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Breast Tomosynthesis or Digital Mammography for Breast Cancer Screening?

Screening mammography plays a key role in the early detection of breast cancer, however, estimates of sensitivities (48-88%) and specificities (82-98%) suggest that the diagnostic accuracy can be improved (1, 2, 3). Breast tomosynthesis (BT) is a 3D technique that is expected to improve breast cancer detection compared to screen-film and digital mammography DM). This work presents two clinical obs

Haemophilus influenzae Protein E Binds to the Extracellular Matrix by Concurrently Interacting With Laminin and Vitronectin

Nontypeable Haemophilus influenzae (NTHi) causes otitis media and is commonly found in patients with chronic obstructive pulmonary disease (COPD). Adhesins are important for bacterial attachment and colonization. Protein E (PE) is a recently characterized ubiquitous 16 kDa adhesin with vitronectin-binding capacity that results in increased survival in serum. In addition to PE, NTHi utilizes Haemop

Characterization of the Influence of Vildagliptin on Model-Assessed {beta}-Cell Function in Patients with Type 2 Diabetes and Mild Hyperglycemia.

Objective: This study was conducted to characterize the effects of vildagliptin on beta-cell function in patients with type 2 diabetes and mild hyperglycemia. Design: A 52-wk double-blind, randomized, parallel-group study comparing vildagliptin (50 mg qd) and placebo was conducted in 306 patients with mild hyperglycemia (A1C = 6.2-7.5%). Plasma glucose and C-peptide levels were measured during sta

Sarmatia-Volgo-Uralia junction zone: Isotopic-geochronologic characteristic of supracrustal rocks and granitoids

The geochronologic (U-Pb isotopic system of zircons) and isotopic-geochemical (Sm-Nd isotopic system of the bulk rock) studies were performed along the profile extending from the eastern Sarmatia (in the west) to the Middle Volga megablock of Volgo-Uralia (in the east), i.e., across the entire junction zone for dating the integration of Sarmatia and Volgo-Uralia, representing two segments of the E

Utveckling av en metod, Care Optimizer, för mätning av vårdbehov och resursanvändning inom kommunal äldreomsorg

Föreliggande avhandling består av fyra studier där det övergripande syftet med studierna var att utveckla ett mätinstrument för att bedöma vårdbehov och tidsåtgång relaterat till vilka personella resurser som krävs för att tillgodose aktuellt vårdbehov hos äldre boende på särskilda boenden inom kommunal äldreomsorg. Instrumentet har fått namnet Time in Care (TiC) och är uppdelat i två delar: Time

It's a Long Way from Helsingborg to Porto Alegre: A Case Study in Deliberative Democracy in Late Modernity

Since the 1990’s representative democracy has been challenged by a deliberative turn in political philosophy, reaching even into the practices of established political institutions. In Sweden, the Municipality of Helsingborg, inspired by deliberative ideals, established civic committees as a way to deal with changing patterns of civic political behavior in late modernity. One reason for this is th

Theory development in humanitarian logistics: a framework and three cases

Purpose – There is a need for theory development within the field of humanitarian logistics to understand logistics needs in different stages of a crisis and how to meet these. This paper aims to discuss three dimensions identified in logistics and organization theories and how they relate to three different cases of humanitarian logistics operations – the regional concept of the International Fed

Biocompatibility of mannan nanogel-safe interaction with plasma proteins

Background: Self-assembled mannan nanogels are designed to provide a therapeutic or vaccine delivery platform based on the bioactive properties of mannan to target mannose receptor expressed on the surface of antigen-presenting cells, combined with the performance of nanogels as carriers of biologically active agents. Methods: Proteins in the corona around mannan nanogel formed in human plasma wer

Effects of surfactin on membrane models displaying lipid phase separation

Surfactin, a bacterial amphiphilic lipopeptide is attracting more and more attention in view of its bioactive properties which are in relation with its ability to interact with lipids of biological membranes. In this work, we investigated the effect of surfactin on membrane structure using model of membranes, vesicles as well as supported bilayers, presenting coexistence of fluid-disordered (DOPC)

Predators and predation rates of Skylark Alauda arvensis and Woodlark Lullula arborea nests in a semi-natural area in The Netherlands

Predation is a major cause of breeding failure in bird species with open nests. Although many studies have investigated nest predation rates, direct identification of nest predators is sporadic, especially in (semi-)natural habitats. We quantified nest success and identified nest predators in a population of Skylarks Alauda arvensis and Woodlarks Lullula arborea breeding in a protected semi-natura

Advancing Sustainable Urban Transformation

Despite increased awareness of the urgency to respond to climate change and to promote sustainable development, there are few powerful initiatives that are decisively shifting urban development in a sustainable, resilient and low-carbon direction. This Special Volume of the Journal of Cleaner Production explores sustainable urban transformation focusing on structural transformation processes – mul

Modeling and Control of Stiff Robots for Flexible Manufacturing

Popular Abstract in Swedish Made in China - På hur många av dina barns leksaker står det? Produktionen inom många sektorer flyttas från Europa till länder där arbetskraften är billigare. Forskningen i avhandlingen "Modeling and Control of Stiff Robots for Flexible Manufacturing" ska hjälpa europeiska småföretag att bli mer konkurrenskraftiga och samtidigt underlätta för arbetarna. Högt ljud frånTo survive on a global market, small and medium size enterprises (SMEs) require affordable and competitive industrial automation for high quality flexible manufacturing. This thesis contributes to the development of robot concepts that fit the needs of SMEs. A major part of the thesis deals with the modeling of the three degree-of-freedom (DOF) Gantry-Tau parallel kinematic robot, which has the po

A comprehensive ovine model of blood transfusion

Background The growing awareness of transfusion-associated morbidity and mortality necessitates investigations into the underlying mechanisms. Small animals have been the dominant transfusion model but have associated limitations. This study aimed to develop a comprehensive large animal (ovine) model of transfusion encompassing: blood collection, processing and storage, compatibility testing right

Benchmark simulation models, quo vadis?

As the work of the IWA Task Group on Benchmarking of Control Strategies for wastewater treatment plants (WWTPs) is coming to an end, it is essential to disseminate the knowledge gained. For this reason, all authors of the IWA Scientific and Technical Report on benchmarking have come together to provide their insights, highlighting areas where knowledge may still be deficient and where new opportun