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Refsum disease (RD) is an inborn error of metabolism that is characterised by a defect in peroxisomal α-oxidation of the branched-chain fatty acid phytanic acid. The disorder presents with late-onset progressive retinitis pigmentosa and polyneuropathy and can be diagnosed biochemically by elevated levels of phytanate in plasma and tissues of patients. To date, no cure exists for RD, but phytanate

A pulsed millimeter wave radar operating at a frame rate of 144 Hz is utilized to record 2160 scattering signatures of 12 generic hand gestures. Gesture recognition is achieved by machine learning, utilizing transfer learning on a pretrained convolutional neural network. This yields excellent classification results with a validation accuracy of 99.5%, based on a 60% training versus 40% validation

The radiotherapy workflow for prostate cancer is associated with systematic uncertainty stemming from the registration between the computed tomography (CT) and magnetic resonance (MR) images. A radiotherapy workflow based solely on MR imaging (MRI), called an MRI-only workflow, has been suggested as a means of eliminating this uncer¬tainty. The aim of the work presented in this thesis was to valid

Postscript to a small volume with poems by Hungarian poet Daniel Dányi (b. 1981)

The rhizosphere priming effect (RPE), which occurs in the presence of growing plant roots, may either stimulate or reduce the decomposition of soil organic matter (SOM). The carbon and nitrogen cycling in forest soils could be more rapid or slower due to the RPE, depending on the tree species and their growing conditions. Norway spruce (Picea abies) and Scots pine (Pinus sylvestris) are two commer

Category-based induction is an inferential mechanism that uses knowledge of conceptual relations in order to estimate how likely is for a property to be projected from one category to another. During the last decades, psychologists have identified several features of this mechanism, and they have proposed different formal models of it. In this article; we propose a new mathematical model for categ

Migratory waterbirds require an effectively conserved cohesive network of wetland areas throughout their range and life-cycle. Under rapid climate change, protected area (PA) networks need to be able to accommodate climate-driven range shifts in wildlife if they are to continue to be effective in the future. Thus, we investigated geographical variation in the relationship between local temperature

Centrifugal sedimentation of an ideal suspension in a rotating tube or basket can be modelled by an initial-boundary-value problem for a scalar conservation law with a nonconvex flux function. The sought unknown is the volume fraction of solids as function of radial distance and time for constant initial data. The method of characteristics is used to construct entropy solutions. The qualitatively

BACKGROUND: It is still not clear whether anastomotic leakage after anterior resection for rectal cancer affects long-term functional outcome. OBJECTIVE: This study aimed to evaluate how anastomotic leakage following anterior resection for rectal cancer influences defecatory, urinary, and sexual function. DESIGN: In this retrospective population-based cohort study, patients were identified through

AbstractThis thesis investigates the use of digital resources in education with a 1-1 computer to student ratio. Studies were performed with a sociocultural perspective and in the light of the theory of affordances. The two studies differ methodologically but the shared topic is teachers’ usage of digital resources. Previous studies have shown that using digital resources to promote collaboration,

Tidal inlets are narrow channels connecting coastal lagoons to the sea and in this way controlling the exchange of water while serving as navigational pathways. These important components of the coast are also very dynamic environments, having their morphology determined by multiple sediment transport processes, making tidal inlets difficult to model. Expected future sea level rise imposes an adde

This thesis contributes to econometric methodology in terms of estimation and inference in static panel data models with unobserved multidimensional heterogeneity. When not properly accounted for, unobserved heterogeneity may introduce bias into the parameter estimates associated with covariates of interest, such as treatment indicators or determinants of macroeconomic indicators. A common way of

Huntington disease (HD) is a hereditary neurodegenerative disorder caused by an expanded cytosine–adenine–guanine triplet repeat in the huntingtin gene. The current diagnosis is based on the presence of typical motor signs in combination with a positive gene test. The motor onset of the disease is usually between 30 and 50 years of age, and the disease then progresses over around 20 more years. No

The antibody drug conjugate trastuzumab-emtansine (T-DM1) offers an additional treatment option for patients with HER2-amplified tumors. However, primary and acquired resistance is a limiting factor in a significant subset of patients. Hypoxia, a hallmark of cancer, regulates the trafficking of several receptor proteins with potential implications for tumor targeting. Here, we have investigated ho

Two methods for reconstructing intragranular strain fields are developed for scanning three-dimensional X-ray diffraction (3DXRD). The methods are compared with a third approach where voxels are reconstructed independently of their neighbours [Hayashi, Setoyama & Seno (2017). Mater. Sci. Forum, 905, 157-164]. The 3D strain field of a tin grain, located within a sample of approximately 70 grain