1. In the rat hepatic artery, the SK(Ca) inhibitors UCL 1684 (300 nM) completely blocked, and scyllatoxin (1 μM) and d-tubocurarine (100 μM) partially inhibited EDHF relaxations when each of them was combined with charybdotoxin (300 nM). 2. The IK(Ca) inhibitors clotrimazole (3 μM) and 2-chlorophenyl-bisphenyl-methanol (3 μM) strongly depressed EDHF relaxations when each of them was combined with

Nitric oxide (NO)‐independent pathways contributing to acetylcholine (ACh)‐induced relaxation were examined in the rat isolated hepatic artery and aorta at low and high levels of precontraction induced by phenylephrine (PhE). In the hepatic artery, the ACh‐induced relaxation was unaffected by the NO synthase inhibitors Nw‐nitro‐L‐arginine (L‐NOARG, 0.3 mM) and Nω‐nitro‐L‐arginine methyl ester (0.1

The rat hepatic artery responds to acetylcholine (ACh) with an endothelium‐dependent relaxation, which is unaffected by nitric oxide (NO) synthase and cyclooxygenase inhibition. The purpose of this study was to investigate whether the NO‐independent relaxation is caused by hyperpolarization of the smooth muscle cells. In vessels with endothelium ACh induced a hyperpolarization in the presence of 0

1. 1. The effects of progresterone, corticosterone 21-acetate, chlormadinone acetate, dehydroepi-androsterone 3-sulfate and lysophosphatidylcholine were tested on 86Rb-uptake, 3H-5-HT-uptake, ADP-induced aggregation and 5-HT-induced shape change in human platelets. Ouabain and digoxin were used for reference. 2. 2. Ouabain and digoxin 10-5 M inhibited 86Rb-uptake by more than 85%, and chlormadinon

A review of a two-hander Romeo and Juliet plus a Shakespeare mash-up, both in Lund.A review of a two-hander Romeo and Juliet plus a Shakespeare mash-up, both in Lund.

A review of the first in-house English-speaking production of Hamlet at Elsinore Castle.

Within barely a year, two school shootings shook Finland. The school shootings shocked Finnish society, forcing media, academics and experts, police and politicians alike to search for reasons behind the violent incidents. Focusing their analysis on the two main Finnish newspapers, Helsingin Sanomat and Hufvudstadsbladet, authoritative sources of information for Finland's two language communities,

PurposeThis paper aims to consolidate the knowledge in last mile logistics research, analyze the development of the research area, and provide future research directions.Design/methodology/approachA systematic literature review identified 154 peer-reviewed journal publications from 2001 to 2019 in 83 scientific journals contributing to last mile logistics research.FindingsMain topics in last mile

Spectral induced polarization (SIP) measurements have been demonstrated to correlate with important parame-ters in hydrogeological and environmental investigations. Although SIP measurements were often collected in thefrequency domain (FDIP), recent developments have demonstrated the capabilities to solve for the frequency-de-pendence of the complex conductivity through measurements collected in t

Aim of the MIRACHL project is the characterisation and monitoring of in-situ remediation of chlorinated hydrocarbon contamination using an interdisciplinary approach. Therefore, geophysical methods, as e.g. DCIP are used to investigate the remediation process.To interpret these geophysical field IP data, lab investigations with different kinds of bacteria are necessary to assess the sensitivity of

The aim of the MIRACHL project is the characterisation and monitoring of insituremediation of chlorinated hydrocarbon contamination using an interdisciplinary approach and geophysical methods, such as DCIP (direct current induced polarisation) to investigate the remediation process.To interpret these geophysical field IP data, lab investigations with different kinds of bacteria are necessary to as

There is a need for novel strategies to initiate cancer cell death. One approach is the use of Smac mimetics, which antagonize inhibitor of apoptosis proteins (IAPs). Recent studies have shown that combinations of Smac mimetics such as LBW242 or LCL161 in combination with chemotherapeutic agents increase cancer cell death. Here we show that the protein kinase C (PKC) activator TPA together with th

BACKGROUND: Extended-spectrum cephalosporin-resistant Enterobacteriaceae (ESCRE) are an increasing healthcare problem in both human and veterinary medicine. The spread of ESCRE is complex with multiple reservoirs and different transmission routes. The aim of this study was to investigate if ESCRE carriage in dogs is more prevalent in households with a known human carrier, compared to households wh

INTRODUCTION: Chronic peripheral neuropathic pain (CPNP) is a condition due to peripheral nervous system diseases or injury, but its prevalence is unknown in Italian primary care.AIM: The aim of this study is to assess the prevalence of CPNP in a rural primary care area in Northern Italy.MATERIALS AND METHODS: A multicenter audit study was carried out in a rural area in Northern Italy with 113 par