Alzheimer's Disease (AD) is the most prevalent form of dementia worldwide, yet the development of therapeutics has been hampered by the absence of suitable biomarkers to diagnose the disease in its early stages prior to the formation of amyloid plaques and the occurrence of irreversible neuronal damage. Since oligomeric A beta species have been implicated in the pathophysiology of AD, we reasoned

Interstitial photodynamic therapy (IPDT) provides a promising means to treat large cancerous tumors and solid organs inside the human body. The treatment outcome is dependent on the distributions of light, photosensitizer, and tissue oxygenation. We present a scheme for reconstructing the spatial distribution of a fluorescent photosensitizer. The reconstruction is based on measurements performed i

Intradialytic hypotension is the most common acute complication during conventional hemodialysis treatment. Prediction of such events is highly desirable in clinical routine for prevention. This paper presents a novel prediction method of acute symptomatic hypotension in which the photoplethysmographic signal is analyzed with respect to changes in amplitude, reflecting vasoconstriction, and cardia

Fetal cardiotocography is characterized by low specificity; therefore, in an attempt to ensure fetal well-being, fetal scalp blood sampling has been recommended by most obstetric societies in the case of a non-reassuring cardiotocography. The scientific agreement on the evidence for using fetal scalp blood sampling to decrease the rate of operative delivery for fetal distress is ambiguous. Based o

The MAX IV pro-injector will have one thermionic and one photocathode S-band RF gun, where the former will be used for ring injections. During ring injections, the bunches leaving the pre-injector have a structure that consists of ten 10 ns bunch trains, each containing three bunches. A chopper system consisting of two striplines and an adjustable aperture is used, where the desired bunch structur

Objective. There is an increased risk of gastrointestinal carcinoma and smoking-related diseases after partial gastrectomy for peptic ulcer disease. The purpose of this study was to evaluate long-term cancer incidence and mortality after parietal cell vagotomy (PCV), a surgical method with a low rate of side effects, but creating hypochlorhydria in the stomach mimicking long-term treatment with an

Edge aliasing continues to be one of the most prominent problems in real-time graphics, e.g., in games. We present a novel algorithm that uses shared memory between the GPU and the CPU so that these two units can work in concert to solve the edge aliasing problem rapidly. Our system renders the scene as usual on the GPU with one sample per pixel. At the same time, our novel edge aliasing algorithm

abstract is not available

In 1914 Professor Nathan Soderblom was elected archbishop of the Church of Sweden. His consecration took place in Uppsala Cathedral just months after the beginning of World War I. In 1925, he convened an ecumenical meeting in Stockholm that came to shape the ecumenical movement for decades to come. The peace question remained at the heart of his episcopate as long as it lasted. In this article, An

Arginine-rich cell penetrating peptides (ARCPPs) are known to quickly permeate cell membranes through a non-endocytotic pathway. Potential clinical applications of this facility have prompted enormous effort, both experimental and theoretical, to better understand how ARCPPs manage to overcome the prodigious thermodynamic cost of lipid bilayer permeation by these highly charged peptides. In this w

Abstract is not available

Timber structures and wooden element are in general affected by moisture and moisture variation in different ways. Their hygroscopic properties result in adsorption of water when wetted and in desorption when dried. Because the volume of wood is not constant but varies with the moisture content, uneven distribution of moisture will result in induced eigen-stresses because of internal restraint hyg

A review of the scientific development and progress in lichenology is reflected in 50 brief biographies of E. Acharius, V. Ahmadjian, T. Ahti, A. Aptroot, Y. Asahina, I. M. Brodo, D. H. Brown, B. Büdel, A. Crespo, W. L. Culberson, J. A. Elix, D. Fahselt, B. Fink, T. Friedl, D. J. Galloway, M. Galun, J. Hafellner, M. E. Hale, D. L. Hawksworth, A. Henssen, R. Honegger, P. W. James, P. M. Jørgensen,

Developing new and useful methods in asymmetric catalysis is of continuous importance. A current challenge is to address the imperatives of green chemistry, such that processes maximize resource-efficiency and minimize the generation of waste. To this end, this article discloses the potential of alpha-amino acids in the development of entropy-controlled and enantiodivergent Lewis acid catalysis. I