BACKGROUND: Smartphones have made it possible for patients to digitally report symptoms before physical primary care visits. Using machine learning (ML), these data offer an opportunity to support decisions about the appropriate level of care (triage).OBJECTIVE: The purpose of this study was to explore the interrater reliability between human physicians and an automated ML-based triage method.METH

Global forests are the main component of the land carbon sink, which acts as a partial buffer to CO2 emissions into the atmosphere. Dynamic vegetation models offer an approach to projecting the development of forest carbon sink capacity in a future climate. Forest management capabilities are important to include in dynamic vegetation models to account for the effects of age and species structure a

Three different carbohydrate prosthetic groups associated to three chymotryptic peptides, Q1, Q2 and Q3, were isolated from the reduced and carboxymethylated human protein HC. The first oligosaccharide forms an O-glycosidic linkage with a threonine residue at position 5 in the polypeptide chain of protein HC. The second and third carbohydrate prosthetic groups form N-linkages with asparagine resid

A miniaturized flow-injected thermal biosensor was developed for the determination of urea and L-lactate in undiluted blood in 1-μL samples. The sensor employed a small enzyme column constructed of stainless steel tubing and microbead thermistors. Urease and lactate oxidase/catalase were separately immobilized onto controlled-pore glass beads, which, in turn, were charged into the enzyme column. W

Fast determination of whole blood glucose without any pretreatment was achieved using a calorimetric FIA micro-biosensor. Glucose oxidase was covalently immobilized, together with catalase, onto controlled pore glass beads and packed into a micro-column. By reducing the sample volume down to 1 μ1, a measurement period of about 40 s and an enlarged linear range of 0.5-20 mM glucose were obtained. T

Background Prior research suggested a differential association of 25-hydroxyvitamin D (25(OH)D) metabolites with type 2 diabetes (T2D), with total 25(OH)D and 25(OH)D3 inversely associated with T2D, but the epimeric form (C3-epi-25(OH)D3) positively associated with T2D. Whether or not these observational associations are causal remains uncertain. We aimed to examine the potential causality of thes

A series of experimental measurements on a prototype premixed swirl burner with complex geometry were carried out using CH2O/OH-PLIF. FGM method(SFGM)taking account of strain rate was developed to study two modes of premixed swirl flame, one stabilized and the other close to blown-off flame under the same Reynolds number(Re=10000). The SFGM model in this work is related to a reaction factor, which

Most flying animals rely primarily on visual cues to coordinate and control their trajectory when landing. Studies of visually guided landing typically involve animals that decrease their speed before touchdown. Here, we investigate the control strategy of the stingless bee Scaptotrigona depilis, which instead accelerates when landing on its narrow hive entrance. By presenting artificial targets t

Protein HC (alias alpha 1-microglobulin) contains so far unidentified yellow-brown fluorescent chromophores. Several preparations of human protein HC were extracted with hexane. Most of the extracts contained a substance which, upon reversed-phase HPLC, co-eluted with all-trans- retinol and had an absorption spectrum identical to that of retinol. The substance was also, like retinol, destroyed by

Objective: Papillary urothelial neoplasm of low malignant potential (PUNLMP) and stage TaG1 non-muscle invasive bladder cancer (NMIBC) represent separate categories in current WHO 1999 grade definitions. Similarly, PUNLMP and Ta low-grade are separate entities in the WHO 2004/2016 grading system. However, this classification is currently questioned by reports showing a similar risk of recurrence a

A biosensor that combines electrochemistry and calorimetry was investigated. Using this sensor, glucose measurements were performed by employing glucose oxidase together with ferrocene as electron-transfer mediator. The electrochemical reaction was accomplished by applying a voltage between a platinum column (working electrode), in contact with a crushed reticulated vitreous carbon (RVC) matrix on

Intrinsically disordered proteins are involved in many biological processes such as signaling, regulation, and recognition. A common strategy to regulate their function is through phosphorylation, as it can induce changes in conformation, dynamics, and interactions with binding partners. Although phosphorylated intrinsically disordered proteins have received increased attention in recent years, a

The location of the West African craton (WAC) has been poorly constrained in the Paleoproterozoic–Mesoproterozoic supercontinent Nuna (also known as Columbia). Previous Nuna reconstruction models suggested that the WAC was connected to Amazonia in a way similar to their relative position in Gondwana. By an integrated paleomagnetic and geochronological study of the Proterozoic mafic dikes in the An

Background: Minimally invasive radical trachelectomy has emerged as an alternative to open radical hysterectomy for patients with early-stage cervical cancer desiring future fertility. Recent data suggest worse oncologic outcomes after minimally invasive radical hysterectomy than after open radical hysterectomy in stage I cervical cancer. Objective: We aimed to compare 4.5-year disease-free surviv

The glucose concentration in diluted whole blood has been measured, using a miniaturized thermal biosensor based on the enzyme thermistor principle. The biosensor is a small flow-injection system. A sample volume of 20μ1 is injected into a flow of 50μl/min. The heat produced when the sample passes the enzyme column is measured with a thermistor connected to a Wheatstone bridge. The enzyme column c

We present stellar parameters, stellar ages, and detailed elemental abundances for Na, Mg, Al, Si, Ca, Ti, Cr, Fe, and Ni for 32 solar sibling candidates. Technique of chemical tagging gives us a high probability that four stars might be from the same open cluster. Only one candidate HIP 40317 which has solar metallicity and age could be a solar sibling. We performed simulations of the Sun's birth