OBJECTIVES: To evaluate health-related quality of life (HRQoL) and its determinants in a systemic sclerosis (SSc) multinational inception cohort. We performed a meta-analysis of data from individual countries, and compared the meta-analysis to individual country results by pooling data from each of the countries.METHODS: SSc patients within 2 years of disease onset were recruited from 5 countries

Academic training, where senior scientists transfer their knowledge and skills to junior scientists through apprenticeship, plays a crucial role in the development of scientists. This study focuses on two aspects of academic training, autonomy and exploration, to investigate how different modes of training are incentivized and how they affect junior scientists’ performance and career prospects. Dr

METHODS: A cross-sectional analysis of the prospective EULAR Scleroderma Trial and Research database (EUSTAR) was performed. Patients fulfilling preliminary ACR 1980 classification criteria for SSc, with less than 3 years from the first non-Raynaud's symptom at first entry, were selected. A group of patients with less than 3 years from the first SSc symptom, including Raynaud's phenomenon, was als

This essay discusses the commemoration of the Mughal emperor Humayun (r. 1530–40, 1555–56) by his son Akbar (r. 1556–1605), focusing both on Akbar’s practice of visiting the tomb and the way in which these tomb-visits were dealt with by contemporaneous chroniclers. The article shows how Akbar’s chief ideologist, Abu’l Fazl, misrepresented Akbar’s history of visiting his father’s tomb, predating th

The Bahrāmī Safavids, a relatively unknown collateral branch of the Safavid dynasty, active in Iran from 1517 to 1593, played a crucial role in dynastic developments in Safavid Iran. This essay examines the dynastic developments of the Safavid rulers and their contemporaries to argue that they embarked on a process of dynastic centralization, presenting themselves increasingly as the only holder

William I of Nassau, Prince of Orange, and his sons Maurice and Frederick Henry were seen in their own time as the protectors of the new Dutch nation. As such, they play a significant role in the formation of a Dutch national identity. This essay addresses the question in what measure this sentiment was returned: did the Nassaus feel Dutch? An analysis of dynastic arguments used in the Apology (15

In order to generate high voltage high pulsed power, klystron modulators necessarily contain at least one capacitor bank charging structure supplying the energy to be released during the pulse. Conventional charging structures are based on AC/DC front-end units typically based on diode rectifiers combined with on/off controlled power charging structures as a second stage, producing prohibitive lev

High voltage long pulse klystron modulators typically use pulse transformers, where the length of the pulse dictates the size of the transformer. Recent advancements in power electronics applied to modulator technology, in order to facilitate multi-millisecond long pulse generation, instead suggests use of high frequency transformers in a high frequency pulse modulation/demodulation scheme, elimin

Purpose: To model prediction of undetected glaucoma in a predominantly white population, based on intraocular pressure (IOP) and subject age. Methods: In 1992–1997, a population screening for glaucoma was performed at Malmö University Hospital where individuals between 55–79 years of age (n = 46 614) living in Malmö, were invited to a free eye health examination. Recently examined patients were no

Context: Type 2 diabetes mellitus (T2DM) is accompanied by an increased risk for coronary artery disease (CAD), but the overlapping metabolic disturbances preceding both diseases are insufficiently described. Objective:Wehypothesized that alterations in metabolism occur years before clinical manifestation of T2DM and CAD and that these alterations are reflected in the plasma metabolome. We thus ai

Purpose: To describe which types of assistive devices prescribed and actually used, either due to precautions or due to true functional reasons, after hip fracture-related hemiarthroplasty. Materials and methods: About 394 patients cluster-randomized 2010–2014 at a university hospital. Control group with standard postoperative precautions to reduce dislocations, mandatory assistive devices and kne

The human host has evolved elaborate protection mechanisms to prevent infection from the billions of microorganisms to which it host is exposed and is home. One of these systems, complement, is an evolutionary ancient arm of innate immunity essential for combatting bacterial infection. Complement permits the efficient labelling of bacteria with opsonins, supports phagocytosis, and facilitates phag

Klimatförändringarna kommer att påverka ekosystem och samhällen över hela världen. Det är ett problem som kräver drastiska och omedelbara förändringar av vårt sätt att leva och av våra samhällsstrukturer, och därmed politiskt engagemang av aldrig tidigare skådat slag. Under de senaste 30 åren, sedan bildandet av Förenta Nationernas ramkonvention om klimatförändringar (Klimatkonventionen; UNFCCC) åThe rise of climate change as an issue of global concern has rested on scientific representation and understanding of the causes and impacts of, and responses to climatic change. The Intergovernmental Panel on Climate Change (IPCC), in particular, has been central to how climate change has become known as a global political problem. This thesis aims to critically examine the production, negotiatio