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Objectives: Positive resection margins after breast-conserving surgery (BCS) most often demands a repeat surgery. To preoperatively identify patients at risk of positive margins, a multivariable model has been developed that predicts positive margins after BCS with a high accuracy. This study aimed to externally validate this prediction model to explore its generalizability and assess if additiona

Background: The Prostatype score (P-score) is a prognostic biomarker that integrates a three-gene (IGFBP3, F3, and VGLL3) signature derived from prostate biopsy samples, with key clinical parameters, including prostate-specific antigen (PSA) levels, Gleason grade, and tumor stage at diagnosis. The test has demonstrated superior predictive accuracy for prostate cancer outcomes compared with traditi

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of dexmedetomidine compared with opioids, non-opioids and placebo in providing sedation and analgesia for procedural pain in newborn infants.

Background: Von Willebrand disease (VWD) is an inherited bleeding disorder caused by deficient or dysfunctional von Willebrand factor (VWF). VWF replacement therapy is indicated in VWD management. Methods: This systematic review was conducted to evaluate all available evidence of the efficacy, safety, dosing and consumption of pasteurized plasma-derived human coagulation FVIII/human VWF (pdVWF/FVI

Extracellular vesicles (EVs) carry biological information from their parent cell to other cells in the body. To intercept and decipher this information necessitates the isolation of EVs from complex backgrounds such as blood or spinal fluid. Acoustic trapping has been previously demonstrated as a promising technique for EV isolation from cell media, blood plasma and urine. The acoustic fields stru

Group A Streptococcus (GAS; Streptococcus pyogenes) is an important bacterial pathogen causing over 700 million superficial infections and around 500.000 deaths due to invasive disease or severe post-infection sequelae yearly. In spite of this major impact on society, there is currently no vaccine available against this bacterium. GAS strains can be separated into >250 distinct emm (M)-types, and

This study explored whether authoritarian or authoritative parenting practices for adolescents would mediate the association between involvement in bullying and severe forms of violent behaviors. Cross-sectional data were collected from a matched sample of 120 African-American adolescents, ages 13–24 (Mage = 14.79 years, 27.5% boys), and their caregivers. The survey included self-report measures o

Two synchrotron-based studies on 4H-pyran-4-thione, photoelectron spectroscopy and vacuum ultraviolet (VUV) absorption spectra were performed. A highly resolved structure was observed in the photoelectron spectrum (PES), in contrast to an earlier PES study, where little structure was observed. The sequence of ionic states was determined using configuration interaction and coupled cluster methods.

Background: COPD management is guided by the respiratory symptom burden, assessed using the modified Medical Research Council (mMRC) scale, the COPD Assessment Test (CAT), or both. Research Question: What are the abilities of mMRC and CAT to detect abnormally high exertional breathlessness on incremental cardiopulmonary cycle exercise testing (CPET) in people with COPD? Study Design and Methods: A

Recent advances in 3D printing have enabled fabrication of architected functional ceramics with tunable functionalities at reduced weight and cost. An essential cornerstone of materials design is to determine structure–property relations. For polycrystalline ferroelectrics, such relationships can be complex due to several microscopic mechanisms, such as lattice strains and/or domain switching, whi

Lignin has emerged as a sustainable alternative to fossil-based polymers in advanced materials such as photonics. However, current methods for preparing photonic lignin materials are limited by non-benign organic solvents and low production yields. In this work, we present a highly efficient process that enables the production of photonic glasses with yields ranging from 48% to 72%, depending on t

Cryptic genetic differentiation is being increasingly documented in birds and other organisms using genome-wide variation. A recent example of cryptic genetic differentiation in a widespread species with conserved morphology is the northern house wren Troglodytes aedon. We found that, despite extremely similar morphology and no documented vocal differences, the two subspecies of the northern house

This study investigates the requirements for estimating CO2 emissions at the country scale using observational data from the Integrated Carbon Observation System (ICOS) atmosphere network, taking Italy as a case study. In particular, we explore the potential expansion of Italy’s current atmospheric ICOS network by identifying additional existing and future stations that would most effectively impr

A continental-type glacial flood termed the Suwałki megafloods took place in NE Poland during the last glaciation and significantly transformed the proglacial area. This study aims, for the first time, to establish the chronology of this flood. Twenty-two sediment samples from two meltwater spillways were dated by optically stimulated luminescence. Sixteen ages from the flood megadunes are between

The Oriental fruit moth Grapholita molesta is distributed throughout temperate regions and considered to be a pest in peach production and other high-value fruit crops in the rose family. Insecticide treatment has led to resistance development, but the use of sex pheromones in pest management has shown great promise. We investigated the pheromone biosynthesis pathway in G. molesta with the aim of

The present paper discusses the effects of social identity and self-determination theory and highlights their relevance for welfare conditionality with respect to individual behaviour and well-being. While welfare conditionality may provide economic incentives for certain desired behaviours, e.g., active job search, it is argued that their impact on the claimants’ social self-construal and identit

Traumatic brain injury is widely viewed as a risk factor for dementia, but the biological mechanisms underlying this association are still unclear. In previous studies, traumatic brain injury has been associated with the hallmark pathologies of Alzheimer's disease, i.e. amyloid-β plaques and neurofibrillary tangles comprised of hyperphosphorylated tau. Depending on the type and location of trauma,

Om alla människor hade möjlighet att välja medborgarskap, som man väljer bostad eller annan konsumtion, skulle vi implicit observera deras preferensergenom dessa beslut. Medborgarskap kan betraktas som privat men ej överlåtbar egendom. Om medborgarskapet blev överlåtbart och vi kunde handla meddem och hade en etablerad handelsplats – likt en aktiebörs – skulle vi kunna observera marknadspriser på

Generalist parasites experience selective pressures from the various host species they infect. However, it is unclear if parasite transmission among host species precludes the establishment of host-specific adaptations and population genetic structure. We assessed the population genetic structure of the vector-transmitted avian haemosporidian parasite Haemoproteus majoris (lineage WW2; n = 34 infe