Polymorphic genes involved in the conserved molecular signalling of circadian and circannual clocks may play important roles in governing the timing of breeding and dispersal and thereby affect fitness in vertebrates. However, relatively few studies have explored associations between phenological candidate genes and behaviour, and these are somewhat biased towards particular taxonomic groups such

AIMS/HYPOTHESIS: PPARGC1A and PPARGC1B encode transcriptional coactivators that regulate numerous type 2 diabetes-related metabolic processes. Common genetic variation across PPARGC1A/B was characterised by genotyping tagging variants. We then tested associations of these variants with diabetes incidence or change in quantifiable metabolic traits directly or via interactions (with metformin treatm

OBJECTIVE: The aim of this study was to examine the longitudinal impact of blood pressure variations and vascular risk factors on depressive symptoms in the elderly. DESIGN: Longitudinal and cross-sectional cohort study. SETTING: Urban population of elderly men, city of Malmö, Sweden. PARTICIPANTS: A total of 809 randomly included men took part in a prospective cohort study, "Men born in 1914", an

OBJECTIVE: We sought to analyze the prevalence and clinical manifestations of Mycoplasma genitalium infection in a heterogeneous population of women. STUDY DESIGN: The study was designed as a cross-sectional case-control study. Women attending a gynecological outpatient service from 2003 through 2008 were invited to participate. RESULTS: The prevalence of M genitalium was 2.1% and of Chlamydia

OBJECTIVE: Diamond-Blackfan anemia (DBA) is a rare congenital hypoplastic anemia caused by mutations in ribosomal protein (RP) genes. Our aim is to develop gene therapy for DBA patients with mutations in RPS19. We previously demonstrated that RPS19 gene transfer partially corrects erythroid development in vitro. In this study, we asked if RPS19 gene transfer corrects erythroid development in unsor

In order to identify genes associated with primary chemotherapy-resistance, gene expression profiles (GEP) in tumour tissue from 37 patients with de novo diffuse large B-cell lymphoma (DLBCL), stage II-IV, either in continuous complete remission (n = 24) or with progressive disease during primary treatment (n = 13), were examined using spotted 55K oligonucleotide arrays. Immunohistochemistry was u

Objective:To examine the impact of non-response to self-reported body weight and height in health questionnaires for the estimation of obesity prevalence.Methods and Procedures:A cross-sectional population-based health survey in the community ofVara with 16,009 residents (in year 2002) in South-western Sweden. Participants randomly selected in strata by sex and age among residents being 30-74 year

Similarities between gambling disorder and substance use disorders have been extensively described. To date, however, few studies using large clinical samples have been carried out that reliably assess the relationship between different levels of alcohol consumption and gambling disorders. The present study aimed to assess the impact of baseline alcohol consumption levels on the clinical profile i

Several disperse dyes (DDs) are still considered to be the most important allergens in textile dermatitis, but there are sparse data about their current use in textiles. The aim of this review was to evaluate published studies and reports on contact allergy to DDs published in PubMed during the last 22 years (1990-2012). Prevalence data are provided by study and by dye, as well as by the described

The question as to whether Jesus preached repentance has been discussed in historical Jesus research over the past twenty years, apparently without any scholarly consensus being at hand. This article seeks to eliminate some unnecessary confusion from the debate by investigating early Jewish conceptions of repentance and suggesting that a distinction should be maintained between moral and ritual re

Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by selective degeneration of the dopamine producing neurons in the substantia nigra. There is currently no clinically applicable therapy for treating or preventing Parkinsonian neurodegeneration. Great effort is put behind the development of novel therapeutic approaches that aim to alter the natural progression of the dise

Background: Traditionally, contact allergy to aluminium has been established by patch testing with aluminium chloride hexahydrate in petrolatum at 2.0% and an empty Finn Chamber®. Objectives: The aim of this study was to investigate different aluminium test preparations regarding an optimal compound and an optimal test concentration. Methods. Six different aluminium compounds and an empty Finn C

Thromboembolism (TE) is a major toxicity in children with acute lymphoblastic leukemia (ALL) and may have a negative impact on ALL treatment.

This study aimed to capture and operationalize the concept of participation among people who are very old (age > 80) and to investigate whether and how aspects of housing and neighborhood environments relate to participation in very old age. Two dimensions of participation--performance-oriented participation and togetherness-oriented participation---emerged from an earlier qualitative study and we