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Patients with alkaptonuria lack homogentisate 1,2-dioxygenase leading to retention of homogentistic acid (HGA) in body fluids and eventually to tissue deposition of oxidation products, giving rise to the clinical picture of ochronosis. Ascorbic acid is a known inhibitor of the enzyme which catalyses the oxidation of homogentisic acid (HGA) to the polymer with affinity for collagen and was used in

Twenty-one of 25 consecutive primary fibromyalgia or fibrositis patients, identified during a 5-year period in a tertiary care day-ward for pain syndromes, were re-examined. Fifteen fulfilled criteria for fibromyalgia but unexpectedly, all cases had either psychiatric disturbance or thyroid dysfunction. Of the four patients not seen at follow-up, two had developed neurological diseases, another rh

For high-resolution massive MIMO and very large antenna arrays, wireless channel models have to scrutinize the detailed space features of the surrounding environment. Existing models such as WINNER and 3GPP are not appropriate for validating and evaluating new concepts for 4G/5G as they do not consider the spatial characteristics of the real environment. The simplified 3D shapes of simulated objec

Recent studies show that real-time precise user localization enables to deliver accurate beamforming in MIMO systems without the need for channel estimation. This paper presents new solutions for accurate user localization in massive MIMO LTE systems. A key novelty of the developed schemes is the ability to locate users during LTE's random access channel synchronization procedure before they are c

This textbook advocates patients’ empowerment for improving health outcomes and health system performance. It emphasizes the important implications of improving communication between patient and health professionals and the adherence to treatment regimens.Based on research including theories of Stages of Change and Decision Balance, and by incorporating examples from daily clinical practice, this This textbook advocates patients’ empowerment for improving health outcomes and health system performance. It emphasizes the important implications of improving communication between patient and health professionals and the adherence to treatment regimens. Based on research including theories of Stages of Change and Decision Balance, and by incorporating examples from daily clinical practice, this

Abstract Abiotic environmental factors play a fundamental role in determining the distribution, abundance, and adaptive diversification of species. Empowered by new technologies enabling rapid and increasingly accurate examination of genomic variation in populations, researchers may gain new insights into the genomic background of adaptive radiation and stress resistance. We investigated genomic v

In species with chromosomal sex determination, X chromosomes are predicted to evolve faster than autosomes becauseof positive selection on recessive alleles or weak purifying selection. We investigated X chromosome evolution inStegodyphus spiders that differ in mating system, sex ratio, and population dynamics. We assigned scaffolds to Xchromosomes and autosomes using a novel method based on flow In species with chromosomal sex determination, X chromosomes are predicted to evolve faster than autosomes because of positive selection on recessive alleles or weak purifying selection. We investigated X chromosome evolution in Stegodyphus spiders that differ in mating system, sex ratio, and population dynamics. We assigned scaffolds to X chromosomes and autosomes using a novel method based on fl

While more and more antennas are integrated into a single mobile user equipment to increase communication quality and throughput, the number of antennas used for transmission is commonly restricted due to the concerns on hardware complexity and energy consumption, making it impossible to achieve the maximum channel capacity. This paper investigates the problem of reconstructing the full downlink c

The past few years have witnessed dramatic growth in the number of wirelessly connected devices, which will continue to increase in the future. Following this trend, the capacity of the wireless networks has been enhanced to provide high-quality service to tens of billions of devices. At the same time, in response to the network enhancement, each device unashamedly requests more and more throughpu

In the RB experiment at FAIR, charged particles with energies up to 600 MeV and forward boosted -rays with energies up to 20 MeV need to be detected in scattering experiments. Calorimeters for nuclear physics experiments of this kind, using relativistic radioactive ion beams, require high energy resolution and high efficiency for simultaneous detection of strongly Doppler shifted -rays and high-en