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Introduction: This study aimed to investigate the dose-response and pharmacology of a range of single doses of nebulised ensifentrine (RPL554), an inhaled dual phosphodiesterase (PDE) 3/4 inhibitor in patients with asthma. Methods: In this randomised, placebo-controlled, double-blind crossover study, patients received single nebulised doses of ensifentrine 0.4, 1.5, 6 and 24 mg, salbutamol 2.5 and
Super-Earths - planets with sizes between the Earth and Neptune - are found in tighter orbits than that of the Earth around more than one third of main sequence stars. It has been proposed that super-Earths are scaled-up terrestrial planets that also formed similarly, through mutual accretion of planetary embryos, but in discs much denser than the solar protoplanetary disc. We argue instead that t
We consider the problem of grid-forming control of power converters in low-inertia power systems. Starting from an average-switch three-phase power converter model, we draw parallels to a synchronous machine (SM) model and propose a novel converter control strategy which dwells upon the main characteristic of a SM: the presence of an internal rotating magnetic field. In particular, we augment the
We propose a novel control strategy for grid-forming converters in low-inertia power grids. Our strategy is inspired by identifying the structural similarities between the 3-phase DC/AC converter and the synchronous machine model. We explicitly match these models through modulation control so that they become structurally equivalent. Compared to standard emulation of virtual synchronous machines,
This paper formulates and addresses the problem of equivalence in terms of multistability properties between nonlinear models of gene regulatory systems of different dimensionality. Given a nonlinear dynamical model of a gene regulatory network and the structure of another higher-dimensional gene regulatory network, the aim is to find a dynamical model for the latter that has the same equilibria a
If experience is the guiding light in entrepreneurship education, then why is there so little mention of a philosophy of experience? This article aims to illuminate the philosophical foundations upon which entrepreneurship education rests by discussing learning through experience. In particular, we discuss the concept of experience used in educational research and learning activities for fostering
A search for high-mass dielectron and dimuon resonances in the mass range of 250 GeV to 6 TeV is presented. The data were recorded by the ATLAS experiment in proton–proton collisions at a centre-of-mass energy of s=13 TeV during Run 2 of the Large Hadron Collider and correspond to an integrated luminosity of 139 fb−1. A functional form is fitted to the dilepton invariant-mass distribution to model
The crystalline lens of the vertebrate eye grows throughout life. This growth may be enormous in fish, while the lens must be functional from larva to adult. During growth, the fiber cells of the lens must increase the concentration of specific proteins (crystallins) in the cytoplasm to increase refractive index. However, the bulk of the fiber cells in a vertebrate lens are denucleated and have no
Report for Tillväxtverket – the Swedish Agency for Economic and Regional Growth.
A key assumption conventionally made by flexible head-mounted eye-tracking systems is often invalid: The eye center does not remain stationary w.r.t. the eye camera due to slippage. For instance, eye-tracker slippage might happen due to head acceleration or explicit adjustments by the user. As a result, gaze estimation accuracy can be significantly reduced. In this work, we propose Grip, a novel g
Det småskaliga fisket längs Östersjökusten minskar idag i snabb takt. Det finns mångamöjliga orsaker till utvecklingen. En som uppmärksammats är de växande sälstammarna i Östersjön eftersom de konkurrerar med människan om fiskresursen. Både det kustnära fisket och sälen är viktiga delar av Östersjöns kultur- och naturliv, men de senasteårens utveckling tyder på att det är svårt för småskaligt fisk
Under the Sign of Regret focuses on aesthetically mediated responses to regret. It interrogates the qualities of the feeling of regret as well as what is produced under its influence (as objects and as experiences). These two aims—considering regret as a mode and as a tool—hinge between two complementary definitions of aesthetics: on the one hand, the quality of feelings or the “distribution of th
Asymmetric flow field-flow fractionation (AF4) is a separation technique in which a focusing/relaxation step is used after the sample is injected onto the separation channel. During the focusing/relaxation step, the sample is focused by two counter-directed flows. This allows sample components to establish a diffusion-dependent equilibrium concentration profile. The focusing step may, in some case
Background: Genome-wide association studies (GWAS) have identified >50 single nucleotide polymorphisms (SNP) in association with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD) but little is known about whether the combination of these SNPs may aid in prediction of future incidence of CKD in the population. Methods: We included 2301 participants with baseline eGFR ≥60
With advancing age, changes in the arterial wall contribute to what has been called vascular aging, and in some prematurely affected subjects even early vascular aging (EVA).1–5 Several years ago,1 we listed various components of EVA, including arteriosclerosis, atherosclerosis, and excess vasoconstriction, with their clinical expression: arterial stiffening and increased central pulse pressure, c
The aim of this article was to investigate presentations of “wet” eldercare facilities in Sweden, a type of facility that provides care for older people with long-term alcohol problems and where the consumption of alcohol is allowed. Wet eldercare facilities challenge traditional Swedish policy on alcohol treatment, and their approach constitutes a breach of mainstream policies on alcohol and trea
