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To sustain their proliferation, cancer cells become dependent on one-carbon metabolism to support purine and thymidylate synthesis. Indeed, one of the most highly upregulated enzymes during neoplastic transformation is MTHFD2, a mitochondrial methylenetetrahydrofolate dehydrogenase and cyclohydrolase involved in one-carbon metabolism. Because MTHFD2 is expressed normally only during embryonic deve
Thiopurines are a standard treatment for childhood leukemia, but like all chemotherapeutics, their use is limited by inherent or acquired resistance in patients. Recently, the nucleoside diphosphate hydrolase NUDT15 has received attention on the basis of its ability to hydrolyze the thiopurine effector metabolites 6-thio-deoxyGTP (6-thio-dGTP) and 6-thio-GTP, thereby limiting the efficacy of thiop
The highly poisonous botulinum neurotoxins, produced by the bacterium Clostridium botulinum, act on their hosts by a high-affinity association to two receptors on neuronal cell surfaces as the first step of invasion. The glycan motifs of gangliosides serve as initial coreceptors for these protein complexes, whereby a membrane protein receptor is bound. Herein we set out to characterize the carbohy
3-Methyl-1,2,3-butanetricarboxylic acid (MBTCA) is a secondary organic aerosol and can be used as a unique emission marker of biogenic emissions of monoterpenes. Seasonal variations and differences in vegetation cover around the world may lead to low atmospheric MBTCA concentrations, in many cases too low to be measured. Hence, an important tool to quantify the contribution of terrestrial vegetat
For a firm in an open source software (OSS) ecosystem, the requirements engineering (RE) process is rather multifaceted. Apart from its typical RE process, there is a competing process, external to the firm and inherent to the firm’s ecosystem. When trying to impose an agenda in competition with other firms, and aiming to align internal product planning with the ecosystem’s RE process, firms need
Context: In the Requirements Engineering (RE) process of an Open Source Software (OSS) community, an involved firm is a stakeholder among many. Conflicting agendas may create miss-alignment with the firm's internal requirements strategy. In communities with meritocratic governance or with aspects thereof, a firm has the opportunity to affect the RE process in line with their own agenda by gaining
The geophysical characteristics of the carbonate-dominated Ordovician succession is described using wire-line logging data from exploration wells located within the Swedish part of the Baltic Basin, both offshore and from the island of Gotland. The petrophysical properties and log-motifs are compared and correlated with the lithology of cores from the Hamra-10, Skåls-1 and Grötlingbo-1 wells on s
Background: Patients with first-time myocardial infarction (MI) and diabetes mellitus (DM) constitute a vulnerable subgroup of cardiovascular (CV) patients for which secondary prevention is particularly important. We investigated if patients with versus without DM differ in attaining four main lifestyle-related cardiac rehabilitation (CR) targets, one-year post-MI. Methods: This national cohort st
This article puts contemporary debates about the relationship between immigration policy and the welfare state in historical perspective. Relying on new historical data, the article examines the relationship between immigration policy and social policy in Western Europe in the late 19th and early 20th centuries, when the modern welfare state emerged. Germany already had comparably strict immigrati
Drawing on fieldwork in a multi-ethnic workplace (an industrial kitchen in Denmark), this article explores immigrants' self-directed ethnic humor in collegial relationships with Danes as it spontaneously develops and plays out in everyday work settings. Approaching ethnic humor from a symbolic interactionist perspective rather than adopting the dominant conflict approach, this article emphasizes t
Background and purpose — Patient-reported outcome (PRO) in total knee arthroplasty (TKA) patients with high body mass index (BMI) is controversial. We compared pain, function, quality of life, general health, and satisfaction among different BMI categories preoperatively and 1 year after primary TKA. Patients and methods — 4,318 patients were operated with a TKA for knee osteoarthritis in the Regi
We introduce a new type of random walk where the definition of edge repellence/reinforcement is very different from the one in the “traditional” reinforced random walk models and investigate its basic properties, such as null versus positive recurrence, transience, as well as the speed. The two basic cases will be dubbed “impatient” and “ageing” random walks.
To transport their balls of dung along a constant bearing, diurnal savannah-living dung beetles rely primarily on the sun for compass information. However, in more cluttered environments, such as woodlands, this solitary compass cue is frequently hidden from view by surrounding vegetation. In these types of habitats, insects can, instead, rely on surrounding landmarks, the canopy pattern, or wide-
For older people using long-term care services, the conditions of their life-space may be critical. The relationships between the physical housing environment and aspects of health were examined among older people in Japan (aged 65+ years, N = 1,928) by multivariable logistic regression analysis, adjusting for sociodemographic characteristics. Lack of safety, low access to emergency assistance, lo
BackgroundImproved quality of life (QoL) is one of the most important objectives in the treatment of epilepsy. Recent prospective, clinical studies proved no significant differences between brand antiepileptic drugs (AEDs) and their generic equivalents in terms of seizure control, pharmacokinetics, or safety. In this study, we focused on possible changes in QoL and adverse events in connection wit
Estimating the 3D model of the human body is needed for many applications. However, this is a challenging problem since the human body inherently has a high complexity due to self-occlusions and articulation. We present a method to reconstruct the 3D human body model from a single RGB-D image. 2D joint points are firstly predicted by a CNN-based model called convolutional pose machine, and the 3D
In this paper we consider trajectory recovery for two cameras directed towards the floor, and which are mounted rigidly on a mobile platform. Previous work for this specific problem geometry has focused on locally minimising an algebraic error between inter-image homographies to estimate the relative pose. In order to accurately track the platform globally it is necessary to refine the estimation
This paper studies the long-term behaviour of a continuous time Markov chain formed by two non-negative integer valued components that evolve subject to a competitive interaction. In the absence of interaction the Markov chain is just a pair of independent linear birth processes with immigration. Interactions of interest include, as a special case, the famous Lotka-Volterra interaction. The Markov
Carl Wellman (1971) introduced the reasoning-type conduction while en-dorsing a dialectical view on natural lan-guage argumentation. Contemporary schol-arship, by contrast, treats conductive argu-ment predominantly on a product view. Not only did Wellman's reasons for a dialectical view thereby fall into disregard; a product-treatment of conduction also flouts the standard semantics of 'argument'.
