Electrospun Nanofibrous Polycaprolactone Scaffold for High Throughput Screening of Anti-cancer Drugs in 96-well Plates
Cell culturing is most commonly performed in conventional 96-well plates where cells are grown in a monolayer, on two-dimensional (2D) surfaces. However, a tumor grows in three dimensions (3D) in the human body and exhibits complex features that cannot be translated onto a 2D system. Likewise, an anti-cancer drug that has been pre-clinically tested in a 2D system is likely to fail clinical trials.
