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Convergence analysis of iterative learning control using pseudospectra

Iterative learning control (ILC) is an approach to improve the performance of a system that repeats the sameoperation. In this paper, we apply the theory of pseudospectra to transient analysis of ILC. The focus of thispaper is on frequency-domain analysis of filter-based ILC. Moreover, the effect of finite trial length on thetransient growth is discussed.

Effects of feed composition, protein denaturation and storage of milk serum protein/lactose powders on lactosylation

During whey powder production, the feed is subjected to several heat treatments which can cause lactosylation of proteins. In this study, lactosylation of whey proteins was evaluated in spray-dried powders before and after storage by varying the native protein fraction as well as the serum protein/lactose ratio in the powders. The lactosylation of native α-lactalbumin and β-lactoglobulin in the po

Liquid fiducial marker applicability in proton therapy of locally advanced lung cancer

Background and purpose We investigated the clinical applicability of a novel liquid fiducial marker (LFM) for image-guided pencil beam scanned (PBS) proton therapy (PBSPT) of locally advanced lung cancer (LALC). Materials and methods The relative proton stopping power (RSP) of the LFM was calculated and measured. Dose perturbations of the LFM and three solid markers, in a phantom, were measured. P

Many-body calculations of two-photon, two color matrix elements for attosecond delays

Interferometric measurements based on the combination of extreme ultraviolet (XUV) attosecond pulse trains with weak infrared laser fields, have been successfully used to study time-resolved and recently angle-resolved photoemission in various atomic systems. These measurements rely on quantum interference between electron wavepackets created by absorption of XUV radiation, with further absorption

Time-resolved dynamics of thiophene dication - Probing parent molecule survival times and multi-step dissociation processes of cyclic molecules by free-electron-laser experiments combined with theoretical simulations

Thiophene is a cyclic molecule that becomes unstable as a molecular dication. We followed the multi-step dissociation dynamics triggered by soft x-ray FEL pulses from SACLA, core-ionizing the S 2p orbital and creating parent dications by the Auger decay. The time-evolution was probed by optical laser pulsesthat reveal the survival lifetime of the parent dication and the build-up of fragmentation p

Use of cardiovascular drugs and risk of incident heart failure in patients with atrial fibrillation

Congestive heart failure (CHF) is the most important cause of death in patients with atrial fibrillation (AF). We aimed to study the association between cardiovascular drugs in AF patients and incident CHF. The study population included all adults (n = 120 756) aged ≥45 years diagnosed with AF in Sweden diagnosed for the period 1998-2006. Outcome was incident congestive heart failure (follow-up 20

RIFM fragrance ingredient safety assessment, 1-(2-methylprop-2-enoloxy)-2,2,4-trimethylpentan-3-ol, CAS Registry Number 526218-21-3

The existing information supports the use of this material as described in this safety assessment. 1-(2-Methylprop-2-enoloxy)-2,2,4-trimethylpentan-3-ol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 1-(2-methylprop-2-enoloxy)-2,2,4-trimethylpen

p53 is associated with high-risk and pinpoints TP53 missense mutations in mantle cell lymphoma

Survival for patients diagnosed with mantle cell lymphoma (MCL) has improved drastically in recent years. However, patients carrying mutations in tumour protein p53 (TP53) do not benefit from modern chemotherapy-based treatments and have poor prognosis. Thus, there is a clinical need to identify missense mutations through routine analysis to enable patient stratification. Sequencing is not widely

Early infantile epileptic encephalopathy due to biallelic pathogenic variants in PIGQ : Report of seven new subjects and review of the literature

We investigated seven children from six families to expand the phenotypic spectrum associated with an early infantile epileptic encephalopathy caused by biallelic pathogenic variants in the phosphatidylinositol glycan anchor biosynthesis class Q (PIGQ) gene. The affected children were all identified by clinical or research exome sequencing. Clinical data, including EEGs and MRIs, was comprehensive

Effects of feed composition, protein denaturation and storage of milk serum protein/lactose powders on rehydration properties

Whey powder rehydration is expected to be closely linked to both denaturation and lactosylation of the proteins. This study investigated the relation between the forced imbibition rate of spray-dried milk serum protein/lactose powders and the particle morphology and how it is related to the insoluble and lactosylated protein fraction, respectively. Despite extensive variation in protein denaturati

Development of early calcareous nannoplankton in the late Triassic (Northern Calcareous Alps, Austria)

Calcareous nannofossils are considered to be the most productive calcifying organisms, but the impact of their emergence on the chemistry of the ocean in the Late Triassic is not understood yet. Evolutionary details of this bio-event are missing due to the scarcity of well-preserved outcrops worldwide. The current study focuses on the calcareous nannofossil assemblage of the middle Norian to lower

Cholesterol lowering with EVOLocumab to prevent cardiac allograft Vasculopathy in De-novo heart transplant recipients : Design of the randomized controlled EVOLVD trial

Background: Cardiac allograft vasculopathy (CAV) is characterized by diffuse thickening of the arterial intima. Statins reduce the incidence of CAV, but despite the use of statins, CAV remains one of the leading causes of long-term death after heart transplant. Inhibitors of proprotein convertase subtilisin-kexin type 9 (PCSK9) substantially reduce cholesterol levels but have not been tested in he

Neural correlates of task-related refixation behavior

Eye movement research has shown that attention shifts from the currently fixated location to the next before a saccade is executed. We investigated whether the cost of the attention shift depends on higher-order processing at the time of fixation, in particular on visual working memory load differences between fixations and refixations on task-relevant items. The attention shift is reflected in EE

Wild bees and hoverflies respond differently to urbanisation, human population density and urban form

While urbanisation contributes to global biodiversity declines, flower-rich urban habitats may provide beneficial pollinator habitats. We investigated the potential of urban residential areas to contribute to pollinator diversity by analysing wild bee and hoverfly species richness and composition of species assemblages of summer-active species, sampled in 53 gardens across urban and rural landscap

Realizing the 2030 Agenda for sustainable development–engaging national parliaments?

This article examines the role of national parliaments in policy processes related to the realization of the 2030 Agenda for sustainable development, adopted in the UN General Assembly in 2015. We outline three main roles of parliaments in the case of national policy-making based on intergovernmental agreements: legislative and policy approval, citizen representation, and accountability. The cases

Individual Driving Behaviour in Wildfire Smoke

This work presents the results of a virtual reality (VR) experiment aiming at investigating how individual driving behaviour is affected by the presence of wildfire smoke. The experiment included a driving simulation task to study the chosen driving speed at different smoke densities and the lateral position of the driven car on the road cross section. During the VR experiment, participants were p

Tracking Rats in Operant Conditioning Chambers Using a Versatile Homemade Video Camera and DeepLabCut

Operant conditioning chambers are used to perform a wide range of behavioral tests in the field of neuroscience. The recorded data is typically based on the triggering of lever and nose-poke sensors present inside the chambers. While this provides a detailed view of when and how animals perform certain responses, it cannot be used to evaluate behaviors that do not trigger any sensors. As such, ass