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Vocational outcome 6–15 years after a traumatic brain injury
Primary objective: To describe vocational outcome 6–15 years after a traumatic brain injury (TBI) among individuals who were productive by working or studying at the time of their TBI and determine associations with variables related to the time of injury and at follow-up. Methods and procedures: Thirty-four individuals with a mild TBI and 45 with a moderate-to-severe TBI were assessed on average
Turnover of matrix NADPH and NADH in plant mitochondria.
Primary proteolysis studied in a cast cheese made from microfiltered milk
Primary proteolysis was studied in a starter-free cheese model made from microfiltered (MF) milk (19.0% casein,
Evaluation of novel control elements by construction of eukaryotic expression vectors
A novel mammalian eukaryotic expression vector for the production of immunoglobulin heavy chain (IgH) genes has been designed. This expression vector contains the variable heavy chain (VH) promoter, the IgH intron enhancer (μE) and the IgH 3' enhancer (3'E). This construct, designated pTIF-1, was stably transfected into the myeloma cell line J558L. A fivefold increase in the expression level of a
Selection of binders from phage displayed antibody libraries using the BIAcore(TM) biosensor
In this report we show that phage displayed antibodies can be selected based on dissociation rate constants, using a BIAcore(TM) biosensor. To demonstrate the principle, two Fab phage stocks displaying antibodies specific for hen egg lysozyme or phenyloxazolone were mixed in a ratio of 1:10 and injected over the biosensor chip containing immobilized lysozyme. Antigen-specific bound phages were elu
Phospholamban inhibitors and a method for increasing coronary flow
A method for obtaining direct dilatation of the coronary arteries by administering a therapeutically effective amount of a phospholamban inhibitor is described. Compounds which are effective in relieving the inhibitory effects of phospholamban on cardiac sarcoplasmic reticulum Ca2+ -ATPase are also described.
Factors that Influence the Biochemical Methane Potential (BMP) Test : Steps towards the Standardisation of BMP Test
Anaerobic digestion (AD) has gained increasing attention nowadays as an approach for both waste treatment and renewable energy generation. Currently, many different types of materials can be used as feedstock for biogas production via AD process, but their biodegradability (based on methane yield, BDCH4) and potential to produce biogas might vary significantly, and these properties are key paramet
Preparations for retirement in Sweden: Migrant perspectives
Migrants as a group are recognised as being at risk of receiving low retirement pensions. Income over a lifetime is the principle for calculating pension rights. We have interviewed a group of migrants about their retirement preparations. Our results show that there are obstacles that obstruct migrants from entering the Swedish labour market, which will greatly influence future pension rights. The
Monitoring changes in membrane polarity, membrane integrity, and intracellular ion concentrations in Streptococcus pneumoniae using fluorescent dyes
Membrane depolarization and ion fluxes are events that have been studied extensively in biological systems due to their ability to profoundly impact cellular functions, including energetics and signal transductions. While both fluorescent and electrophysiological methods, including electrode usage and patch-clamping, have been well developed for measuring these events in eukaryotic cells, methodol
Biofilm formation enhances fomite survival of Streptococcus pneumoniae and Streptococcus pyogenes
Both Streptococcus pyogenes and Streptococcus pneumoniae are widely thought to rapidly die outside the human host, losing infectivity following desiccation in the environment. However, to date, all literature investigating the infectivity of desiccated streptococci has used broth-grown, planktonic populations. In this study, we examined the impact of biofilm formation on environmental survival of
Sensitization of Staphylococcus aureus to methicillin and other antibiotics in vitro and in vivo in the presence of HAMLET
HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a protein-lipid complex from human milk with both tumoricidal and bactericidal activities. HAMLET exerts a rather specific bactericidal activity against some respiratory pathogens, with highest activity against Streptococcus pneumoniae, but lacks activity against most other bacterial pathogens, including Staphylococci. Still, ion trans
Light chain shuffling of a cytomegalovirus glycoprotein B-specific antibody results in a modified epitope specificity
Neural tolerance of the non-ionic dimers iodixanol and iotrolan and the non-ionic monomer iopamidol during myelography in non-anaesthetised rabbits
PURPOSE: The neural tolerance of the recently introduced dimer iodixanol (320 g I/l) was compared with that of the dimer iotrolan (300 g I/l) and of the monomer iopamidol (300 g I/l), both used in clinical myelography.MATERIAL AND METHODS: Non-anaesthetised rabbits were injected into the cisterna magna with Ringer's solution (control) or contrast media (CM) at doses of 1.0 or 0.5 ml/kg b.w. The be
Relaxation dynamics of SF6 studied by energy resolved electron ion coincidence technique
The mass spectra from the SF6 molecule acquired by energy-resolved electron ion coincidence (EREICO) technique using (1t1g + [5t1u,1t2u]), (3eg + 1t2g), 4t1u, and 5a1g electrons after both valence and S 2p−1 6a1g core excitation reveal a strong selectivity in the dissociation from these states. From the comparison of the obtained spectra, the influence of the core-excited state in the relaxation p
Does endogenous glycosylation prevent the use of mouse monoclonal antibodies as cancer therapeutics?
Monoclonal antibodies have many potential therapeutic benefits. However, when applied to humans, mouse monoclonal antibodies have several disadvantages. Here Carl Borrebaeck and colleagues describe a strategy to overcome the anti-Gal activity, thought to be one of the reasons why mouse mAbs have a limited half-life.
Experimental investigation of the stability limits of premixed syngas-air flames at two moderate swirl numbers
This article presents an investigation of the swirl number effects on the stability limits of various syngas compositions in an atmospheric premixed variable-swirl burner. Lean blowout (LBO) and flashback (FB) experiments were performed using fuel mixtures containing varying amounts of H2, CO and CH4 at two swirl numbers. Reducing the swirl number from 0.66 to 0.53, reduced the flashback propensit
A new generation of algorithms for computerized threshold perimetry, SITA
PURPOSE: The purpose of this work was to develop a new family of test algorithms for computerized static threshold perimetry which significantly reduces test time without any reduction of data quality.METHODS: A comprehensive visual field model constructed from available knowledge of normal and glaucomatous visual fields is continuously updated during testing. The model produces threshold estimate
T1-mapping and OE-MRI of patients treated with radiotherapy for breast cancer
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