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En majoritet av alla funktioner i en organism eller enskild cell är helt och hållet beroende av proteiner, som i sin tur produceras enligt de gener som finns i cellernas DNA - proteiner är produkten av så kallat genuttryck. Alla gener kan dock omöjligt uttryckas samtidigt: att kunna reglera genuttrycket är helt nödvändigt för att vi ska kunna reagera och anpassa oss efter om- givningen, växa, utveThe ligand-binding domain (LBD) of PPARγ was studied in complex with the full agonist rosiglitazone in double- and triple-resonance NMR spectrom- etry experiments. The long-term aim was to better understand the structure and dynamics of the complex, and therefore how the transcription factor func- tions in vivo. The protein LBD was expressed in E. coli and complexed with rosiglitazone, and backbon

This thesis investigates the effects of the implementation of the USMCA and the COVID-19 pandemic on Canadian trade patterns at both the international level with the United States and the domestic level between provinces. Using a panel gravity model and bilateral trade data from 2016 to 2023, the study analyses how each of these developments influenced intra-Canadian and cross border trade flows.

Médecins Sans Frontières (MSF) does currently not have dedicated decision-making support for their in-country inventory allocation and is exploring how such decision support framework could be designed to enhance their supply chain operations. The purpose of this thesis is thus to develop a structured framework for country-level inventory allocation decision-making at MSF.To fulfil the purpose t

The accurate diagnosis of malaria is crucial for ensuring an effective treatment and combating the developing drug resistance of the parasite. The standard diagnostic method, consisting of light microscopy in combination with Giemsa-staining, requires manual examination through a trained clinician. This is time-consuming and prone to human error. While emerging diagnostic innovations can overcome

The growing demand for corporate transparency and sustainability has intensified the need for effective sustainability reporting, especially in industries like fashion, which face significant environmental and social challenges. This study examines how Patagonia, a leader in sustainable fashion, applies the Double Materiality (DM) framework in its social media communications, focusing on Instagram

The aim of this study is to identify what the relationship between ESG scores and capital structure is, and whether it differs depending on the selected capital structure measure. Building on previous literature on sustainability strategies and capital structure, this paper revises the current state of the interconnectivity between ESG and financing decisions. By employing a quantitative study wit

In this thesis, we apply Bayesian Optimization to estimate the parameters of the LPJ-GUESS dynamic vegetation model with a focus on Methane (CH4) emissions in the Siikaneva wetland in Finland. Previous research has used other statistical methods, such as Markov Chain Monte Carlo (MCMC), to estimate the LPJ-GUESS model parameters, achieving a root mean square error (RMSE) of 0.023. Our objective is

This thesis analyzes how moral brands discursively construct legitimacy and investigates the role of morality in legitimizing brand legitimacy claims and actions. By applying legitimacy theory, the study explores how Patagonia and TOMS Shoes legitimate their moral claims and actions based on discursive legitimation analysis (DLA). Findings showed the frequent and unexpected use of authorization, s

Drought is one of the most costly disasters worldwide. The complexity of nonlinear relationships between drought variables and drought severity during drought events poses significant challenges for accurate drought monitoring and prediction. Drought research in Morocco has been dominated by linear and conventional statistical methods, such as the pearson correlation. Although some earlier researc

The Light Dark Matter eXperiment (LDMX) is a planned missing momentum and energy experiment at SLAC, the purpose of which is to produce dark matter through production at an accelerator. A key theoretical process making this possible is called "dark bremsstrahlung," where an electron scattering off a nucleus produces a dark photon instead of a Standard Model photon. LDMX aims to detect da

A profound transformation toward sustainability is reshaping society. In every industry, organizations increasingly depend on Sustainable Development Goals (SDGs) and Environmental Social Governance (ESG) standards as crucial bench- marks to guide their operations. Making sustainability a core priority in corporate operations also involves integrating it into corporate communications. Internal com

The present study investigated the kinetic stability and activity of water-forming NAD(P)H oxidase (NOX) in a Liebig-type bubble column reactor, simulating industrial-scale conditions at laboratory scale. The study is divided into three parts, examining hydrodynamic parameters, NOX deactivation rate and protein concentration dynamics. The first part investigated and characterized the hydrodynamic

Title: Exploring the scope of optimizing the supply chain network - A case study on an Indian automotive company Author: Arvind Vikram Devendran Supervisor: Louise Bildsten - senior lecturer at the division of engineering logistics & program director of logistics and supply chain management Purpose: The purpose of this thesis is to investigate and propose an optimal solution for the current su

Keywords: Retro branding, message framing, message sequencing, nostalgia proneness, consumer innovativeness, willingness to try, Fast-moving consumer goods, new product brands, retail environment. Purpose: The study addresses the limited understanding of retro branding´s effectiveness in retail environments, particularly for new FMCG product brands without established heritage. It explores how

Character assassination (CA) is a strategic communication phenomenon with roots in ancient times, yet it remains underexplored in the literature on reputation management. While widely used in contemporary political environments, including those in Georgia, its intersection with the NGO sector has received relatively little scholarly attention. Positioned uniquely between the public and private sec

This thesis explores how sustainable entrepreneurs adapt their motivation and identity amid the emotional, moral, and strategic tensions of building purpose driven ventures. While previous research has examined motivation and identity separately, little attention has been paid to their interdependence, particularly in high uncertainty environments where values and viability collide. Integrating Se

This study explores the underlying motivations that lead middle-class consumers to eschew visible branding in favor of more inconspicuous forms of brands in their expression of self. Within the framework of contemporary Consumer Culture Theory, identity construction through symbolic consumption has been extensively examined. In this context, fashion, particularly the use of branded logos, has b

Geospatial data analysis plays a critical role in a wide range of applications, from urban planning and environmental monitoring to disaster response and infrastructure management. However, it remains technically demanding and largely inaccessible to non-experts due to the complexity of geospatial data structures, domain-specific tools, and the need for advanced programming knowledge. A particular

Drainage of peatlands causes changes in water table (WT), vegetation and decomposer community. As a consequence, decomposition patterns and carbon dynamics change, which is visible in altered Dissolved Organic Carbon (DOC) concentrations in ground and soil water. Additional changes in precipitation patterns towards more extreme drought and rain periods, as expected with climate change, cause furth

This thesis explores the influence of national culture on the management of mega-events, with particular focus on the Olympic Games and their role as a tool for nation branding. While various political, economic and environmental factors contribute to the planning and execution of such events, this study highlights the often-overlooked impact of cultural values on a nation’s image and reputation.