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Abnormal collagen fibrils in tendons of biglycan/fibromodulin-deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis

Small leucine-rich proteoglycans (SLRPs) regulate extracellular matrix organization, a process essential in development, tissue repair, and metastasis. In vivo interactions of biglycan and fibromodulin, two SLRPs highly expressed in tendons and bones, were investigated by generating biglycan/fibromodulin double-deficient mice. Here we show that collagen fibrils in tendons from mice deficient in bi

Mot en ny arbetsorganisering: en sociologisk studie av några försöksprojekt med flexibla arbetstider och distansarbete inom Malmö kommun

I denna rapport får vi följa sex arbetsplatser inom Malmö kommun som under ett och ett halvt år utprovar olika typer av alternativa arbetstidsmodeller. Inom vård och barnomsorg utprovas flexibla bemanningsscheman, inom VA-service utprövas årsarbetstid och bland socialsekreterare och utredare utprovas distansarbete. Utprovningarna sker inom ramen för kommunens personalpolicy som bl a fokuserar ett

Leachability testing of sludge from street gullies

Sludge from gullies, on two types of streets with different traffic intensity, was investigated using two recommended EU methods for leachability testing of waste: a two-stage batch test and an up-flow percolation test. The main purpose of this investigation was to gain more knowledge about these leaching test methods to be able to make future decisions on the general applicability of the proposed

Biodiversity and its assessment in boreal and nemoral forests

We review species richness in major organism groups, mainly using examples from northern Europe. A high proportion of these species is forest living, and large numbers are dependent on decaying wood. Biodiversity can be assessed at various scales using two different principles. One is to use features. such as ancient and dead trees, known to be important for a large number of species. The other me

Cubic phases and cubic phase dispersions in a phospholipid-based system

A cubic liquid crystalline phase forming system based on the phospholipid dioleoylphosphatidylethanolamine (DOPE) which is fortified with small amounts of PEGylated (poly(ethylene) glycol) glycerol monooleate (PEG(660)-GMO) is characterized. The cubic phase formed by the DOPE/PEG(660)-GMO/water system coexists with water in the dilute part of the phase diagram and can be fragmented into colloidal

Selective supercritical fluid extraction to identify aged sediment-bound PCBs available for uptake by eel

A naturally contaminated sediment was partially extracted with selective supercritical fluid extraction (SFE) to remove a fraction of supposedly bioavailable PCBs from the matrix. Eels (Anguilla anguilla) were cultured in systems with untreated and pre-extracted sediment, respectively, and it was shown that the SFE treatment selectively removed bioavailable PCBs from the sediment, since relative b

Iterative channel estimation and data detection in frequency-selective fading MIMO channels

Signals transmitted through multiple-input multiple-output (MIMO) wireless channels buffer from multiple-access interference (MAI), multipath propagation and additive noise. Iterative multiuser algorithms mitigate these signal impairments. while offering a good tradeoff between performance and complexity. The receiver presented in this paper performs channel estimation. multiuser detection and dec

Subgraph counts in random graphs using incomplete U-statistics methods

The random graph Kn,p is constructed on n labelled vertices by inserting each of the (n2) possible edges independently with probability p, 0> p < 1. For a fixed graph G, the threshold function for existence of a subgraph of Kn,p isomorphic to G has been determined by Erdös and Rényi [8] and Bollobás [3]. Bollobás [3] and Karo ski [14] have established asymptotic Poisson and normal convergence for

Patient-relevant outcomes fourteen years after meniscectomy : influence of type of meniscal tear and size of resection

OBJECTIVES: To study long-term patient-relevant outcomes after meniscectomy, a surgical procedure associated with a high risk of knee osteoarthritis (OA). Principal objectives were to compare traumatic with degenerative meniscal tear and partial with subtotal meniscectomy.METHODS: We studied a well-defined cohort of 205 patients who had undergone isolated unilateral meniscectomy between 1983 and 1

rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration

The thesis is focused on an attempt to delay photoreceptor cell death in the rd1 mouse using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse model displays a reti

Descriptive study and pharmacotherapeutic intervention in patients with epilepsy or Parkinson's disease at nursing homes in southern Sweden.

OBJECTIVES: To describe the drug use in epilepsy and Parkinson's patients living in nursing homes and to evaluate the impact of multi-speciality team intervention on health-related quality of life, activities of daily living (ADL) and confusion state. METHODS: Nursing home residents with epilepsy or Parkinson's disease in the county of Skåne in Sweden were identified. From 119 nursing homes, 262 p