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Recension av Jeff Guinn, Go Down Together: The True, Untold och Paul Schneider, Go Down Together: The True, Untold.

Differential gene expression in CD177+ and CD177- neutrophils was investigated, in order to detect possible differences in neutrophil function which could be related to the pathogenesis of ANCA-associated Vasculitides (AAV).

Invasive infections of Streptococcus pyogenes are dependent on the cysteine protease streptococcal pyrogenic exotoxin B. Previous structures of the enzyme have not disclosed the proper active-site configuration. Here, the crystal structure of the mature enzyme is presented to 1.55 angstrom, disclosing a homodimer. A serine from one subunit inserts into the active site of the other to donate to the

Symmetry analysis is combined with x-ray scattering experiments to investigate the lattice modulation associated with the incommensurate magnetic structure in the case of a double-k structure. The expansion of the free energy shows that the components of the magnetic structure with propagation vectors k(1) and k(2) can couple via components of lattice modulations. It is shown that the classical di

Here, monoolein-based nanoparticles (NPs), obtained through fragmentation of bulk liquid crystalline phases, and stabilized by two different emulsifiers, namely, Pluronic F127 (PF127) and lauroylcholine chloride (LCh), are investigated for structural features and for short-term in vitro cytotoxicity. Depending on the emulsifiers, different morphologies of the lipid NPs (cubosomes and liposomes) ar

Context. High-resolution spectroscopic surveys of stars indicate that the Milky Way thin and thick discs follow different paths in the chemical space defined by [alpha/Fe] vs. [Fe/H], possibly suggesting different formation mechanisms for each of these structures. Aims. We investigate, using the Gaia-ESO Survey internal Data-Release 2, the properties of the double sequence of the Milky Way discs,

No current commercially available myoelectrically controlled prosthetic hands provide conscious sensory feedback to the user. A system aiming at relocation of sensory input from a prosthetic hand equipped with force sensors to the forearm skin of amputees, a tactile display, has been developed and constructed. The system consists of five piezoresistive force sensors or, alternatively, a prosthetic

Hydrophobic interaction chromatography (HIC) has been used to determine the influence of amino acid substitutions on protein retention and thereby their accessibility on the protein surface. The retentions of mutants of green fluorescent protein (GFPuv) and human hemoglobin (Hb) were studied on multimodal HIC media and compared to the hydrophobicities from known hydrophobicity scales with respect

The aim of this paper is to summarize progress in the development of reflexive methods at Çatalhöyük over the past 20 years, and to describe some recent innovations that have used digital and 3D technologies to enhance the original reflexive aims. While digital technologies were not at the forefront of the methods described in an initial account of reflexive methods published in Antiquity (Hodder

In this paper, we describe an end-to-end system that automatically extracts RDF triples describing entity relations and properties from unstructured text. This system is based on a pipeline of text processing modules that includes a semantic parser and a coreference solver. By using coreference chains, we group entity actions and properties described in different sentences and convert them into en

The intestine represents the body’s largest surface exposed to the outer world and is thus a major entry site for pathogens such as bacteria and viruses. The intestinal immune system has the important task of protecting us against infection while maintaining tolerance against the vast amount of commensal microbes populating the intestinal tract and the multitude of foreign antigen present in the d

Apolipoprotein B (apoB) containing lipoproteins, i.e. VLDL, LDL and Lp(a), are consequently lowered by ACTH treatment in humans. This is also seen as reduced plasma apoB by 20-30% and total cholesterol by 30-40%, mostly accounted for by a decrease in LDL-cholesterol. Studies in hepatic cell line (HepG2) cells showed that apoB mRNA expression is reduced in response to ACTH incubation and is followe

A number of jobs are to be assigned to a greater number of workers. While having to abide by the law of minimum wages, firms must determine who should be assigned which job and at what Salary. In Such situations fair (envy-free) allocations usually fail to exist. To cope with this Situation, this paper proposes a new concept of fairness, called constrained fairness. Among the set of constrainedly

In this work a 2.2 GHz quadrature receiver front-end suitable for low-power applications is presented. The low-noise amplifier, the mixer and the voltage-controlled oscillator are merged into a single stage, making the circuit capable of extreme current reuse while keeping it still functional at low supply voltage. A careful linear time-variant analysis is proven to be necessary to accurately pred

Cytopore is a bead-shaped, macroporous and easily compressible cellulose-based anion-exchange material intended for cultivation of anchor-dependent animal cells. Reticulated vitreous carbon (RVC) is a strong, non-compressible, high voidage (97%) matrix material that can be cut to desired geometrical shapes. Cytopore and RVC were combined to cylindrical composites (25mm 10mm) fitted inside chromato

Ingestion of low-digestible carbohydrates triggers symptoms in patients with irritable bowel syndrome (IBS). These carbohydrates become substrates for microbial fermentation in the colon, yielding short-chain fatty acids (SCFAs) that are readily absorbed. Aiming to compare colonic fermentation in patients with IBS and healthy controls, we analyzed the concentrations of SCFA in serum at fasting and