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Secretory granule exocytosis and its amplification by cAMP in pancreatic β-cells

The sequence of events for secreting insulin in response to glucose in pancreatic β-cells is termed “stimulus-secretion coupling”. The core of stimulus-secretion coupling is a process which generates electrical activity in response to glucose uptake and causes Ca2+ oscillation for triggering exocytosis of insulin-containing secretory granules. Prior to exocytosis, the secretory granules are mobili

Current and future costs of obesity in Sweden

Background: Obesity is a growing health issue. This study estimated the costs of obesity among people aged 25–84 years in Sweden using disease and non-disease specific attributable fractions from published data. A prognosis of costs of obesity in 2030 is presented. Methods and materials: Diseases related to obesity and their respective risks and population attributable fraction were retrieved by l

Poor intake of vitamins and minerals is associated with symptoms among patients with irritable bowel syndrome

Background and Aim: Poor food habits with insufficient intake of micronutrients have been described in irritable bowel syndrome (IBS), which could be of importance for development of gastrointestinal and extraintestinal symptoms. The study aims were to examine intake and plasma/serum levels of micronutrients in IBS and whether these factors were associated with symptoms and restrictions and to stu

Understanding young people’s perception toward forestation as a strategy to mitigate climate change in a post-conflict developing country

Understanding the perceptions of young people is a critical issue in the formulation and implementation of climate change mitigation strategies. Based on cognitive hierarchy theory, the present study aims to investigate the factors that motivate or hinder young people’s perception of forestation as a strategy to mitigate climate change in post-conflict Somalia. This study hypothesized a model in w

In Situ Study of Zinc Peroxide Decomposition to Zinc Oxide by X-Ray Absorption Spectroscopy and Reverse Monte Carlo Simulations

The Zn K-edge X-ray absorption spectroscopy is used to investigate in situ the decomposition of zinc peroxide ((Formula presented.)) to zinc oxide (ZnO). Principal component and linear combination analyses of the extended X-ray absorption fine structure (EXAFS) spectra are employed to identify the phase composition of the oxide upon heating to 900 °C. Only the (Formula presented.) phase is found u

Reviewing a plethora of oxidative-type reactions catalyzed by whole cells of Streptomyces species

Selective oxidation reactions represent a challenging task for conventional organic chemistry. Whole-cell biocatalysis provides a very convenient, easy to apply method to carry out different selective oxidation reactions including chemo-, regio-, and enantio-selective reactions. Streptomyces species are important biocatalysts as they can catalyze these selective reactions very efficiently owing to

Risk Factors for Complicated Mohs Surgery in the South Sweden Mohs Cohort

Background: Mohs micrographic surgery (MMS) is a precise, tissue-sparing surgical technique that offers superior cure rates compared to traditional surgical excision. However, the degree of difficulty of MMS depends on many variables, and consequently, the number of surgical stages required for each case is quite unpredictable.Objectives: To identify risk factors for complicated MMS, defined as MM

Physical and social environmental factors related to co-occurrence of unhealthy lifestyle behaviors

Previous work identifying determinants of co-occurrence of behavioral risk factors have focused on their association with individuals' characteristics with scant attention paid to their relationship to contextual factors. Data came from 21,007 individuals ≥15 years of age who participated in the cross-sectional 2011-2012 Spanish National Health Survey. Two indicators were defined by tobacco consum

Multilevel analysis of birthplace effect on the proportion of C-Section in Colombia"

Objectives: To determine the general contextual effect of the department in the variation of Cesarean section in Colombia in 2016, and their individual and contextual related factors.Methods: Cross-sectional study based on a birth cohort. We used the birth certificate database from January 1 to December 31, 2016. Three multilevel logistic models were constructed. Pregnant women were set at the fir

1500-talets Lund ur ett nytt perspektiv

I det omfattande geografiska verket Civitates orbis terrarum från slutet av 1500-talet avbildas bland ett stort antal europeiska städer även ett fåtal nordiska, däribland Lund i form av ett kopparstick av Franz Hogenberg, en bild som har diskuterats tidigare, ofta tillsammans med en nära samtida kartskiss i Anders Vedels samlingar. Författaren gör här en djupanalys och nytolkning av denna bild, oc

Tower Houses in Medieval Scanian Towns

Towers in medieval towns is something normally connected to southern Europe. In Scandinavia, towers are seen as something belonging to castles and residences in the countryside, not to urban milieus. However, they are to be found even in Scandinavian towns. In this paper the existence of private urban tower houses in medieval Scania will be presented and discussed, and a hypothesis about a previou

The Technopolitics of Compassion : A Postphenomenological Analysis of the Digital Mediation of Global Humanitarianism

Humanitarian organisations are central actors in the mediation of humanitarian disasters as objects of public, political and moral concern. Consequently, if we want to understand this key dynamic of world politics we have to understand how aid organisations use media. But whereas extant knowledge about media and global humanitarianism focuses primarily on issues related to discourses and images of