels, resulting in reduced HbA1c with low risk for hypoglycaemia and weight gain. They act primarily by preventing inactivation of the incretin hormones glucose-dependent insulinotropic polype

Multiple myeloma and infections: a population-based study on 9253 multiple myeloma patients.

Infections are a major cause of morbidity and mortality in patients with multiple myeloma. To estimate the risk of bacterial and viral infections in multiple myeloma patients, we used population-based data from Sweden to identify all multiple myeloma patients (n=9 253) diagnosed from 1988 to 2004 with follow-up to 2007 and 34 931 matched controls. Cox proportional hazard models were used to estima

Glucagon-like peptide 1 (GLP-1) analogue combined with insulin reduces HbA1c and weight with low risk of hypoglycemia and high treatment satisfaction

Aims: To evaluate the effects of adding glucagon-like peptide-1 (GLP-1) analogue therapy to insulin on glycated hemoglobin (HbA1c), weight, insulin dosage, treatment satisfaction, and risk of hypoglycaemia. Methods: Type 2 diabetes patients with insulin therapy receiving a GLP-1 analogue at 4 Swedish centers were studied. Hypoglycemia was evaluated using glucometers and patient self-report. The Di

The Swedish Confederation for Professional Employees (TCO) and trust-based working time

Abstract in UndeterminedThis article aims to provide a historical perspective to the emergence of trust-based control systems in the workplace. These systems are often seen as a response to increasedflexibility requirements following the progress of digital technology, globalisationand an increased knowledge content in production. In contrary to this opinion, itis argued in the article that the ph

WNT3 involvement in human bladder exstrophy and cloaca development in zebrafish.

Bladder exstrophy, a severe congenital urological malformation when a child is born with an open urinary bladder, is the most common form of bladder exstrophy-epispadias complex (BEEC) with an incidence of 1:30.000 children of Caucasian descent. Recent studies suggest that WNT genes may contribute to the etiology of bladder exstrophy. Here, we evaluated WNT pathway genes in 20 bladder exstrophy pa