Background: Girls adopted from developing countries often have early or precocious puberty, requiring treatment with gonadotrophin-releasing hormone (GnRH) analogues. During such treatment, decreased growth velocity is frequent. Aim: To study whether the addition of growth hormone (GH) to GnRH analogue treatment improves final height in girls with early or precocious puberty. Methods: Forty-six gi

The aim of this work was to investigate sorting mechanisms of von Willebrand factor (VWF) when expressed in haematopoietic cells. The processing and sorting of both the wild-type VWF and a multimerization defective propeptide-mutant (VWFm) were investigated after expression in the 32D cell line. Normal proteolytic processing was observed for both proteins, however the processing of VWFm was much s

Popular Abstract in Swedish Celldöd är en lika viktig process som celldelning. Under hela ens liv måste vävnadens storlek regleras och gamla eller skadade celler förnyas. Detta styrs av en process som kallas programmerad cell död. Denna process är noggrant reglerad så att enbart oönskade celler tas bort. Om regleringen sätts ur funktion leder detta till ohämmad celldelning och cancer. Ett problem HAMLET (Human alpha-lactalbumin made lethal to tumor cells) is a molecular complex of alpha-lactalbumin and oleic acid, that induces programmed cells death in tumor cells but leaves healthy differentiated cells unaffected. It has a broad anti-tumor activity as more than 40 cell lines from different origin are sensitive. The cell death activity of HAMLET is retained in vivo. HAMLET limits the progr

A readily releasable pool (RRP) of granules has been proposed to underlie the first phase of insulin secretion. In the present study we combined electron microscopy, insulin secretion measurements and recordings of cell capacitance in an attempt to define this pool ultrastructurally. Mouse pancreatic B-cells contain approximately 9,000 granules, of which 7% are docked below the plasma membrane. Th

The functional role of aerobic lactate production in the rat portal vein was investigated. Changing substrate from glucose (11.5 mM) to pyruvate (11.5 mM) or beta-hydroxybutyrate (3 mM) had virtually no effect on spontaneous mechanical activity. Lactate production (FLA) was smaller with pyruvate than with glucose (0.05 +/- 0.01 vs. 0.14 +/- 0.03 mumol g-1 min-1, n = 4). Addition of 0.5 mM iodoacet

Popular Abstract in Swedish Detta är en avhandling om hur en del av vårt meningsskapande går till, sedd genom åtta studenters användning av sina kontextuella resurser. Den handlar om hur vi lyssnar till auditiva, visuella och upplevda röster, och hur vi talar med stöd av dessa röster när vi skapar och utvecklar vår egen röst. Detta kallar jag för rapporterat lyssnande, d.v.s. dessa yttranden visarThis thesis has two points of departure and four main purposes. The first point of departure concerns the narrow perspective of the listening skill in Swedish. The first purpose is to show the lack of attention to the listening skill in research and mother tongue education in the Swedish compulsory school. Educational documents from 1842 to 2000 about Swedish as a school subject are examined from

The near-field radiation pattern of a long thin slit (with a width much smaller than the excitation wavelength) in a uniform aluminum surface was measured and modeled by numerical computation. In particular, the interplay between the incident light polarization and the slit width is found to play an essential role in the near-field profile on the back side of the nanoslits. Two-dimensional finite-

1 The study was performed to clarify if apomorphine at the level of the rat corpus cavernosum can produce erectile responses or interfere with nerve-induced penile erection. 2 Apomorphine ( 10(-9) - 10(-4) M) exhibited a 10-fold higher potency to relax phenylephrine ( Phe)-than endothelin-1 ( ET-1)-induced contractions. Relaxant effects of apomorphine in Phe-activated corpus cavernosum did not cha

In this work the Arrhenius parameters and heat of reaction for the esterification of acetic anhydride by methanol and the esterification of propionic anhydride by 2-butanol were determined using a CPA 202 reaction calorimeter (ChemiSens). Three reaction rate models were tested for each of the esterification reactions, two of which assumed autocatalytic behaviour. The autocatalytic models were base

By collecting distances from the literature, a set of 73 planetarynebulae with mean distances of high accuracy is derived. This sample isused for recalibration of the mass-radius relationship, used by manystatistical distance methods. An attempt to correct for a statisticalpeculiarity, where errors in the distances influences the mass-radiusrelationship by increasing its slope, has been made for t

Eae5 in rats was originally identified in two F-2 intercrosses, (DA x BN) and (E3 X DA), displaying linkage to CNS inflammation and disease severity in experimental autoimmune encephalomyelitis (EAE), respectively. This region overlaps with an arthritis locus, Pia4, which was also identified in the (E3 X DA) cross. Two congenic strains, BN.DA-Eae5 and BN.DA-Eae5.R1, encompassing the previously des