Tissue Factor Pathway Inhibitor (TFPI) is a naturally occurring inhibitor of the TF-FVIIa induced coagulation in the presence of FXa. Recombinant two domain TFPI, where Asn 117 on the FXa-inhibitory domain was exchanged to a Gln yielding non-glycosylated TFPI (117QTFPI1-161), was evaluated regarding pharmacokinetics and delayed antithrombotic potential in the rabbit. Pharmacokinetic study 117QTFPI

Background: Childhood obesity is a major clinical and economic health concern. Alongside the clinical understanding of obesity, there is a growing interest in designing and implementing interventions that are worth their money given the scarce resources in the health care sector. This study is one of the first efforts to provide evidence by assessing the effects and costs of a population-based pri

BACKGROUND: The release of neuron-specific astroglial S-100 protein to the cerebrospinal fluid is a marker of cerebral damage. The aim of this study was to determine the pattern of release of S-100 protein to serum after pediatric cardiac operations and extracorporeal circulation.METHODS: Sequential blood samples from 97 children (up to 16 years) were taken after induction of anesthesia, immediate

Background: As much as 40–50% of children are expected to sustain fractures during growth. A childhood fracture is alsoassociated with high risk of fractures in adult life. Previous research has shown that fracture incidence has not been stable andsome studies suggest that this has also continued during recent decades.Aims: The aim of this thesis was therefore to describe fracture epidemiology and

Sustainable business model innovation is an emerging topic, but only few tools are currently available to assist companies in sustainable business modelling. This paper works towards closing this gap by bringing together ‘design thinking’ and ‘sustainable business model innovation’ to refine the creative process of developing sustainable value propositions and improve the overall business modellin

GaSb nanostructures integrated on Si substrates are of high interest for p-type transistors and mid-IR photodetectors. Here, we investigate the metalorganic chemical vapor deposition and properties of GaSb nanostructures monolithically integrated onto silicon-on-insulator wafers using template-assisted selective epitaxy. A high degree of morphological control allows for GaSb nanostructures with cr

Little is known about how gendered understandings of patients can inform professionals’ discretionary actions and decisions to include or exclude in clinical practice. Using Connell's poststructuralist perspectives on gender as an analytic framework, this article aims to investigate how professionals’ articulations of depression are framed by signs of masculinity and femininity, and how these artiLittle is known about how gendered understandings of patients can inform professionals’ discretionary actions and decisions to include or exclude in clinical practice. Using Connell's poststructuralist perspectives on gender as an analytic framework, this article aims to investigate how professionals’ articulations of depression are framed by signs of masculinity and femininity, and how these arti

Members of the orchid genus Nigritella are widespread in European mountains, but species circumscriptions and evolutionary patterns in the genus are subjects to conflicting opinions. We analyzed a representative material of Nigritella for differentiation at nuclear and plastid marker loci. In agreement with predictions from embryological studies, diploid members of Nigritella are sexual and mostly

Glucose-stimulated insulin secretion is biphasic, with a rapid first phase and a slowly developing sustained second phase; both are disturbed in type 2 diabetes (T2D). Biphasic secretion results from vastly different release probabilities of individual insulin granules, but the morphological and molecular basis for this is unclear. Here, we show that human insulin secretion and exocytosis critical

In this study, we have used the coarse-grained model developed for the intrinsically disordered saliva protein (IDP) Histatin 5, on an experimental selection of monomeric IDPs, and we show that the model is generally applicable when electrostatic interactions dominate the intra-molecular interactions. Experimental and theoretically calculated small-angle X-ray scattering data are presented in the

Germany has one of the most ambitious climate policy goals worldwide, having pledged to reduce national emissions by 40% by 2020, and 80–95% by 2050 (base year: 1990). 2015 data suggests that progress on decarbonisation has slowed, also because emissions from the transport sector have grown. Road transport, which is contributing 20.5% to Germany's CO2 emissions, has become a major obstacle to achi

This paper describes the adaptation of the laser-induced fluorescence measurement technique for the investigation of the primary breakup of modern diesel and gasoline direct injection sprays. To investigate the primary breakup, a microscopic technique is required, and with the help of special tracer dyes, a high fluorescence signal can be achieved in the visible range of the electromagnetic spectr

The arrival of the Digital Age added a new way to preserve memories of war and conflict. These developments beg deeper reflection on the role of cyberspace and how memories of conflict have become publicly and collectively owned, shared and mediated in the digital space. Cyberspace offers a context for the deposit of digital memorials for victims and casualties of war from any adversary in a confl

Human activities and climate change affect hydrological and sedimentological characteristics within catchments. For arid and semiarid areas this induces direct negative economic and environmental consequences on society. In fact, stability in the rainfall regime and less siltation trapped in reservoirs mean more water for irrigation, water supply, and better flood control. This is especially impor

In 66 CE, Marcia Servilia (PIR2 S 606) was summoned before the Senate to answer the accusation that she had paid magicians to conduct rites on her father’s behalf (Tac. Ann. 16.30–3; Dio Cass. 62.26.3; Marshall 1990, 363, case no. 24; Pollard 2014). Servilia and her father, who was accused of maiestas, made pleas before the Senate on each other’s behalf and in Tacitus’ narrative her illegal action

Over the last several decades the hydrologically sensitive Boreal Plains ecoregion of Western Canada has experienced significant warming and drying. To better predict implications of land cover changes on evapotranspiration (ET) and future water resources in this region, high resolution light detection and ranging and energy balance data are used here to spatially parameterize the Penman-Monteith

BACKGROUND: Comparable estimates of health spending are crucial for the assessment of health systems and to optimally deploy health resources. The methods used to track health spending continue to evolve, but little is known about the distribution of spending across diseases. We developed improved estimates of health spending by source, including development assistance for health, and, for the fir

Background: The frequency of allergic contact dermatitis caused by (meth)acrylates is increasing worldwide, and isobornyl acrylate (IBOA) has been identified as a culprit sensitizer in FreeStyle Libre, a medical device used by diabetic patients. Objectives: To report on 4 patients sensitized to IBOA contained in OmniPod, a new, tubeless insulin pump, and to describe the clinical and chemical analy