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COPD and the risk of tuberculosis--a population-based cohort study.

BACKGROUND: Both chronic obstructive pulmonary disease (COPD) and tuberculosis (TB) primarily affect the lungs and are major causes of morbidity and mortality worldwide. COPD and TB have common risk factors such as smoking, low socioeconomic status and dysregulation of host defence functions. COPD is a prevalent co-morbid condition, especially in elderly with TB but in contrast to other diseases k

The Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes: The EPIC-InterAct Study.

Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores in T2D development. However, ferritin is influenced by factors other than iron stores, which is less the case for other biomarkers of iron metabolism. We investigate associations of ferritin, transferrin saturation (TSAT), serum iron, and transferrin with T2D incidence to cla

Pain, fatigue and hand function closely correlated to work ability and employment status in systemic sclerosis.

Objective: To identify factors, individual and work related, influencing work ability, and to assess the association between work ability and employment status, activities of daily life (ADLs) and quality of life in patients with SSc. Methods: Fifty-seven consecutive patients (53 females/4 males) with SSc (47 lcSSc/10 dcSSc) were included. Median age was 58 [interquartile range (IQR) 47-62] year

Hypothalamic and Neuroendocrine Changes in Huntington's Disease.

Huntington's disease (HD) is a fatal hereditary neurodegenerative disorder without satisfactory treatments nor a cure. It is caused by a CAG repeat expansion in the huntingtin gene. The clinical symptoms involve motor-, cognitive- and psychiatric disturbances. Recent studies have shown that non-motor symptoms and signs, such as mood changes, sleep disturbances and metabolic alterations often occur

Lund Virtual Medical Journal Makes Self-Archiving Attractive and Easy for Authors

This article highlights the importance of communication and collaboration with units outside the library to make self-archiving attractive to authors. The monthly electronic publication, Lund Virtual Medical Journal (LVMJ), published by the Department of Strategic Communication of the Faculty of Medicine at Lund University, started as a response to the need to increase the visibility of ongoing re

Spectral statistics and the fine structure of the electric pygmy dipole resonance in N=82 nuclei

We study the statistical properties of the electric pygmy dipole resonance in four different isotones with neutron number N = 82. These nuclei are Ba-138(56), Ce-140(58), Nd-142(60), (144)(62)sm. The data set comprises levels with spin and parity J(pi) = 1(-) and their ground state B(E1) transition strengths. The statistics are found to be "mixed", i.e., in between the predictions of random matrix

Socker triggar våra belöningssystem. Sött frisätter opiater som sätter fart på sötsuget - insulin kan dämpa det

Intag av söta livsmedel har ökat i Sverige och övriga västvärlden. Typ av söta livsmedel har också ändrat karaktär; sött finns idag främst som dryck – läskkonsumtionen står i särklass över andra söta drycker. Aptitreglering för socker har beskrivits i djurmodeller, där det visats att opiatfrisättning triggar sockerintag i en uppåtgående spiral. Troligen gäller samma för människa. Sött frisätter opThe consumption of sweet food has increased in Sweden, as in other Western countries. The type of food item has changed. The sweet is dominated by soft drinks. Appetite regulation for sucrose has been described in experimental animal models. It has been found that opioids stimulate appetite for sucrose. At the same time sucrose releases endogenous opioids so that a triggering of sucrose consumptio

Interactions between Streptococcus pyogenes and the human immune defence

Streptococcus pyogenes is an important human pathogen frequently colonizing the throat and skin of humans. To facilitate colonization and spread and to avoid the host immune defence, streptococci are endowed with a variety of virulence factors, two of which are investigated in this thesis namely streptolysin O (SLO) and M protein. SLO is a secreted cytolysin that forms pores in eukaryotic membran

Glypicans.

A family of lipid-linked heparan sulfate (HS) proteoglycans, later named glypicans, were identified some 15 years ago. The discoveries that mutations in genes involved in glypican assembly cause developmental defects have brought them into focus. Glypicans have a characteristic pattern of 14 conserved cysteine residues. There are also two–three attachment sites for HS side-chains near the membrane