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I gränslandet mellan genotyp och fenotyp : motsägelser i samband med prediktiv genetisk testning

Utvecklingen inom genetiken har möjliggjort att prediktiva genetiska tester kan utföras för ett antal mer eller mindre svåra sjukdomstillstånd. Det innebär att individer kan få reda på att de är bärare av ett sjukdomsanlag innan detta anlag ger upphov till konkreta och klara symptom. I spåren av dessa test uppstår ett gränsland mellan vad de genetiska testresultaten visar och uppkomsten av tydliga

The Language of Failure: The Use of Accounts in Financial Reports

The natural language that accompanies the accounting language in financial reports is not only a more or less accurate representation of the company but also, the authors argue, a response to explicit as well as implicit external demands, expectations, and accusations. Drawing on the notion of accounts (i.e., statements or responses that neutralize critique of not meeting expectations), the author

Search for the Standard Model Higgs boson produced in association with top quarks and decaying into in collisions at with the ATLAS detector

A search for the Standard Model Higgs boson produced in association with a top-quark pair, , is presented. The analysis uses 20.3 fb(-1) of pp collision data at , collected with the ATLAS detector at the Large Hadron Collider during 2012. The search is designed for the decay mode and uses events containing one or two electrons or muons. In order to improve the sensitivity of the search, events are

High-Level Architecture Modeling and Exploration for Streaming Applications

Multi and many core platforms are increasingly employed today to cope with the demands of modern multimedia, networking and other similar streaming applications. Selecting the best architecture for a set of such applications is complex, and without coding for each specific system, the choice is made based on designer experience. In this paper we use CAL, a dataflow language for specifying streamin

Modern Staging in Primary Breast Cancer-aspects of micrometastatic disease in bone marrow and molecular profiles in lymph node metastases

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerdiagnosen hos svenska kvinnor, ca 8000 tumörer diagnosticeras årligen. Vid rekommendation om behandling till patienter med nyupptäckt bröstcancer utgår man från ett antal prognostiska (risk för återfall och död utan behandling) och prediktiva (risk för återfall och död med specifik behandling) faktorer. Ålder, tumörstorlek, cancercellBreast cancer is a heterogeneous disease with variations in the biological profile and subsequent clinical prognosis. Molecular mechanisms for tumour progression are currently being explored in scientific settings, suggesting parallel evolution of tumour cells at primary and metastatic locations. The molecular profiles could be altered affecting individual patient’s treatment and prognosis. In the

"It is meaningful; I feel that I can make a difference" -A qualitative study about GPs' experiences of work at nursing homes in Sweden

Background: Swedish nursing homes (NH) have limited capacity. As a result elderly people living in NH represent the part of the elderly population in most need of care. In Sweden a General Practitioner (GP) is usually responsible for the medical care of all subjects living in a NH. The residents in NH seldom have adequate pharmacological treatment according to diagnosis and often have polypharmacy

Complement activation and plasma levels of C4b-binding protein in critical limb ischemia patients.

OBJECTIVE: Critical limb ischemia (CLI) is a peripheral arterial disease manifested by drastically diminished blood flow to the legs, pain at rest, nonhealing wounds, and gangrene caused by atherosclerosis. Significant tissue necrosis is associated with late stage CLI and the patients have a poor prognosis. Necrotic and apoptotic cells activate complement and bind complement inhibitor C4b-binding

Spectral characterisation of dairy products using photon time-of-flight spectroscopy

In this paper, we present, for the first time, the absorption and reduced scattering spectra of commercially available milk and yoghurt products, obtained using photon-time-of-flight spectroscopy. The ability of this technique to separate the contributions from absorption and scattering in the sample provides important information on the chemical composition and micro-structural properties, which

Low-frequency scattering analysis and homogenisation of split-ring elements

A key structure in so-called metamaterial mediums is the elementary split-ring resonator. We consider in this paper the low-frequency electromagnetic scattering by a split-ring particle modelled as a perfectly conducting wire ring, furnished with a narrow gap, and derive analytical solutions for the electric and magnetic dipole moments for different kinds of incidence and polarisation in the quasi

Faster data structures and graphics hardware techniques for high performance rendering

Computer generated imagery is used in a wide range of disciplines, each with different requirements. As an example, real-time applications such as computer games have completely different restrictions and demands than offline rendering of feature films. A game has to render quickly using only limited resources, yet present visually adequate images. Film and visual effects rendering may not have st

Can planetary instability explain the Kepler dichotomy?

The planet candidates discovered by the Kepler mission provide a rich sample to constrain the architectures and relative inclinations of planetary systems within approximately 0.5 AU of their host stars. We use the triple-transit systems from the Kepler 16 months data as templates for physical triple-planet systems and perform synthetic transit observations, varying the internal inclination variat

Impact of Lifestyle, Hormones, and Genes on Breast Cancer

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen hos kvinnor i Sverige. Årligen drabbas 7000 kvinnor i Sverige och cirka 1500 kvinnor dör av sin sjukdom. Bröstcancer uppkommer genom ett samspel mellan livsstil, miljö och gener. En kvinna som har en förstagradssläkting (t.ex. syster, mor) med bröstcancer har ungefär dubbelt så stor risk att drabbas av bröstcancer jämfört med eApproximately 7000 women are diagnosed and 1500 women die from breast cancer in Sweden every year. The aim of this thesis was to study the interplay of polymorphisms, hormone levels, lifestyle, and the use of concomitant medication in relation to risk and prognosis in two cohorts: one composed of young healthy women from high-risk breast cancer families and the other of breast cancer patients fro

Många nyheter bland skånska blommossor.

Based on revision of c. 200 collections of Schistidium made during the ongoing survey of the bryophyte flora of the province of Skåne, it is concluded that although S. apocarpum (s.str.) and S. crassipilum are by far the most frequent species a fair number of other taxa occure in the province. Thus, single collections of four species not previously documented from the province, viz. S. boreale, S.