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Probiotic fruit beverages with different polyphenol profiles attenuated early insulin response

Background: Consumption of polyphenol-rich fruits and vegetables may improve postprandial glucose and insulin levels and hence promote well-being. Previously it has been observed that consumption of bilberry decreases the postprandial insulin demand. The intention with the present study was to compare the impact of different supplements with various polyphenol profiles, on the postprandial glucose

The exterior Calderón operator for non-spherical objects

This paper deals with the exterior Calderón operator for not necessarily spherical domains. We present a new approach of finding the norm of the exterior Calderón operator for a wide class of surfaces. The basic tool in the treatment is the set of eigenfunctions and eigenvalues to the Laplace–Beltrami operator for the surface. The norm is obtained in view of an eigenvalue problem of a quadratic fo

SAMD9 and SAMD9L in inherited predisposition to ataxia, pancytopenia, and myeloid malignancies

Germline mutations in the SAMD9 and SAMD9L genes, located in tandem on chromosome 7, are associated with a clinical spectrum of disorders including the MIRAGE syndrome, ataxia–pancytopenia syndrome and myelodysplasia and leukemia syndrome with monosomy 7 syndrome. Germline gain-of-function mutations increase SAMD9 or SAMD9L’s normal antiproliferative effect. This causes pancytopenia and generally

Claudin-4 Expression is Associated with Survival in Ovarian Cancer but Not with Chemotherapy Response

The tight junction protein claudin-4 has been reported to be overexpressed in advanced ovarian cancer. We investigated the prognostic significance of claudin-4 overexpression and whether claudin-4 expression could predict platinum response in primary ovarian carcinoma (OC). Claudin-4 expression was evaluated by immunohistochemistry in a tissue microarray of 140 OCs. Multivariable Cox-regression mo

Factor V Leiden paradox in a middle-aged Swedish population : A prospective study

Few prospective studies have examined the factor V paradox: factor V Leiden (FVL) is a stronger risk factor for deep venous thrombosis (DVT) than for pulmonary embolism (PE). The present study, to the best of our knowledge, is the first population-based study aimed to examine the relationship between FVL and incidence of venous thromboembolism (VTE), DVT and PE in a prospective cohort study of mid

Hormonal contraception increases the risk of psychotropic drug use in adolescent girls but not in adults : A pharmacoepidemiological study on 800 000 Swedish women

The burden of depression and anxiety disorders is greater in women, and female sex hormones have been shown to affect mood. Psychological side effects of hormonal contraception (HC) are also a common complaint in the clinic, but few previous studies have investigated this subject. We therefore wanted to investigate whether use of HC was associated with adverse psychological health outcomes, and wh

Alkaline sphingomyelinase (NPP7) in hepatobiliary diseases : A field that needs to be closely studied

Alkaline sphingomyelinase cleaves phosphocholine from sphingomyelin, platelet-activating factor, lysophosphatidylcholine, and less effectively phosphatidylcholine The enzyme shares no structure similarities with acid or neutral sphingomyelinase but belongs to ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family and therefore is also called NPP7 nowadays. The enzyme is expressed in the int

Psychotropic drug use as indicator of mental health in adolescents affected by a plexus injury at birth : A large population-based study in Sweden

Chronic handicap in early life may have a long-term impact on children's psychosocial well-being. Here, we investigated whether Brachialis Plexus Birth Injury (BPBI)-an unpredictable injury at birth-is associated with worse mental health later on, as indicated by prescription and use of psychotropic drugs in adolescence. We explored further whether this association is different depending on socioe

Naturliga antal förbättrar förmågan att tolka testresultat

Läkares förmåga att tolka screeningresultat har visats vara bristande.Naturliga antal är ett format att presentera statistik på som kan underlätta den förmågan.Den här studien är först i Sverige att undersöka om naturliga antal förbättrar läkarstudenters förmåga att finna ett testresultats prediktiva värde.74 procent lyckades med uppgiften när naturliga antal användes, jämfört med 54 procent då gäThe ability to draw statistical inferences from test results may be generally limited among physicians. A new way of presenting statistics, called natural frequencies, has been shown to improve this ability. The current study is the first to investigate this effect in Sweden, involving senior medical students. An intra-individual cross-over design was used in which participants answered a statisti

Variables associated with HbA1c and weight reductions when adding liraglutide to multiple daily insulin injections in persons with type 2 diabetes (MDI Liraglutide trial 3)

Objective To evaluate variables associated with hemoglobin A1c (HbA1c) and weight reduction when adding liraglutide to persons with type 2 diabetes treated with multiple daily insulin injections (MDI). Research design and methods This was a reanalysis of a previous trial where 124 patients were enrolled in a double-blind, placebo-controlled, multicenter randomized trial carried out over 24 weeks.

Natural Resources Curse in the Long Run? Bolivia, Chile and Peru in the Nordic Countries’ Mirror

The new estimates of the Maddison Project show that GDP per capita ratio at purchasing power parity (ppp) between Bolivia and Finland has changed from 0.68 ca. 1850 to 0.16 in 2015; similarly, that between Chile and Norway from 0.65 to 0.28. The aim of this article is to present a review of the literature and available quantitative evidence to understand how these extreme differences became possib

Lean ApoM−/− Mice with Hyperactive Brown Adipose Tissue

In Cell Reports, Christoffersen et al. [1] demonstrate that sphingosine 1-phosphate (S1P) bound to apolipoprotein M (apoM) regulates the activity and mass of brown adipose tissue (BAT). They found mice lacking apoM to have hyperactive BAT with high triglyceride (TG) utilization, resulting in low white adipose tissue (WAT) mass and low body weight.

Gut microbiota to counteract metabolic disorders and neuroinflammation : Impact of dietary factors and their potential to prevent Alzheimer’s disease

Alzheimer’s disease (AD) is the most common form of dementia. Increased accumulations of senile plaques and tangles are the known neuropathological hallmarks of AD. However, the exact triggers for such protein accumulations, leading to cognitive impairment and important morphological alteration in AD, are still elusive. Ageing and genetic risk factors do not completely explain the global increase