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Carcinoma-in-situ of the testis - Is ultrasound of the testes useful as a screening method?

Testicular germ cell cancer is preceded by a pre-invasive stage called carcinoma-in-situ (CIS). The majority, if not all cases of CIS will progress into invasive cancer. Today, the only reliable way of diagnosing CIS is by performing open testicular biopsy. There is an ongoing search for non-invasive techniques for diagnosing early testicular neoplasia. The possibility of using ultrasound of the t

Semen quality in relation to xenohormone and dioxin-like serum activity among inuits and three european populations

BACKGROUND: Semen quality in humans may be influenced by exposure to endocrine-disrupting compounds. OBJECTIVES: We analyzed associations between semen characteristics and serum xenoestrogen receptor (XER), xenoandrogen receptor (XAR), and aryl hydrocarbon receptor (AhR) transactivity. XER and XAR activity were measured in serum samples cleared for endogenous steroid hormones and AhR activity in r

Xenoandrogenic activity in serum differs across European and inuit populations

BACKGROUND: Animal and in vitro studies have indicated that human male reproductive disorders can arise as a result of disrupted androgen receptor (AR) signalling by persistent organic pollutants (POPs). Our aim in the present study was to compare serum xenoandrogenic activity between study groups with different POP exposures and to evaluate correlations to the POP proxy markers 2,2',4,4',5,5-hexa

Facing metaphors as the most complex iconic signs: Toward a synthetic analysis of figuration in Greek street art

Cognitive linguistic and semiotic accounts of metaphors have often discussed the complex phenomenon of metaphor in various ways, often addressing factors such as universality and conventionality, context-sensitivity, cross-cultural variation and creativity, deliberateness and “multimodality”. However, in most cases, such factors are investigated in isolation (cf. Gibbs 2017). Therefore, we propose

Brain myoinositol as a potential marker of amyloid-related pathology : A longitudinal study

ObjectiveTo investigate the association between longitudinal changes in proton magnetic resonance spectroscopy (MRS) metabolites and amyloid pathology in individuals without dementia, and to explore the relationship between MRS and cognitive decline.MethodsIn this longitudinal multiple time point study (a subset of the Swedish BioFINDER), we included cognitively healthy participants, individuals w

Renal function after out-of-hospital cardiac arrest; The influence of temperature management and coronary angiography, a post hoc study of the target temperature management trial

Background: To elucidate the incidence of acute kidney injury (AKI) after out-of-hospital cardiac arrest (OHCA) and to examine the impact of target temperature management (TTM) and early coronary angiography on renal function. Methods: Post hoc analysis of the TTM trial, a multinational randomised controlled trial comparing target temperature of 33 °C versus 36 °C in patients with return of sponta

Interaction between smoking and genetic factors in the development of chronic bronchitis

Rationale: Smoking is a primary risk factor for chronic bronchitis, emphysema, and chronic obstructive pulmonary disease, but since not all smokers develop disease, it has been suggested that some individuals may be more susceptible to exogenous factors, such as smoking, and that this susceptibility could be genetically determined. Objectives: The aim of the present study was to assess, in a popul

Minskade utsläpp räcker inte för att rädda mångfalden

Klimatfrågan har under senare år rotat sig in i svenskens medvetande. Om detta vittnar nyord som ”klimatångest” och ”flygskam”. Det är på tiden. Men klimatförändringarna är inte den enda kris vi nu står inför och måste konfrontera.

Lexical frequency effects on word accent processing in Swedish

Lexical frequency effects on word accent processing in SwedishSeveral studies have investigated the neurophysiological underpinnings of the Swedish word accents, “accent 1” and “accent 2” ([1]-[5]), which are known to have a strong association with morphology ([6]-[8]). For example, if the singular noun suffix -en is attached to the word stem bil (‘car’), the resulting word is bil1-en (‘the car’)

coreMRI: A high-performance, publicly available MR simulation platform on the cloud

IntroductionA Cloud-ORiented Engine for advanced MRI simulations (coreMRI) is presented in this study. The aim was to develop the first advanced MR simulation platform delivered as a web service through an on-demand, scalable cloud-based and GPU-based infrastructure. We hypothesized that such an online MR simulation platform could be utilized as a virtual MRI scanner but also as a cloud-based, hig

Lower extremity function in patients with early rheumatoid arthritis during the first five years, and relation to other disease parameters

Objective: The objective of this study was to investigate lower extremity function in early rheumatoid arthritis (RA) and assess its relation to other disease parameters. Methods: An inception cohort (recruited in 1995–2005) of patients with early RA was followed according to a structured protocol. Lower extremity function was investigated at inclusion and after 1, 2, and 5 years using the Index o