BACKGROUND: The acquisition of drug resistance is a major reason for poor outcome of neuroblastoma. Protein kinase C (PKC) has been suggested to influence drug resistance in cancer cells. The aim of this study was to elucidate whether inhibition of PKCbeta isoforms influences drug-resistance of neuroblastoma cells. METHODS: The effect of the PKCbeta inhibitor LY379196 on the growth-suppressing eff

Repeated resistivity measurement is a potentially powerful method for monitoring development of internal erosion and anomalous seepage in earth embankment dams. This study is part of a project to improve current longterm monitoring routines and data interpretation and increasing the understanding when interpreting existing data. This is accomplished by modeling various occurrences typical of emban

This paper addresses a problem for theories of epistemic democracy. In a decision on a complex issue which can be decomposed into several parts, a collective can use different voting procedures: Either its members vote on each sub-question and the answers that gain majority support are used as premises for the conclusion on the main issue (premise based-procedure, pbp), or the vote is conducted on

On the Swedish artistis Dick Bengtsson, Elis Eriksson and Jarl Hammarberg and their role in the introduction of installation art in Sweden.

The spectroscopic data mercury (Hg) I and Hg II was analyzed from beam-foil spectroscopy. The wavelength was found to be of course fixed and independent of the light source and recording conditions. It was found that if the calculated branching ratio was correct, then the Hg II was an important constituent of fluorescent light tube plasmas. The wavelength region from 40 to 600 nm in overlapping wa

While the scientist-practitioner model of training has enjoyed wide-spread appeal, difficulties in implementing the model have continued since its inception. Despite these difficulites, we remain advocates of the model and believe responsibility for inculcating a scientist-practitioner mindset rests with both training programs and trainees themselves. Thus, we offer several suggestions for both tr

Oral and pharyngeal function in 131 institutionalized elderly patients with advanced dementia was evaluated by means of videofluoroscopic deglutition examination (VDE). Findings were normal in only nine (7%) patients. Oral-stage dysfunction was observed in 93 (71%) patients, pharyngeal dysfunction in 56 (43%), and pharyngoesophageal-segment abnormalities in 43 (33%). Multiple-stage dysfunction was

Due to uncertainties regarding clinically meaningful gains from adjuvant chemotherapy after colorectal cancer surgery, several Nordic Groups in the early 1990s initiated randomised trials to prove or reject such gains. This report gives the joint analyses after a minimum 5-year follow-up. Between October 1991 and December 1997, 2 224 patients under 76 years of age with colorectal cancer stages II

Background/Aims: Budesonide controlled-release (CR) capsules are effective for inducing remission of Crohn's disease (CD) and are associated with fewer side effects than conventional corticosteroids. A compassionate-use program was implemented in countries where this treatment was unavailable. This paper reports the findings of this program. Methodology: Physicians were allowed to apply to AstraZe

Starting from the German pitch peak timing categories and their communicative functions, it is asked how these functions would be expressed in South Swedish. The aim is to get a first impression as regards potentially relevant prosodic parameters associated with the expression of expected vs. unexpected information in South Swedish. For that, an interactive manipulation experiment is conducted, wh

Abstract is not available

Antibodies are critical entities used for the protection of an individual organism against infection and disease. Through a complex series of events genes rearrange to encode repertoires of molecules, which are tested for their ability to identify foreign molecules. In this report, we discuss factors defined by the individual as well as by infectious organisms that shape the antibody repertoire. A

The article examines some of the tradition answers to the questions what differs Judaism from Christianity, comparing those from antiquity to answers articulated during the 19th and 20th centuries. It is argued that representatives of Christianity constantly need to examine traditional answers. The encounter with living Judaism is essential, with the words of Leo Baeck: "Man muss die Juden kennen,

Abstract Background and ObjectiveFluorescence techniques can provide powerful noninvasive means for medical diagnosis, based on the detection of either endogenous or exogenous fluorophores. The fluorescence of δ-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) has already shown promise for the diagnosis of tumors. The aim of the study was to investigate the localization of skin tumors a