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EMA Review of Daratumumab (Darzalex) for the Treatment of Adult Patients Newly Diagnosed with Multiple Myeloma
The use of daratumumab in combination with established regimens for the treatment of newly diagnosed multiple myeloma has recently been authorized by the European Medicines Agency based on results from three separate phase III randomized, active controlled, open-label studies that have confirmed enhanced efficacy and tolerability in both transplant-ineligible (MMY3008 and MMY3007) and transplant-e
Structural Health Monitoring and Management with Unmanned Aerial Vehicles : Review and Potentials
Den perfekta stormen. Kan EU-arbetsrätten sänka Sjöräddningssällskapet?
Frivilligarbete har efter ett par avgöranden i EU-domstolen kommit under särskild belysning också av Parlamentet. Rättspraxis har skjutit frivilligarbete allt närmare definitionerna av anställning och förvärvsarbete, i vart fall avseende vissa bestämmelser. Artikeln konstaterar att frivilligarbete är ett betydande del av det svenska civilsamhället - exempelvis organiseras i princip all sjöräddning
The role of women's emotional profiles in birth outcome and birth experience
OBJECTIVE: The aim was to investigate birth outcome and birth experience in relation to women's emotional heslth. An additional aim was to explore the relationship between emotional health, continuity with a known midwife, and the birth experience.METHODS: A prospective longitudinal cohort study of 243 women enrolled in a continuity of care project in a rural area in Sweden. Profiles were construc
A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner
Activation of AMP-activated protein kinase (AMPK) is considered a valid strategy for the treatment of type 2 diabetes. However, despite the importance of adipose tissue for whole-body energy homeostasis, the effect of AMPK activation in adipocytes has only been studied to a limited extent and mainly with the AMP-mimetic 5-aminoimidazole-4-carboxamide-1-b-d-ribofuranoside (AICAR), which has limited
Wind and Wood : Affordances of Musical Instruments: The Example of the Simple-System Flute
The aim of this doctoral dissertation is to explore and describe the relationship and interaction between musicians and their instruments. In order to achieve a high level of detail, a certain instrument is in focus: the simple-system flute. Although primarily developed as a product of 19th-century Western art music, this instrument has since become established in other genres and traditions.EmpirThe aim of this doctoral dissertation is to explore and describe the relationship and interaction between musicians and their instruments. In order to achieve a high level of detail, a certain instrument is in focus: the simple-system flute. Although primarily developed as a product of 19th-century Western art music, this instrument has since become established in other genres and traditions.Empir
”Vi måste förbereda oss för att antibiotika slutar fungera”
Authenticity, copying and the critical gaze : The crisis of representation
AbstractIn contemporary western theatre and actor’s training there is a tension between different traditions in the actor’s work, concerning the bodily practices that are related to representation, construction of identities, authenticity and self-expression. One aspect of the actor’s methodical tradition – the openness for suffering and sacrificing oneself in the name of the arts – will be displaIn contemporary Western theatre and actor’s training, there is a tension between different traditions in the actor’s work, concerning the bodily practices that are related to representation, construction of identities, authenticity and self-expression. One aspect of the actor’s methodical tradition – the openness to suffering and sacrificing oneself in the name of the arts – will be displayed and
Buying brass : A method re-examined
This article is an account of a lecture-performance presentation held in the context of “Contradictions as a Method,” an international Bertolt Brecht symposium that took place in November 2019 at the Academy of Performing Arts in Prague. As three speakers engaged with theatre in different ways, we were inspired by the dialogical structure of Brecht’s play Buying Brass and staged a similarly struct
Southeast Asia’s Roles in Inter-Korean Affairs
Southeast Asia’s significance to the Korean peninsula is growing. South Korea has deepening trade, investment and assistance relationships in the region, while ASEAN’s non-judgmental approach to diplomacy is useful in dealing with Pyongyang. Beyond hosting summits between American and North Korean leaders, Southeast Asia is in a position to mediate North Korea’s greater international engagement an
Beyond Binaries: Southeast Asian Relations with North Korea
The Pahlavis and the Other Side of the Coins
It was with great interest that I read “Political Power of Iranian Hierocracies” by János Jany published in Comparative Civilizations Review. Writing about Iranian history is not an easy task because historical points of view have been highly politicized. Such is particularly the case when discussing the Pahlavi dynasty, particularly its founder, Reza Shah Pahlavi, and his successor, Mohammed Reza
Modelers Modelling Models
Demonstrationstågen har antagit en ny skepnad
Soils, sinks, and smallholder farmers: Examining the benefits of biochar energy transitions in Kenya
Besides reducing fuel demands and indoor air pollution, pyrolytic cooking stoves produce a by-product (biochar) that can improve soil fertility and serve as a sink for carbon sequestration. Most smallholder farmers in Africa depend on wood for fuel, suffer from exposure to smoke and soils in their cultivated farms are deteriorating. Biochar (bio-charcoal) production has potentials to reduce energy
The Game of Tubulins
Members of the tubulin superfamily are GTPases; the activities of GTPases are necessary for life. The members of the tubulin superfamily are the constituents of the microtubules and the γ-tubulin meshwork. Mutations in members of the tubulin superfamily are involved in developmental brain disorders, and tubulin activities are the target for various chemotherapies. The intricate functions (game) of
Lovers of the Rose : Islamic Affect and the Politics of Commemoration in Turkish Museal Display
This chapter explores Hilye-i Şerif, the calligraphic description of the Prophet Muhammad—and its significance in current Turkish politics. With roots in Ottoman literature, art and Prophet devotion, this genre is currently witnessing a striking artistic innovativeness. Under the theme of Aşk-ı Nebi (Love for the Prophet), several public exhibitions have been organised within recent, state-run mevThis chapter explores Turkish museal display as an arena for memory-cultural Islamisation, extending beyond the walls of museums. It probes museums as spaces for exhibiting nationalism, and the burgeoning interest in religion and affect within a new museology. It discusses how Turkish expositions have appropriated aspects of such a new museology in restorative-commemorative expositions of the Otto
Sacred (re)collections : Culture, space and boundary negotiation in Turkish-Islamic memory politics
This article discusses how state-organized, memory-cultural production drawing on religious signifiers contributes to a sacralization of Turkish public memory institutions and public space. This reinforces an Islamic-nationalist imagination of contemporary Turkey. The article explores state-led, disciplinary interventions in museal space (the Sacred Trusts exhibition of relics at Topkapı Palace MuThis article discusses how state-organized, memory-cultural production drawing on religious signifiers contributes to a sacralization of Turkish public memory institutions and public space. This reinforces an Islamic-nationalist imagination of contemporary Turkey. The article explores state-led, disciplinary interventions in museal space (the Sacred Trusts exhibition of relics at Topkapı Palace Mu