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Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34+ cord blood hematopoietic stem cells using a clinically applicable lentiviral vector

Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure disorder in which pure red blood cell aplasia is associated with physical malformations and a predisposition to cancer. Twentyfive percent of patients with DBA have mutations in a gene encoding ribosomal protein S19 (RPS19). Our previous proof-of-concept studies demonstrated that DBA phenotype could be successfully treated using len

Commodification of recreational hunting in Sweden : hunting tourism experiences as ‘peculiar goods’

IntroductionRecreational hunting in Sweden can be depicted as being embedded in two different but overlapping cultural and socio-economic contexts. One is the traditional non-commercial and stewardship-oriented form hunting, in Swedish called ‘allmoge’ hunting. It is characterised by a democratic hunting tradition where the local hunting team is ascribed a main role in wildlife management. These tThe paper is based on a study of hunting tourism enterprising in Sweden. The study examines how hunting tourism businesses in Sweden navigate in a complex social, economic and moral environment. The aim of the present paper is to identify how tensions between a market- oriented value sphere and a value sphere based on friendship- and community reciprocity are played out in hunting tourism entrepre

Ett digitaliserat Sverige : en studie om digitalisering och krav vid kommunala museer

The aim of this master thesis is to examine how institutional rules and demands, present in cultural politics, affects the work with digitalisation in local museums. According to narrative trends in Sweden’s national cultural politics, digitalisation has the potential to encourage and increase democracy by enabling participation and wider access. Therefore, digitisation practices in cultural insti

Urbana Hängsel + Tornhuset=sant? Två byggnader i en komplicerad relation

This bachelor thesis examines the relationship between two buildings situated at Universitetsholmen in Malmö: Tornhuset (1910) and its modern extension Urban Hinges (2015). Together, the two buildings form World Maritime University. The modern extension has received a great deal of attention, both positive and negative, in traditional as well as in social media. Several statements suggest that vi

A landscape level analysis of entrepreneurship and sustainable energy transitions : Evidences from Gujarat, India

In accordance with India's sustainable energy targets of achieving 175 GW of renewable energy (RE) installed capacity by 2022 and 450 GW by 2030, the role of private sector actors has become increasingly important. As presently, 96 percent of the total installed RE utilities in India are privately owned; this makes sustainability driven entrepreneurship the core of India's energy sector transition

Towards a conceptual understanding of sustainability-driven entrepreneurship

In common discourse, economic activities run by profit-oriented managers and entrepreneurs are considered to be at the root of social and ecological crisis and hence, hamper sustainable development. With this perspective, government, policymaking institutions, and civil societies take the center stage in shaping a sustainability-oriented industry by using the tools of command and control to curb t

Identification and characterization of murine glycoprotein 2-expressing intestinal dendritic cells

The intestinal lamina propria (LP) contains distinct subsets of classical dendritic cells (cDC), each playing key non-redundant roles in intestinal immune homeostasis. Here, we show that glycoprotein 2 (GP2), a GPI-anchored protein and receptor for bacterial type-I fimbriae, is selectively expressed by CD103+CD11b+ cDC in the murine small intestine (SI). GP2 expression was induced on CD103+CD11b+

Diglyphomorphomyia Girault (Chalcidoidea: Eulophidae) new to the Neotropical region including nine new species

the genus Diglyphomorphomyia Girault is newly reported from the Neotropical region, with the majority of material and species from Costa rica. It is represented by nine species in the region, and all are new species described here: D. albiclava, D. albicoxa, D. carinifer, D. costulata, D. cristata, D. metallica, D. parva, D. pedunculata, D. pilosa. An identification key for the species is included

Full-scale aerobic granular sludge for municipal wastewater treatment – granule formation, microbial succession, and process performance

Aerobic granular sludge (AGS) plants have gained growing interest and application due to their low energy demand, small footprint, and low operational costs. However, the fulfilment of strict discharge limits for nitrogen and phosphorus, vast seasonal temperature variations, and large peaks in influent flows may pose challenges to the implementation of AGS. Moreover, the knowledge about microbial

A survey on thromboprophylaxis and coagulation assessment in children and young adults with acute lymphoblastic leukaemia (ALL) in the Nordic and Baltic countries : Different practices of assessment and management

Patients undergoing treatment for acute lymphoblastic leukaemia (ALL) are at risk of coagulopathy, especially thromboembolism. We conducted a survey on practices in the assessment and management of coagulopathy during the new ALLTogether protocol in 29 (17 paediatric, 12 adult) Nordic and Baltic cancer centres. While 92% of adult centres used thromboprophylaxis with low-molecular-weight heparin, n

Outcomes of cataract surgery complicated by posterior capsule rupture in the European Registry of Quality Outcomes for Cataract and Refractive Surgery

PURPOSE: To analyze the outcomes of cataract surgery complicated by posterior capsule rupture (PCR). SETTING: European clinics affiliated to the European Registry of Quality Outcomes for Cataract and Refractive Surgery (EUREQUO). DESIGN: Retrospective cross-sectional register-based study. METHODS: Data were retrieved from the EUREQUO between January 1, 2008, and December 31, 2018. The database con

An accurate fully automated panel of plasma biomarkers for Alzheimer's disease

Introduction: There is a great need for fully automated plasma assays that can measure amyloid beta (Aβ) pathology and predict future Alzheimer's disease (AD) dementia. Methods: Two cohorts (n = 920) were examined: Panel A+ (n = 32 cognitively unimpaired [CU], n = 106 mild cognitive impairment [MCI], and n = 89 AD) and BioFINDER-1 (n = 461 CU, n = 232 MCI). Plasma Aβ42/Aβ40, phosphorylated tau (p-