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Accumulating evidence suggests altered energy metabolism as a key feature in Huntington's disease (HD) pathology. Hyper-catabolism, including weight loss and muscle atrophy, is seen in HD patients and HD mouse models. Metabolic hormones are key players, not only in energy metabolism, but also in neurodegenerative processes. Ghrelin, a gut peptide-hormone, plays an important role in regulating ener
Objective. Resistance to activated protein C (APC resistance), caused by a single point mutation in the factor V gene (FV:R506Q), is a major risk factor for venous thrombosis. As the significance of this mutation among unselected outpatients with deep-vein thrombosis (DVT) is not established, we have studied its prevalence among consecutive outpatients attending the emergency room due to a clinica
Introduction: Exposure to allergens plays a role in the development of atopic sensitization and influencesallergic phenotype. The effects of exposure to relevant allergens both from the indoor and outdoorenvironment are complex. Immigrant children and their families are exposed to new spectra of seasonaland perennial allergens, and often new lifestyle factors, such as diet, and living conditions.
The non-receptor tyrosine kinase LCK belongs to the SRC family of kinases. SRC family kinases are proto-oncogenes that have long been known to play key roles in cell proliferation, motility, morphology and survival. Here we show that LCK regulates the function of the type III receptor tyrosine kinase FLT3 in murine pro-B cells. We observed that expression of LCK significantly enhances the colony f
Single-family houses (SFHs) constructed between 1961 and 1980 account for approximately one-third of the total energy use, 31 TWh, for space heating and domestic hot water in Swedish SFHs. These are responsible for about 40 percent of the total energy use in all buildings. There are roughly 715,000 houses from this period and they are largely homogeneous in technical terms, with low levels of ther
There is an unmet need to reliably and non-invasively monitor disease progression in preclinical Huntington's disease (HD) models. As a marker of axonal damage, neurofilament light chain (NfL) has been suggested a marker for neurodegeneration. NfL concentrations in blood and CSF were recently shown to have prognostic value for clinical HD progression and brain atrophy. We therefore hypothesized th
Bouncing on a trampoline lets the jumper experience the interplay between weightlessness and large forces on the body, as the motion changes between free fall and large acceleration in contact with the trampoline bed. In this work, several groups of students were asked to draw graphs of elevation, velocity and acceleration as a function of time, for two full jumps of the 2012 Olympic gold medal tr
Aquaporins are tetrameric membrane-bound channels that facilitate transport of water and other small solutes across cell membranes. In eukaryotes, they are frequently regulated by gating or trafficking, allowing for the cell to control membrane permeability in a specific manner. Protein-protein interactions play crucial roles in both regulatory processes and also mediate alternative functions such
Free fall is commonly discussed as an example of the equivalence principle, in the context of a homogeneous gravitational field, which is a reasonable approximation for small test masses falling moderate distances. Newton's law of gravity provides a generalisation to larger distances, and also brings in an inhomogeneity in the gravitational field. In addition, Newton's third law of action and reac
Aristokratiska gårdsanläggningar med residensbyggnad och kyrka var vanligt förekommande på den medeltida landsbygden. Företeelsen tycks ha existerat också i urbana miljöer. De icke-regala lundensiska träkyrkorna kan ses som privatkyrkor indikerande på aristokratiska stadsgårdar. Dessa ersattes senare med stenkyrkor vilka via patronatskap fortsatt var knutna till frälsets urbana gårdar, en rumslig
A third of Sweden’s two million single-family houses were built in the period 1961-1980, and many of them are in need of renovation. Energy use in these houses is high, and they are fairly homogeneous in technical terms. A previous study of four reference houses showed that final energy use could be reduced in theory by approximately 65-75 % after renovation, by implementing conventional passive h
This paper evaluates whether a net-zero energy building (NZEB) can be attained by implementing on-site renewable electricity production when renovating to Passive House level. The assessment is based on the Swedish single-family housing stock constructed between 1961 and 1980, using two case study houses and three locations. Specific conditions of the houses, such as the type of heat generation an
Our perception of time varies considerably from moment to moment, but how this variability relates to endogenous fluctuations in attentional states has been neglected. Here, we tested the hypothesis that perceptual decoupling during spontaneous mind wandering episodes distorts interval timing. In two studies with different visual subsecond interval timing paradigms, participants judged their atten
We review the history of Quaternary pollen analysis from 1916 to the present-day, with particular emphasis on methodological and conceptual developments and on the early pioneers of the subject. The history is divided into three phases—the pioneer phase 1916–1950, the building phase 1951–1973, and the mature phase 1974–present-day. We also explore relevant studies prior to Lennart von Post’s semin
Rising carbon dioxide (CO2) concentrations and temperatures are expected to stimulate plant productivity and ecosystem C sequestration, but these effects require a concurrent increase in N availability for plants. Plants might indirectly promote N availability as they release organic C into the soil (e.g., by root exudation) that can increase microbial soil organic matter (SOM) decomposition (“pri
Late Sandbian to early Katian δ13Ccarb chemostratigraphy has in Norway been described in only two previous reports that dealt with two geographically rather widely separated areas, namely the Oslo-Asker district and the Nes-Hamar district. No data have been available from the Ordovician outcrop areas between these districts that could help clarify the partly unclear regional stratigraphic relation
The gold standard for an empirical science is the replicability of its research results. But the estimated average replicability rate of key-effects that top-tier psychology journals report falls between 36 and 39% (objective vs. subjective rate; Open Science Collaboration, 2015). So the standard mode of applying null-hypothesis significance testing (NHST) fails to adequately separate stable from
The Harmonized Parabolic Synthesis methodology is a further development of the Parabolic Synthesis methodology for approximation of unary functions such as trigonometric functions, logarithms and the square root with moderate accuracy for ASIC implementation. These functions are extensively used in computer graphics, communication systems and many other application areas. For these high-speed appl
Today, the majority of control applications in embedded systems, e.g., in the automotive domain, are implemented as software tasks on shared platforms. Ignoring implementation impacts during the design of embedded control systems results in complex timing behaviors that may lead to poor performance and, in the worst case, instability of control applications. This article presents a methodology for
