The paper considers a time-adaptive finite element method for determination of drug efficacy in a parameter identification problem (PIP) for a system of ordinary differential equations (ODE) that describes dynamics of the primary human immunodeficiency virus (HIV) infection with drug therapy. Tikhonov’s regularization method, optimization approach and finite element method to solve this problem ar

The medieval Swedish knittelvers has traditionally been analysed as consisting of end-rhymed verses of four beats, each divided into half-lines by a cæsura. While the rhymes are obvious, the four beats and the cæsura are not. Notwithstanding this uncertainty, the traditional analysis has persisted, and has recently been reinforced by Wåhlin (1989, 1999) who stresses the regularity of the four-beat

Den politiska idéhistorien har traditionellt skildrats ur ett västligt perspektiv. Platon och Aristoteles är välkända gestalter, liksom Locke och Marx. Betydligt mindre kända är däremot Chanakya, Zhu Xi, Kang Youwei och Mulla Sadra, för att ta några exempel. Denna bok vidgar perspektivet och jämför den västerländska traditionen med den politiska idéutvecklingen i andra delar av världen, främst Ind

In recent years, III-V semiconductor materials have received increasing attention due to their admirable electronic properties like direct tunable bandgaps and high charge carrier mobility. Indium Antimonide (InSb) possesses the largest electron mobility among III-V materials and is promising for infrared detectors, high-speed field effect transistors, and spintronics. Incorporation of bismuth (Bi

Introduction. Parkinson's disease (PD) is a neurodegenerative disease with motor and nonmotor symptoms. Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Objectives. To explore how COVID-19 affects motor, nonmotor, and general health aspects of PD and to map how PD patients perceive their change in symptoms since fa

The advent of optogenetic tools has had a profound impact on modern neuroscience research, revolutionizing our understanding of the brain. These tools offer a remarkable ability to precisely manipulate specific groups of neurons with an unprecedented level of temporal precision, on the order of milliseconds. This breakthrough has significantly advanced our knowledge of various physiological and pa

Importance: Alzheimer disease (AD) pathology starts with a prolonged phase of β-amyloid (Aβ) accumulation without symptoms. The duration of this phase differs greatly among individuals. While this disease phase has high relevance for clinical trial designs, it is currently unclear how to best predict the onset of clinical progression. Objective: To evaluate combinations of different plasma biomark

Human carbonic anhydrase II catalyzes the reversible reaction of carbon dioxide and water to form bicarbonate and a proton. His64-mediated proton shuttling between the active site and the bulk solvent is rate limiting. Here we investigate the protonation behavior of His64 as well as its structural and dynamic features in a pH dependent way. We derive two pK a values for His64, 6.25 and 7.60, that

This essay explores the so-called ‘Bomb Plot of Zürich’, in which the Indian nationalists Virendranath Chattopadhyaya and Abdul Hafiz of the Indian Independence Committee collaborated with the German Foreign Office and a band of Swiss-based Italian anarchists led by Arcangelo Cavadini and Luigi Bertoni to smuggle German-manufactured bombs, weapons and poison into Switzerland and Italy in the summe

In this essay the media depictions of the funeral of the former Swedish prime minister Karl Staaff in 1915 are investigated. It shows that, in a pre-democratic state such as early twentieth-century Sweden, media events did not necessarily voice a hegemonic ideology or harmonious sense of community spirit. Rather, mediated public space, even at the commemoration of a former prime minister, could be

En första presentation och analys av målaren Fredrik Vaerslevs konstnärskap

BACKGROUND: Early-stage knee osteoarthritis (KOA) classification criteria will enable consistent identification and trial recruitment of individuals with knee osteoarthritis (OA) at an earlier stage of the disease when interventions may be more effective. Toward this goal, we identified how early-stage KOA has been defined in the literature.METHODS: We performed a scoping literature review in PubM

In this fascinating biography of the Indian revolutionary M. P. T. Acharya (1887–1954), Ole Birk Laursen uncovers the remarkable transnational networks, movements and activities of India’s most important anticolonial anarchist in the twentieth century.Driven by the urge for complete freedom from colonialism, authoritarianism, fascism and militarism, which are rooted in the idea and politics of the

Svensk nazism behandlas ofta som ett enhetligt fenomen. Det saknas i hög grad biografier över ledande företrädare som kan tydliggöra olikheterna mellan dem. Anna-Lena Lodenius har nu avhjälpt detta med avseende på den förste svenska nazistledaren Birger Furugård (1887–1961). Hos honom dominerade det tyska inflytandet, de italienska influenserna lyste med sin frånvaro.

In view of Stuart Hall’s challenge issued in the wake of the 1985 Broadwater Farm riots, this essay aims to locate issues of precarity, racial injustice and rights in Alex Wheatle’s East of Acre Lane (2001) and The Dirty South (2008). Set on council estates in urban areas of London in 1981 and the early 2000s, respectively, these two novels represent and respond to continual legacies of colonialis

Contemporary events have highlighted important connections between technology, globalization and cultural production. Information technologies in particular have impacted the global commodification of information and have led to the significant erosion of national boundaries – for example, through Internet forums and self-broadcasting. Access to these technologies has influenced local and global iden