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Acquired aplastic anemia (AA) is considered to be an autoimmune mediated disease whereas in inherited bone marrow failure syndromes the genetic abnormalities account for the bone marrow dysfunction. The only curative treatment for inherited AA is hematopoietic stem cell transplantation (HSCT). Successful treatment for acquired AA has traditionally been considered with HSCT, whereas single agent th
objectives: To assess the level of infectious complications and the impact of timing of a single, prophylactic, oral dose of ciprofloxacin 750 mg given either 2 hours before or in conjunction with ultrasound -guided core biopsy of the prostate in men without recognised risk factors and to analyse potential risk factors. Methods: All men undergoing prostate biopsy for elevated prostate specific ant
Indices of mineral metabolism in blood and urine were analysed in relation to blood pressure in 97 healthy subjects aged 16-82 years. In a multivariate analysis, after allowing for the effects of sex, body mass index (BMI) and age, there was an inverse relationship between plasma level of ionized calcium and mean blood pressure (MBP) (beta = -50.0 mmHg/mmol/l P-ionized calcium, p = 0.0005). In uni
Dating the transgression and subsequent regression in marginal basins of the southeastern Swedish Baltic Sea provides a new perspective of global ice-volume changes and the isostatic adjustment of the mantle after the retreat of the Scandinavian Ice Sheet from this area. Superimposed upon a smooth pattern of local sea-level rise, acceleration occurred ca. 7600 calibrated (cal) yr B.P., evidenced a
The alpha-adrenoceptor-mediated contractile effects of noradrenaline (alpha 1 + alpha 2), phenylephrine (alpha 1) and clonidine (alpha 2) on human saphenous veins were investigated in vivo and in vitro. By infusion (0.3 ml min-1) of the drugs (increasing concentrations in the infused solution) into distended (40 mmHg) saphenous veins in six healthy subjects, local vasoconstriction was induced, mea
Thirty-five varieties of the green pea (Pisum sativum L.) were analysed for their total antioxidant capacity (TAC. After blanching and freezing, the water-soluble fraction had, on average, a TAC of 0.61(0.22) mumol/g (mean(SD)) and the water-insoluble fraction a value of 0.23(0.08) mumol/g. There was a significant correlation between the TAC in the water-soluble and water-insoluble fractions (r =
In nuclear medicine imaging, single photon emission computed tomography (SPECT) is used with increasing frequency for studies of different organs. A new approach is to use quantitative SPECT for dose planning in radionuclide therapy. Important parameters to estimate dose planning are described here.
The predictive value of distal blood pressure measurements for the level of amputation was studied prospectively in 161 consecutive diabetic patients with foot ulcers. The patients were treated as outpatients except for periods of surgery and when complications requiring hospital care occurred. All patients were treated pre- and postoperatively by the same multidisciplinary foot care team. Either
PURPOSE: To describe a component-based aortomonoiliac stent-graft system and the first clinical results achieved with this device in endovascular abdominal aortic aneurysm (AAA) repair. METHODS: From November 1993 to October 1996, 45 patients aged 60 to 86 years underwent endoluminal exclusion of true AAAs (median diameter 60 mm) involving the common iliac arteries (median diameter 16 mm right and
The lifetimes of the 21/2(+) and 17/2(-) yrast states in Nb-89, Mo-89 and Tc-91 and of the 334 keV 5/2(-) state in Nb-87 were determined via the electronic timing method. The nuclei were populated by means of the VICKSI pulsed Ar-36 beam impinging on a Ni-58 target. The lifetimes measured for the first time are: Mo-89: 2271 keV 17/2(-) tau = 1.6(4) ns; 2584 keV 21/2(+) tau = 13.7(3) ns; Nb-87: 334
The compatibility between the implementation of information and communication technologies (ICTs) strategies and the bottom-up approach in the developmental process is assessed. In order to put the theoretical arguments into practice, the existing benefits and obstacles of implementing such strategies in reality are presented. Deriving from the analysis of the bottom-up approach is the identificat
The very large multiplicity of charged particles encountered in lead on lead collisions in the WA98 experiment at the CERN SPS provided new experimental challenges. Tracking detectors read out with high granularity were developed to achieve accurate position information in two dimensions, with the aim of reconstructing tracks with a minimum of combinatorial difficulties. A tracking system based on
Secretagogin is a newly identified calcium-binding protein selectively expressed in neuroendocrine tissue and pancreatic beta-cells. The function of secretagogin is unknown, but it has been suggested in beta-cells to influence calcium-influx, insulin secretion and proliferation, and has been observed downregulated in diabetes-prone BB rat islets exposed to cytokines. In the present study, we ident
Povidon är en polymer som används som stabiliseringsmedel i många läkemedel och vissa kosmetika. Povidon har ansetts vara atoxiskt och inte allergiframkallande. Vi beskriver ett fall av överkänslighet mot povidon som nyligen rapporterats till biverkningsenheten i Lund. Vi har även gjort en litteratursökning och sammanfattar tidigare publicerade fall. Allergi mot povidon har dokumenterats med prick
LTH har, tillsammans med KTH och VTI, med Vägverket och Kommunikationsforskningsberedningen som finansiärer, i uppdrag att utveckla nya modeller för effektberäkning av vägtrafikanläggningar. Som en del i detta arbete görs en inventering av kunskapsläge och kunskapsbrister. Redovisningen av detta avseende framkomlighet i korsningar utan trafiksignaler görs i denna rapport. Ca 200 referenser har stu
The nucleotide sequences of the variable region genes encoding five different human, high affinity antibodies, specific for the major neutralization determinant (AD-1) expressed by human cytomegalovirus glycoprotein B (gp58/116), have been determined. Three of the five heavy chain variable regions belonged to the small VHV-family, although they combined with a diverse set of light chains (V kappa
