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Changes in drug use in the general population during the COVID-19 pandemic and their long-term consequences are not well understood. We employed natural language processing and machine learning to analyse a large dataset of self-reported rates of and reasons for drug use during the pandemic, along with their associations with anxiety, depression and substance use problems post-pandemic. Our findin

We investigated the mRNA expression of G protein-coupled receptors (GPCRs) in cells from four human vascular beds: umbilical vein (HUVEC), microvasculature (MVEC), aorta (HAEC), and coronary artery (CAEC). Our study revealed that the orphan receptor ELTD1 (ADGRL4) was the most abundantly expressed GPCR mRNA in all four EC types. When recombinantly expressed in U87 cells, ELTD1 receptors activated

Density functional theory (DFT) thermochemistry of 3d transition-metal complexes is well-known to be sensitive to the amount of exact Hartree-Fock exchange incorporated into the exchange-correlation functional. For example, relative energies of different protonation states of iron-sulfur complexes may vary by hundreds of kJ/mol among different DFT methods. In the present study, we examine the rela

Background: Unhealthy lifestyle behaviours, including unhealthy alcohol consumption, physical inactivity, smoking, and nonadherence to dietary recommendations, are major contributors to non-communicable diseases and mortality. While adopting healthy behaviours can reduce these risks in middle-aged adults, research is limited. Therefore, the aim of this study was to assess the distribution of unhea

OBJECTIVE: We previously demonstrated that artificial intelligence (AI)-directed chest computed tomography (CT)-based total opacity scores (TOS) are associated with high-risk obstructive sleep apnea (OSA) based on the Berlin Questionnaire. In the current study, we examined the association between TOS severity and OSA severity based on polysomnography (PSG) recordings among participants with a hist

Study region: The Tibetan Plateau (TP) is a high-altitude region characterized by harsh environmental conditions and limited accessibility, making the monitoring of its numerous lakes a significant challenge. This region is crucial for hydrological studies, and its numerous lakes play an important role in regional water dynamics and climate change research. Study focus: This study evaluates the ap

There is active crosstalk between tumor cells and the tumor microenvironment during metastatic progression, a process that is significantly affected by obesity, particularly in breast cancer. Here we analyze the impact of a high fat diet (HFD) on metastasis, focusing on the role of platelets in the formation of premetastatic niches (PMNs). We find that a HFD provokes pre-activation of platelets an

Methanol is a promising renewable fuel that can be used to reduce the carbon intensity of internal combustion engines. In any combustion strategy with methanol, both unburned methanol and formaldehyde emissions are criteria pollutants that are potential drawbacks, so their accurate measurement is critical. The flame ionization detectors (FIDs) typically used in engine research to measure unburned

Japan’s rich archaeological record, supported by well-established chronological and typological frameworks, offers valuable opportunities to investigate prehistoric socio-cultural responses to climate change, although comprehensive studies remain limited. This exploratory paper examines the impact of climatic disruptions—particularly the 8.2 ka event—on Jomon foragers in Kyushu, aiming to develop

Aims: Studies have shown the association between personal history of diabetes mellitus (DM type 1/2) and risk of colorectal cancer (CRC). This study aims to find the association between the family history of diabetes and CRC risk. Methods: This large nationwide cohort study leveraged data from several Swedish nationwide registers (follow-up: 1964–2018) to compare the risk using standardized incide

Background: Gambling disorder severely impacts the affected individual's daily life and is considered to be a major public health issue. Gambling disorder may be a risk factor for suicidal behavior, but matched case-control studies are few. This study aims to explore suicidal behavior, and risk factors for it, among patients with GD in comparison with age- and gender-matched controls. Methods: Thi

Objective: Although patients prefer describing their problems using words, mental health interventions are commonly evaluated using rating scales. Fortunately, recent advances in natural language processing (i.e., AI-methods) yield new opportunities to quantify people's own mental health descriptions. Our aim was to explore whether responses to open-ended questions, quantified using AI, provide ad

In analysing five dimensional orbifolds with exceptional gauge groups, we seek to find stable vacua configurations which satisfy the minimal requirements for asymptotic grand unified models. In this respect we show that no minimal asymptotic grand unified theory can be built. Our results point towards non-minimal models based on E6: one featuring supersymmetry, and the other needing a modification

Background: Stroke and acute myocardial infarction (AMI) rank among the leading causes of mortality. Physical activity and exercise are recommended as part of rehabilitation after AMI to prevent cardiovascular events, but the importance for stroke prevention has not been investigated using population-based data. Objectives: To determine associations between participation in exercise-based cardiac

Context. The coupling between the dark matter (DM) halo and the stellar disc is a key factor in galactic evolution. While the interaction between structures like the Galactic bar and DM halos has been explored (e.g. slowing down of the bar due to dynamical friction), the effect of spiral arms on the DM halo distribution has received limited attention. Aims. We aim to detect and characterize the in

Background: Apical hypertrophic cardiomyopathy (ApHCM) is a distinct variant of hypertrophic cardiomyopathy (HCM). Few studies have focused on the genetic determinants of this subtype. We aimed to investigate the genetic basis of apical hypertrophy in a Swedish cohort. Methods–Results: Longitudinal data on 58 unrelated index patients with ApHCM from the Southeast healthcare region in Sweden from 2

Accurately characterizing dry-season water availability (Wd) is critical for projecting terrestrial carbon exchange and global water security. Wd is commonly calculated as the minimum value of precipitation minus evapotranspiration within each calendar year. However, Earth System Model (ESM) projected Wd contains substantial uncertainties and can disagree on even the sign. Based on a newly propose

In this paper, we present an experiment that shows conflicting findings from truth-value judgments and eye-tracking data for testing reference assignment of proper names. We argue that if eye-tracking is a more reliable method than truth-value judgment tasks, then our eye-tracking data provide stronger empirical support for Kripke’s causal-historical theory of reference for proper names. We also a

Two major trends on children's skills to comprehend metaphors have governed the literature on the subject: the literal stage hypothesis vs. the early birds hypothesis (Falkum, 2022). We aim to contribute to this debate by testing children's capability to comprehend novel metaphors ('X is a Y') in Spanish with a child-friendly, picture selection task, while also tracking their gaze. Further, given

This study aimed to quantify the impact of sponge city facilities on both runoff reduction and carbon emission mitigation, providing valuable insights for sustainable urban development. Using the Storm Water Management Model (SWMM) 5.2 in conjunction with carbon emission factor calculations, we comparatively evaluated the annual runoff reduction and carbon emission abatement potential of tradition