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A novel thermometric biosensor for fast surveillance of beta-lactamase activity in milk

Regulatory restrictions on antibiotic residues in dairy products have resulted in the illegal addition of beta-lactamase to lower antibiotic levels in milk in China. Here we demonstrate a fast, sensitive and convenient method based on enzyme thermistor (ET) for the surveillance of beta-lactamase in milk. A fixed amount of penicillin G, which is a specific substrate of beta-lactamase, was incubated

Sanktionerat motstånd : Brukarinflytande som fenomen och praktik

Frågan om brukarinflytande inom välfärdssektorn har sin grund i de krav på humanisering, demokratisering och maktdelning som höjdes av den ideella brukarrörelsen på 1960- och 70-talet. I dag har tanken om brukarinflytande anammats av det offentliga och de krav på inflytande som tidigare höjdes av en social rörelse utifrån och underifrån, drivs nu politiskt inifrån och uppifrån inom den offentliga The roots of the idea of user involvement within social services can be found in the efforts of the rising service user movement in the 1960s and 70s. Today the concept of “service user involvement” has been adopted by the state and is widespread within political rhetoric’s as well as in human service practices. However, user involvement is known to be an imprecise phenomenon that can take on diff

Isocyanide in Biochemistry? A Theoretical Investigation of the Electronic Effects and Energetics of Cyanide Ligand Protonation in [FeFe]-Hydrogenases

The presence of Fe-bound cyanide ligands in the active site of the proton-reducing enzymes [FeFe]-hydrogenases has led to the hypothesis that such Bronsted-Lowry bases could be protonated during the catalytic cycle, thus implying that hydrogen isocyanide (HNC) might have a relevant role in such crucial microbial metabolic paths. We present a hybrid quantum mechanical/molecular mechanical (QM/MM) s

Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma.

We previously reported a disease segregating causal germline mutation in a melanoma family and recurrent somatic mutations in metastasized tumours from unrelated patients in the core promoter region of the telomerase reverse transcriptase (TERT) gene. Here we show that the TERT promoter mutations, besides causing an increased gene expression, associate with increased patient age, increased Breslow

Predicting hygrothermal performance in cold roofs using a 1D transient heat and moisture calculation tool

Stricter Swedish building regulations require a moisture safety design process to be carried out before houses are built. In order to predict moisture-critical conditions, a properly verified, user-friendly and reliable calculation tool that could be used in this design phase, is required. This paper initially presents a blind method that could be used in order to verify hyg-rothermal calculation

Apolipoprotein M predicts pre-beta-HDL formation: studies in type 2 diabetic and nondiabetic subjects

Objective. Studies in mice suggest that plasma apoM is lowered in hyperinsulinaemic diabetes and that apoM stimulates formation of pre-beta-HDL. Pre-beta-HDL is an acceptor of cellular cholesterol and may be critical for reverse cholesterol transport. Herein, we examined whether patients with type 2 diabetes have reduced plasma apoM and whether apoM is associated with pre-beta-HDL formation and ce

ATLAS search for a heavy gauge boson decaying to a charged lepton and a neutrino in pp collisions at root s=7 TeV

The ATLAS detector at the LHC is used to search for high-mass states, such as heavy charged gauge bosons (W'), decaying to a charged lepton (electron or muon) and a neutrino. Results are presented based on the analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 4.7 fb(-1). No excess beyond Standard Model expectations is observed. A W' with Seq

Study of in Vitro and in Vivo Bone Formation in Composite Cryogels and the Influence of Electrical Stimulation.

This work studies osteoinduction and bone conduction in polyvinyl alcohol-tetraethylorthosilicate-alginate-calcium oxide (PTAC) biocomposite cryogels along with the synergistic effect of electrical stimulation. In vitro osteoinduction of C2C12 myoblast towards osteogenic lineage is demonstrated through alkaline phosphatase assay, scanning electron microscopy and energy dispersive X-ray spectroscop

Non-invasive diagnostics of the maxillary and frontal sinuses based on diode laser gas spectroscopy

Problem: Suspected, but objectively absent, rhinosinusitis constitutes a major cause of visits to the doctor, high health care costs, and the over-prescription of antibiotics, contributing to the serious problem of resistant bacteria. This situation is largely due to a lack of reliable and widely applicable diagnostic methods. Method: A novel method for the diagnosis of rhinosinusitis based on non

Poly-substance use and antisocial personality traits at admission predict cumulative retention in a buprenorphine programme with mandatory work and high compliance profile

Background: Continuous abstinence and retention in treatment for alcohol and drug use disorders are central challenges for the treatment providers. The literature has failed to show consistent, strong predictors of retention. Predictors and treatment structure may differ across treatment modalities. In this study the structure was reinforced by the addition of supervised urine samples three times

Framgångspotential. Egenskapsfaktorer vid rekryteringen av bibliotekarier. Slutrapport

Projektet Framgångspotential är en kartläggning av vissa professionella attityder och personliga egenskaper hos 2000-talets bibliotekarier. Kartläggningen gjordes 2001-2002. Den övergripande forskningsfrågan rör hurdana medarbetare biblioteken behöver under de kommande 10-20 åren. Projektet syftade till att med utgångspunkt från en lista över 34 personliga egenskaper kartlägga och analysera dels a

Public Corruption in Swedish Municipalities - Trouble Looming on the Horizon?

In the 1990s, several public corruption scandals were uncovered in Sweden. This article focuses specifically on local corruption, and our purpose is to examine whether a case can be made that problems of public corruption in Swedish municipalities have increased. By applying instruments from the institutional rational choice framework, we reach the conclusion that there are indeed reasons to suspe

Parrhesia and credibility: the covereign of refugee status determination

This article is concerned with the correlation between credibility and the concept of sovereignty in international law and their relationship to truth. Empirically, the authors focus on the credibility assessment informing the refugee determination procedure operated by the Office of the UN High Commissioner of Refugees. The authors do not provide a rationalised explanation of credibility assessme

Kinin System Activation in Vasculitis

The kinin system is activated when high-molecular-weight kininogen (HK) is cleaved by plasma kallikrein thus generating bradykinin. Bradykinin is a potent proinflammatory peptide that induces plasma leakage, blood pressure drop, liberation of inflammatory cytokines and pain. Vasculitis is an autoimmune systemic inflammatory disease, characterized by leukocyte inflammation in and around vessel wall

Development of Safety-Critical Software Systems Using Open Source Software - A Systematic Map

The popularity of Open Source Software (OSS) has increased the interest in using it in safety critical applications. The aim of this study is to review research carried out on usage of open source code in development of safety-critical software and systems. We conducted a systematic mapping study through searches in library databases and manual identification of articles from open source conferenc