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Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with a pathogenesis involving a dysfunctional blood-brain barrier and myelin-specific, autoreactive T cells. Although the commensal microbiota seems to affect its pathogenesis, regulation of the interactions between luminal antigens and mucosal immune elements remains unclear. Herein, we investiga

Artikeln belyser det messianska stråket hos Emmanuel Levinas och argumenterar för att det kan ses i ljuset av Maimonides rationalistiska messianism.

Impaired learning and memory are common symptoms of neurodegenerative and neuropsychiatric diseases. Present, there are several behavioural test employed to assess cognitive functions in animal models, including the frequently used novel object recognition (NOR) test. However, although atypical functional brain lateralization has been associated with neuropsychiatric conditions, spanning from schi

In the debate about how to interpret Violation-of-Expectation (VoE) based false-belief experiments, it has been suggested that infants are predicting the actions of the agent based on more or less sophisticated cognitive means. We present an alternative, more parsimonious interpretation, exploring the possibility that the infants’ reactions are not governed by rational expectation but rather of me

Background: Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Recent studies delineate a possible role of this enzyme in blood pressure (BP) maintenance and cardiac protection and two single nucleotide polymorphisms, RNLS rs2576178 A > G and rs2296545 C > G have been associated with hypertension. The latter

Complexes formed by one charged and branched copolymer with an oppositely charged and linear polyion have been investigated by Monte Carlo simulations. A coarse-grained description has been used, in which the main chain of the branched polyion and the linear polyion possess the same absolute charge and charge density. The spatial extension and other structural properties, such as bond-angle orient

Context:Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T). Objective:The objective of the study was to seek objective biochemical and end-organ evidence of androgen deficiency in men classified as having LOH according to our previously published criteria. Design, Setting, and Participants:The des

Background and purpose A questionnaire was introduced by the New Zealand Arthroplasty Registry for use when evaluating the outcome of total ankle replacement surgery. We evaluated the reliability, validity, and responsiveness of the modified Swedish version of the questionnaire (SEFAS) in patients with osteoarthritis or inflammatory arthritis before and/or after their ankle was replaced or fused.

Locus Celebris – the Church, Monastery and Manor of Dalby actualized: An introduction to the common view on Dalby, to the research history and mediation of the place, to the international conference 24-27 April 2011 in Dalby and finally also an introduction to the conference publication.

Is it possible to determine the Facebook Gemeinschaft or the living law of the global file sharing community? What are the social facts of twitter or the intuitive law of Chinese microbloggers? This paper argues that digitization of society, the reliance on digital networks, protocol, algorithms and completely new sets of organisational structures for social communities, have vast implications for

Resistivity in horizontal boreholes can give useful detailed information about the geological conditions for construction in rock, i.e. in front of a tunnel bore machine. This paper is an attempt to identify a suitable methodology for an effective measuring routine for this type of geophysical measurements under actual construction site conditions. Prior to any measurements numerical modelling was

Reinforced concrete is one of the most widely used building materials and if it is properly designed and produced, it is an extremely durable material with a service life up to 100 years. However, under certain environmental conditions the service life of reinforced concrete structures is more limited. Deterioration of concrete structure is in most cases caused by the penetration of aggressive med

En av de verkligt stora frågorna i den samtida retorikteorin är förhållandet till det klassiska arvet. Retoriken kan sägas vara det moderämne i den humanistiska bildningstraditionen som många ämnen inom humaniora har avknoppats från, och därför är det inte lika självklart att det nya är bättre än det gamla när retorikforskare ser på sitt eget ämne. Andrea A.Lunsford är en av de ledande retorikfors

Life-history theory predicts that individuals should adjust their reproductive effort according to the expected fitness returns on investment. Because sexually selected male traits should provide honest information about male genetic or phenotypic quality, females may invest more when paired with attractive males. However, there is substantial disagreement in the literature whether such differenti

We evaluated the seasonality of CO2 fluxes simulated by nine terrestrial ecosystem models of the TRENDY project against (1) the seasonal cycle of gross primary production (GPP) and net ecosystem exchange (NEE) measured at flux tower sites over different biomes, (2) gridded monthly Model Tree Ensembles-estimated GPP (MTE-GPP) and MTE-NEE obtained by interpolating many flux tower measurements with a

Patients with vascular dementia (VaD) exhibit particularly elevated levels of plasma total homocysteine (tHcy) compared to patients with other psychogeriatric diseases.

Vikings routinely crossed the North Atlantic without amagnetic compass and left their mark on lands as far away as Greenland, Newfoundland and Baffin Island. Based on an eleventh-century dial fragment artefact, found at Uunartoq in Greenland, it is widely accepted that they sailed along chosen latitudes using primitive Sun compasses. Such instruments were tested on sea and proved to be efficient h